History and Principles of Dynamic Combinatorial Chemistry

Simultaneous Disulfide and Boronic Acid Ester Exchange in Dynamic Combinatorial Libraries

“…The dynamic combinatorial approach relies on the availability of an arsenal of reversible chemical reactions [ 3 , 4 ]. In most studies exploring dynamic combinatorial libraries, a single type of reversible chemical reaction is used.…”

Dynamic Multivalency for Carbohydrate–Protein Recognition through Dynamic Combinatorial Libraries Based on FeII–Bipyridine Complexes

“…Dynamic combinatorial Libraries (DCLs) have recently been employed to enhance and optimize binding affinities of carbohydrates to the surface of sugar‐binding proteins (lectins),1 as their thermodynamic equilibrium is biased towards the best‐matching arrangement by simply adding the respective target 1a. 2 It is widely accepted that multivalent presentation of binding sugar units is the method of choice for enhancing binding affinities towards protein surfaces,3 the development of anti‐pathogenic agents employing this concept is of high contemporary interest 4. In biological systems, polymeric sugar‐based structures owe their high affinities largely to the so‐called “cluster glycoside effect” 5.…”

Protein‐Templated Fragment Ligations—From Molecular Recognition to Drug Discovery

“…Ramström and co‐workers have described a reversible templated Henry‐aldol addition of nitroalkanes to aldehydes, in which the formed, best‐bound secondary alcohol was preferably acylated by the lipase as the protein target in the assay . Although no further reports on templated aldol reactions have yet been published, this reaction type should be highly suitable for fragment ligation chemistry considering the detailed literature on aldol reactions in water and under mild reaction conditions . Likewise, additions of cyanide anions and isocyanides have been reported in water, which suggests that Passerini and Ugi reactions might be highly suitable for protein‐templated reactions.…”