History of Cryosurgery

Korpan, Nikolai N.

doi:10.1007/978-3-7091-6207-1_2

Cited by 4 publications

(13 citation statements)

References 36 publications

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“…Probably the most important artifact to simulate for virtual cryosurgery training is the shadowing effect due to freezing [2,4]. In practice, this artifact is used to track the progression of the freezing front, from the cryoprobes towards the US transducer.…”

Section: Resultsmentioning

confidence: 99%

“…Placement of minimally invasive cryoprobes relies on the imaging artifacts created by the cryoprobes, which have the shape of long hypodermic needles with sharp-pointed tips. Monitoring the frozen region formation also relies on ultrasound (US) imaging artifacts, where the tissue becomes opaque upon freezing [4]. In order to advance surgical training [5], a virtual cryosurgery setup can be envisioned, where a trainee can practice cryoprobe placement under simulated TRUS imaging.…”

Section: Introductionmentioning

confidence: 99%

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GPU-Based Simulation of Ultrasound Imaging Artifacts for Cryosurgery Training

Keelan

Shimada

Rabin

2016

Technol Cancer Res Treat

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This study presents an efficient computational technique for the simulation of ultrasound imaging artifacts associated with cryosurgery based on nonlinear ray-tracing. This study is part of an ongoing effort to develop computerized training tools for cryosurgery, with prostate cryosurgery as a development model. The capability of performing virtual cryosurgical procedures on a variety of test cases is essential for effective surgical training. Simulated ultrasound imaging artifacts include reverberation and reflection of the cryoprobes in the unfrozen tissue, reflections caused by the freezing front, shadowing caused by the frozen region, and tissue-property changes in repeated freeze-thaw cycles procedures. The simulated artifacts appear to preserve the key features observed in a clinical setting. This study displays an example of how training may benefit from toggling between the undisturbed ultrasound image, the simulated temperature field, the simulated imaging artifacts, and an augmented hybrid presentation of the temperature field superimposed on the ultrasound image. The proposed method is demonstrated on a graphic processing unit (GPU) at 100 fps, on a mid-range personal workstation, at two orders of magnitude faster than a typical cryoprocedure. This performance is based on computation with C++ accelerated massive parallelism (AMP) and its interoperability with the DirectX rendering API.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

GPU-Based Simulation of Ultrasound Imaging Artifacts for Cryosurgery Training

Keelan

Shimada

Rabin

2016

Technol Cancer Res Treat

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“…The application of cryogenic techniques for resection of parenchymal organs [3,5] and in situ ablation of tumors using subzero temperatures for surface malignancies [4] have been described. An inadequately addressed aspect of cryosurgery is the mechanism by which damage is affected during the freezing process.…”

Section: Discussionmentioning

confidence: 99%

“…The advances in cryosurgical technology have also aroused interest in the use of cryosurgery to treat liver malignancies [1][2][3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Cryosurgery: Early Ultrastructural Changes in Liver Tissue In Vivo

Korpan

2009

Journal of Surgical Research

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Cryo-Assisted Resection En Bloc, and Cryoablation In Situ, of Primary Breast Cancer Coupled With Intraoperative Ultrasound-Guided Tracer Injection: A Preliminary Clinical Study

Korpan

Schwarzinger

et al. 2018

Technol Cancer Res Treat

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The aim of the study was to perform cryosurgery on a primary breast tumor, coupled with simultaneous peritumoral and intratumoral tracer injection of a blue dye, to evaluate lymphatic mapping. We explored the ability of our strategy to prevent tumor cells, but not that of injected tracers, to migrate to the lymphovascular drainage during conventional resection of frozen breast malignancies. Seventeen patients aged 51 (14) years (mean [standard deviation]), presenting primary breast cancer with stage I to IV, were randomly selected and treated in The Rudolfinerhaus Private Clinic in Vienna, Austria, and included in this preliminary clinical study. Under intraoperative ultrasound, 14 patients underwent curative cryo-assisted tumor resection en bloc, coupled with peritumoral tracer injection, which consisted of complete tumor freezing and concomitant peritumor injection with a blue dye, before resection and sentinel lymph node dissection (group A). Group B consists of 3 patients previously refused any standard therapy and had palliative tumor cryoablation in situ combined with intratumoral tracer injection. The intraoperative ultrasound facilitated needle positioning and dye injection timing. In group A, the frozen site extruded the dye that was distributed through the unfrozen tumor, the breast tissue, and the resection cavity for 12 patients. One to 4 lymph nodes were stained for 10 of 14 patients. The resection margin was evaluable. Our intraoperative ultrasound-guided performance revealed the injection and migration of a blue dye during the frozen resection en bloc and cryoablation in situ of primary breast tumors. Sentinel lymph node mapping, pathological determination of the tumor, and resection margins were achievable. The study paves the way for intraoperative cryo-assisted therapeutic strategies for breast cancer.

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History of Cryosurgery

Cited by 4 publications

References 36 publications

GPU-Based Simulation of Ultrasound Imaging Artifacts for Cryosurgery Training

GPU-Based Simulation of Ultrasound Imaging Artifacts for Cryosurgery Training

Cryosurgery: Early Ultrastructural Changes in Liver Tissue In Vivo

Cryo-Assisted Resection En Bloc, and Cryoablation In Situ, of Primary Breast Cancer Coupled With Intraoperative Ultrasound-Guided Tracer Injection: A Preliminary Clinical Study

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