History of Dermabrasion

Lawrence, Naomi; Yarborough, John M.; Alt, Thomas H.

doi:10.1046/j.1524-4725.2000.00402.x

Cited by 35 publications

(14 citation statements)

References 85 publications

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“…Biopsies of dermabraded and untreated skin were analyzed after the treated sites were allowed to heal for three months. Consistent with previous reports, dermabraded skin demonstrated increased synthesis of collagen [39-40; Supplemental Fig. 2] and a restoration of the dermal collagen structure similar to that found in young adults (Fig.…”

Section: Resultssupporting

confidence: 91%

“…Cosmetic dermal rejuvenation techniques have been widely used to stimulate the production of new collagen synthesis by inducing a ‘wounding response' in the skin [39-40]. As such, it was of interest to determine if these dermal rejuvenation techniques restored a more youthful phenotype and biology to geriatric skin, and specifically to determine if these techniques could restore the appropriate DNA-damage response found in young skin to UVB-irradiated geriatric skin.…”

Section: Resultsmentioning

confidence: 99%

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Reversing the aging stromal phenotype prevents carcinoma initiation

Lewis

Travers

Machado

et al. 2011

Aging

101

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The accumulation of senescent stromal cells in aging tissue changes the local microenvironment from normal to a state similar to chronic inflammation. This inflammatory microenvironment can stimulate the proliferation of epithelial cells containing DNA mutations which can ultimately lead to cancer. Using geriatric skin as a model, we demonstrated that senescent fibroblasts also alter how epithelial keratinocytes respond to genotoxic stress, due to the silencing of IGF-1 expression in geriatric fibroblasts. These data indicate that in addition to promoting epithelial tumor growth, senescent fibroblasts also can promote carcinogenic initiation. We hypothesized that commonly used therapeutic stromal wounding therapies can reduce the percentage of senescent fibroblasts and consequently prevent the formation of keratinocytes proliferating with DNA mutations following acute genotoxic (UVB) stress. Sun-protected skin on the lower back of geriatric human volunteers was wounded by dermabrasion and the skin was allowed to heal for three months. In geriatric skin, we found that dermabrasion wounding decreases the proportion of senescent fibroblasts found in geriatric dermis, increases the expression of IGF-1, and restores the appropriate UVB response to epidermal keratinocytes in geriatric skin. Therefore, dermal rejuvenation therapies may play a significant role in preventing the initiation of skin cancer in geriatric patients.

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Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Reversing the aging stromal phenotype prevents carcinoma initiation

Lewis

Travers

Machado

et al. 2011

Aging

101

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“…1 They recognized that producing partial-thickness abrasion improved the appearance of skin. Modern era dermabrasion was pioneered in 1905 by Kromayer.…”

Section: Introductionmentioning

confidence: 99%

29 Dermabrasion and Microdermabrasion: Rationale, Application, Safety Concerns, and Complications

Truswell¹

2016

Lasers and Light, Peels and Abrasions

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The history of dermabrasion dates back to 1550 BC when Egyptian physicians used alabaster and pumice to smooth scars and skin blemishes. 1 They recognized that producing partial-thickness abrasion improved the appearance of skin. Modern era dermabrasion was pioneered in 1905 by Kromayer. 2 In 1953, Kurtin refined the dermabrasion technique with modified, powered dental equipment using topical refrigerants and a wire brush. 3 There are three main modalities for skin resurfacing: chemical peel, laser resurfacing, and mechanical dermabrasion. The contemporary trend favors the use of the laser-resurfacing technique. Many clinicians feel that laser resurfacing allows for more controlled thermal injury and more consistent outcomes with less operator-dependent variability. Whereas the newest laser technology has significantly reduced risk associated with thermal injury to surrounding tissues, in experienced hands, dermabrasion provides great manual control to the depth of destruction without spreading the thermal injury to deeper layers of the skin. MechanismThere are five layers of epidermis: stratum corneum at the surface followed by lucidum, granulosum, spinosum, and basalis. The thickness of epidermis varies depending on age of the patient and location of the skin. Average thickness of facial skin epidermis is approximately 100 µm thick, although at the eyelids it may be only 50 µm thick. 4 Four major cell types are found in the epidermis, including keratinocytes (80%), melanocytes, Langerhans cells, and Merkel cells. In the basalis layer, melanocytes generate skin pigmentation through the actions of the tyrosinase enzyme. 5 The rete ridges are projections of the epidermis into the dermis that help increase the surface area of contact between the two interfaces. In both processes of aging and scar formation, histological changes observed include loss of elastic fiber, atrophy of collagen bundles, and flattening of rete ridges. 6,7 The dermis consists of papillary and reticular layers. The papillary layer is located below the basement membrane and contains mostly loose collagen and fibrocytes. The reticular layer contains thicker, compact collagen, and the adnexal structures of the skin such as sweat glands, hair follicles, and sebaceous glands. On the hairless part of the face, such as the nose, the sebaceous unit is the predominant adnexal structure. Within the adnexal structures are the epithelial stem cells capable of differentiation and re-epithelialization. 8 The goal of dermabrasion is to mechanically remove the epidermis while preserving the adnexal structures (▶ Fig. 29.1). This is accomplished with the use of a motorized handpiece and a rotating tip composed of either a wire brush or diamond particle-coated fraise (▶ Fig. 29.2). The depth of injury is controlled by the surgeon carefully abrading the skin to the desired layer (▶ Fig. 29.2). Controlled injury to the epidermis and papillary dermis heals without scarring; however, if the injury penetrates deep into the reticular dermis where the adnexal struct...

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“…The history of dermabrasion dates back to 16th century Egypt, but its introduction in the plastic surgery literature occurred in 1947, when Iverson described a technique of planing skin to the dermis with sandpaper in order to correct traumatic tattoos . The technique was further refined in dermatology by Kurtin in 1953, who pioneered the use of the mechanized wire brush, specifically for acne scars .…”

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confidence: 99%