History of human papillomavirus, warts and cancer: What do we know today?

Onon, Toli S.

doi:10.1016/j.bpobgyn.2011.05.001

Cited by 17 publications

(16 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HPV is one of the most common STDs worldwide (8). Nearly all sexually active individuals may be infected by HPV at some point during their lifetime (9).…”

Section: Introductionmentioning

confidence: 99%

Association between human papillomavirus and prostate cancer: A meta-analysis

et al. 2017

View full text Add to dashboard Cite

Abstract. Observational studies have suggested an association between human papillomavirus (HPV) infection and the risk of prostate cancer (PCa). However, the association between HPV infection and the risk of PCa remains unclear. The aim of the present meta-analysis study was to investigate whether HPV serves a role in increasing the risk of PCa. Relevant previous studies up to May 2015 were searched in PubMed, Web of Science, Cochrane library, Chinese National Knowledge Infrastructure, China Wan Fang database and China Biomedical Literature Database. A random-effects model or fixed-effects model was employed to determine odds ratios (ORs) with 95% confidence intervals (CIs), when appropriate. Heterogeneity was evaluated using Q and I 2 statistical analysis. A total of 24 case-control studies involving 971 patients and 1,085 controls were investigated to estimate the association between HPV infection and PCa risk. The pooled estimate for OR was 2.27 (95% CI, 1.40-3.69). Stratified pooled analyses were subsequently performed according to the HPV detection methods, geographical regions, publication years and types of tissue. Sensitivity analysis based on various exclusion criteria maintained the significance with respect to PCa individually. Little evidence of publication bias was observed. The meta-analysis suggested that HPV infection is associated with increasing risk of PCa, which indicated a potential pathogenetic link between HPV and PCa.

show abstract

“…HPV is one of the most common STDs worldwide (8). Nearly all sexually active individuals may be infected by HPV at some point during their lifetime (9).…”

Section: Introductionmentioning

confidence: 99%

Association between human papillomavirus and prostate cancer: A meta-analysis

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Infection with HPV is also associated with genital warts and other types of anogenital neoplasia, including penile, anal and oropharyngeal tumours. [11] Although genital warts are not life threatening, they are common and cause considerable psychosocial and sexual morbidity. [9] Genital warts in both men and women are readily transmitted, have a high recurrence rate after treatment, and cause local pain and discomfort.…”

Section: Discussionmentioning

confidence: 99%

“…For biopsy samples in excess of the recommended size, the Qiagen protocol was used only to provide a first-step digestion lysate of tissue. Anogenital wart biopsy DNA was subjected to HPV typing employing the Roche Linear Array HPV genotyping kit (testing for HPV types 11,16,18 The HPV target DNA for amplification was a 450-bp fragment of the L1 region. To confirm sample quality and the DNA extraction process, a second target was a 268-bp fragment of the human β-globin gene.…”

Section: Hpv Analysismentioning

confidence: 99%

Human papillomavirus genotypes and clinical management of genital warts in women attending a colposcopy clinic in Cape Town, South Africa

et al. 2015

View full text Add to dashboard Cite

Background. Genital human papillomavirus (HPV) infection is the most common sexually transmitted viral disease in the world. HPV infection of the genital epithelium is associated with genital warts and malignancies of the lower genital tract. Objectives. To describe the distribution, phenotypic appearance and HPV type associated with genital warts in women.Methods. This was a prospective observational study of all women with genital warts who attended the Colposcopy Clinic, Groote Schuur Hospital, Cape Town, South Africa, during 2010 and fulfilled the inclusion and exclusion criteria. One hundred and thirteen women were tested for HPV using the Roche Linear Array HPV genotyping kit to determine the HPV genotypes causing genital warts. Results. The median age of the women was 27 years (range 15 -53); 90 (79.6%) were HIV-positive, and two-thirds were on antiretroviral treatment. Treatment involved ablation with topical agents, cauterisation or carbon dioxide laser. At 3 months' follow-up after treatment, 56.6% of the women, the majority of whom were HIV-positive, had recurrent/persistent disease. In both HIV-positive and HIV-negative women, HPV was detected in over 90% of cases. However, over half the HIV-positive women as opposed to 2/18 of the HIV-negative women were infected with multiple HPV genotypes. The commonest HPV genotypes in HIV-positive and HIV-negative women were types 11, 6, 89, 61, 55 and 62 and types 11 and 6, respectively. Conclusions. The majority of the patients were HIV-positive and had multiple HPV infections. While this did not alter the phenotypic appearance of the warts, recurrence/persistence after treatment was more common.

show abstract

“…One of the earliest manifestations of HPV infection was observed during an autopsy performed in 1974 on the embalmed body of an ancient Egyptian worker from 12 th century BC who had a wart on the sole of his foot (Onon, 2010, as cited in McCaffery, 1974. The Ancient Greeks and Romans had already recognized that genital warts could be sexually transmitted (Onon, 2010, as cited in Claude Moore Health Sciences Library, 2011); however, the viral origin of warts was only confirmed in the 19 th century (Onon, 2010, as cited in Ciuffo, 1907.…”

Section: Historical Aspectsmentioning

confidence: 99%

“…The Ancient Greeks and Romans had already recognized that genital warts could be sexually transmitted (Onon, 2010, as cited in Claude Moore Health Sciences Library, 2011); however, the viral origin of warts was only confirmed in the 19 th century (Onon, 2010, as cited in Ciuffo, 1907. By the early 1970s, the herpes simplex virus type 2 was thought to be the sexually transmitted etiologic factor that was responsible for cervical cancer (Onon, 2010, as cited in Klein, 1973. However, Harald Zur Hausen, a young German professor of virology, was not convinced of this hypothesis, and in 1976, he postulated that papilloma viruses play a role in cancer of the cervix.…”

Section: Historical Aspectsmentioning

confidence: 99%