History of Mohs Surgery

Trost, Leonid Benjamin; Bailin, Philip L.

doi:10.1016/j.det.2011.01.010

Cited by 38 publications

(24 citation statements)

References 19 publications

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“…Its mechanism of action is degeneration of protein by astringent of ionized zinc that is produced by chemical reaction of zinc chloride and the exudate from skin wound. The paste is costeffective and non-toxic to medical practitioners (Mohs & Guyer 1941;Mohs 1989;Trost & Bailin 2011). It is experimentally associated with a decreased risk of metastasis (Mohs & Guyer 1941;Kalish et al 1998;Brook 2010).…”

Section: Introductionmentioning

confidence: 99%

“…Zinc chloride fixative paste (called Mohs paste) was developed by Frederic E. Mohs in the 1930s, and used for fixed-tissue micrographic surgery in accessible skin tumors (Phelan 1968;Mohs 1970Mohs ,1971Mohs ,1989Brook 2010;Trost & Bailin 2011). Its mechanism of action is degeneration of protein by astringent of ionized zinc that is produced by chemical reaction of zinc chloride and the exudate from skin wound.…”

Section: Introductionmentioning

confidence: 99%

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The palliative efficacy of modified Mohs paste for controlling canine and feline malignant skin wounds

Fukuyama

Kawarai

Tezuka³

et al. 2016

Veterinary Quarterly

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In veterinary medicine, the management of malignant skin wounds is highly challenging. We conducted a study on seven case animals (four dogs and three cats) which presented with malignant skin wounds. All seven animals had signs and symptoms which were controlled following treatment with a modified Mohs paste. Upon obtaining informed consent from their owners, the animals requiring management of malignant wounds were enrolled in this study. The modified Mohs paste was prepared by mixing zinc chloride, zinc oxide starch powder, glycerin, and distilled water. The modified Mohs paste was topically applied to and left to remain on the malignant wounds for one hour, under controlled conditions. Once the paste was removed, the wounds were irrigated with a solution of sterile saline. At the first examination, the wounds of each animal were observed for signs of exudate, malodor, and bleeding. In every case, visible improvement was observed immediately after the modified Mohs paste treatment. Specifically, the size of the malignant wounds, and the number of times the dressing gauze required changing, significantly decreased (p < 0.05 and p < 0.01, respectively). The open malignant skin wounds caused by mammary gland tumors disappeared in two cases. The Mohs paste has been shown to be a viable option for the palliative treatment in canine and feline malignant skin wound management.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The palliative efficacy of modified Mohs paste for controlling canine and feline malignant skin wounds

Fukuyama

Kawarai

Tezuka³

et al. 2016

Veterinary Quarterly

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show abstract

“…Mohs' paste comprises a mixture of zinc chloride, distilled water, zinc powder, and glycerin. Zinc chloride has multiple beneficial features: it penetrates into the tissue well, allows precise control of fixation depth, does not interfere with subsequent second-intention healing, is not systemically toxic, is safe to handle, and lacks odor [6].…”

Section: Discussionmentioning

confidence: 99%

Successful pre-operative local control of skin exposure by sarcoma using combination of systemic chemotherapy and Mohs’ chemosurgery

et al. 2020

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Background: Sarcomas sometimes invade the skin and become exposed, producing malignant wounds characterized by bleeding, exudate, odor, and infection. Malignant cutaneous sarcomas are generally incurable and ultimately impair patients' quality of life. Mohs' chemosurgery is a previously published technique for chemical fixation of a cutaneous tumor and subsequent excision. Case presentation: We present the case of a 44-year-old man with an undifferentiated pleomorphic sarcoma arising in the right chest wall and rupturing through the skin. The tumor manifested as a malignant wound with ulceration, bleeding, exudate, and a strong odor. Treatment with systemic chemotherapy and Mohs' chemosurgery was initiated. After repeated courses, the tumor demonstrated significant shrinkage. We were then able to perform wide resection and reconstruction with a rectus abdominis musculocutaneous flap. Pathologic examination of the resected specimen confirmed negative margins. Conclusions: Mohs' chemosurgery with concurrent systemic chemotherapy is an effective and reliable treatment option for achieving pre-operative local control of sarcomas that rupture through the skin.

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“…Thus, it often took several days of surgery and multiple stages to achieve clear margins for large skin cancers. 16,20 In addition, Dr. Mohs introduced the technique of horizontal sectioning and color-coding of specimens, which allowed 100% margin examination while maintaining proper tissue orientation. 19,21 In comparison, traditional vertical sectioning evaluates only approximately 0.01% of the entire tissue margins.…”

mentioning

confidence: 99%

“…He found that second-intention healing produced cosmetically acceptable results and sometimes even better outcomes than primary closure in concave areas. 16,18 In 1941, Dr. Mohs presented his findings in the Archives of Surgery and named this technique chemosurgery. 22 This study included 440 patients whom he treated successfully using this technique for more than 4 years.…”

mentioning

confidence: 99%

Mohs Micrographic Surgery: Development, Technique, and Applications in Cutaneous Malignancies

Chen

Srivastava

Nijhawan

2018

Seminars in Plastic Surgery

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Mohs micrographic surgery (MMS) is a specialized technique for treating skin malignancies that offers the highest cure rate by allowing histological evaluation of the entire peripheral and deep margins. MMS also maximally preserves as much uninvolved, normal adjacent tissue as possible, allowing for the best cosmetic and functional outcomes. When used for appropriate indications, this technique is also more cost-effective than other treatment modalities. In this article, the authors will discuss the development of MMS, the steps involved in this procedure, and the indications for this technique. They will also review the use of MMS for basal cell carcinoma, squamous cell carcinoma, melanoma in situ, and some less common skin malignancies.

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History of Mohs Surgery

Cited by 38 publications

References 19 publications

The palliative efficacy of modified Mohs paste for controlling canine and feline malignant skin wounds

The palliative efficacy of modified Mohs paste for controlling canine and feline malignant skin wounds

Successful pre-operative local control of skin exposure by sarcoma using combination of systemic chemotherapy and Mohs’ chemosurgery

Mohs Micrographic Surgery: Development, Technique, and Applications in Cutaneous Malignancies

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