History of tonsillectomy and appendectomy in Hodgkin's disease

Gledović, Z; Radovanović, Zoran

doi:10.1007/bf00218670

Cited by 14 publications

(11 citation statements)

References 27 publications

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“…Contradictory results exist in the literature. Some studies have observed a significant decrease in cellular and humoral immunity, particularly the secretion of immunoglobulin A, and an increase in the incidence of immunomodulatory diseases , but opposing outcomes have also been reported . Bitar et al .…”

Section: Discussionmentioning

confidence: 99%

Tonsillectomy and inflammatory bowel disease: a meta‐analysis

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Tonsillectomy and inflammatory bowel disease: a meta‐analysis

et al. 2016

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“…A prevailing hypothesis for an association between tonsillectomy and Hodgkin's lymphoma (HL) has been that removal of the “lymphoid tissue barrier” would predispose to the development of HL 1. However, so far, epidemiological studies have been conflicting,1, 2 as case–control studies have reported either an increased risk of HL following tonsillectomy1, 3–6 or no association 2, 7–18. One nation‐wide cohort study found a marginally increased risk for all age groups, but a 4‐fold increased HL risk was found for persons tonsillectomized before the age of 12 years 19.…”

mentioning

confidence: 99%

Tonsillitis, tonsillectomy and Hodgkin's lymphoma

Vestergaard

Westergaard

Wohlfahrt

et al. 2010

Intl Journal of Cancer

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It has been debated whether the reported increased risk of Hodgkin's lymphoma (HL) after tonsillectomy could be due to some underlying factor rather than the surgery itself. We studied whether not only tonsillectomy but also tonsillitis was associated with HL. This nationwide cohort study included all Danish residents during 1977–2001. Information on a diagnosis of tonsillitis, tonsillectomy, or HL was obtained from national registries. During 124 million person‐years we observed 2,988 HL patients of whom 58 were tonsillectomized (most with preceding tonsillitis) and 14 were diagnosed with only tonsillitis at more than 1 year before HL diagnosis. Tonsillectomy was associated with a significantly increased HL risk in persons under 15 years of age as follows: 1–4 years after tonsillectomy, relative risk (RR) = 3.9 [95% CI: 1.4–11; n = 4]; >5 years after tonsillectomy, RR = 3.5 [1.4–8.5; n = 5]. No young cases of HL occurred among persons diagnosed with only tonsillitis. In contrast, 1–4 years after a hospital diagnosis of tonsillitis without subsequent tonsillectomy we found an increased HL risk in persons aged 15 years or above as follows: 15–34 years of age at HL diagnosis, RR = 3.5 [1.6–7.7; n = 6]; 35+ years, RR = 5.9 [2.2–16; n = 4]. Age at tonsillitis or tonsillectomy did not modify HL risk within the 3 age strata. An increased HL risk was found both after tonsillectomy and after an isolated diagnosis of tonsillitis. These results suggest that tonsillitis is a risk factor for HL and not that, as previously reported, only the surgical removal of tonsils is a risk factor.

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“…Although some studies have linked tonsillectomy with increased risk for Hodgkin's disease (HD) (Vianna et al, 1971;Abramson et al, 1978;Kirchhoff et al, 1980), such findings were not reported in other studies (Johnson and Johnson, 1972;Newell et al, 1973;Gledovic and Radovanovic, 1991). Despite the apparent decline in immunologic function of the tonsils from childhood to adulthood (Brandtzaeg, 1987;Andersson et al, 1994), few studies have investigated the subsequent risk of HD associated with tonsillectomy according to the patient's age at surgery.…”

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confidence: 99%

Risk of Hodgkin's disease subsequent to tonsillectomy: A population-based cohort study in Sweden

et al. 1997

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Although some studies have linked excess of Hodgkin's disease (HD) to tonsillectomy, the findings have not been consistent. In particular, risk of HD by age at tonsillectomy has not been fully evaluated, despite the notable change in immunologic function of the tonsils between childhood and adulthood. To evaluate the risk of HD and other lymphomas, associated with tonsillectomy according to age at surgery, a population-based cohort study was conducted. Using nationwide Swedish hospitalization records, 55,169 patients undergoing tonsillectomy with/without adenoidectomy (T/A) were identified during the period 1964-1983. By linkage with the nationwide Total Population, Migration, Cancer and Causesof-Death registries, these patients were followed up for as long as 25 years. After exclusion of the first post-operative year, a total of 533 first primary-cancer cases was identified between 1965 and 1989. Small excess risk was observed for HD (20 cases, SIR ϭ 1.4, 95% CI 0.9-2.2). HD risk was more pronounced among patients tonsillectomized before age 12 (7 observed vs. 1.7 expected, SIR ϭ 4.1, 95% CI 1.6-8.4), but declined significantly with older ages at T/A. While our data suggest a small increase in HD among all patients undergoing T/A and a significant excess for those under age 12 at surgery, we cannot exclude the possibility that the excess may be due to factors underlying the disorders that led to surgery. Int. J.

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History of tonsillectomy and appendectomy in Hodgkin's disease

Cited by 14 publications

References 27 publications

Tonsillectomy and inflammatory bowel disease: a meta‐analysis

Tonsillectomy and inflammatory bowel disease: a meta‐analysis

Tonsillitis, tonsillectomy and Hodgkin's lymphoma

Risk of Hodgkin's disease subsequent to tonsillectomy: A population-based cohort study in Sweden

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