HIV-1 and HIV-2 Infection in Children in Abidjan, C??te d??lvoire

Natural History of Human Immunodefiency Virus Type 1 Infection in Children: A Five-Year Prospective Study in Rwanda

“…In HIV-1-infected children, the most frequently observed clinical signs were chronic cough, failure to thrive, and generalized lymphadenopathy, which also were reported among the most frequent HIVrelated conditions in other developing countries. 15,16,24,25 Chronic cough and failure to thrive were present in almost half of the initial patterns of symptomatic disease in our series. However, these three conditions were also common in uninfected children.…”

“…Most published data concerning pediatric HIV infection in developing countries have been either prospective studies that focused primarily on mother-to-child HIV transmission and thus reported limited follow-up of children born to HIV-infected women [13][14][15][16][17][18][19][20][21] or nonprospective studies focusing on HIV-infected children. [22][23][24][25][26] Thus, despite the large body of information that has been accumulated on mother-to-child HIV transmission, only a few prospective studies, focusing specifically on natural history in HIV-infected children, have been published in developing countries. 27,28 However, such comparative and prospective studies represent the only approach to identify and evaluate the frequency of early and nonspecific clinical or laboratory findings in infected children.…”

Transmission of HIV-1 infection in sub-Saharan Africa and effect of elimination of unsafe injections

“…Of ten HIV-1-infected children aged 5-12 years, six had a mother who was infected or who had died from AIDS, one was probably infected through a blood transfusion, one possibly through unsafe injections, and in the remaining two the route of transmission remained unclear. Also, the findings of a study 38 of motherchild pairs in Cote d'Ivoire showed that, of 20 infected children aged 15 months or older, 16 had an infected mother and the remainder had received a blood transfusion.…”

Differences of HIV Envelope Protein between HIV-1 and HIV-2: Possible Relation to the Lower Virulence of HIV-2

“…(3) The rate of development of a decreased CD4+ lymphocyte count is approximately 1% per year for HIV-2 versus approximately 10% per year for HIV-1. (4) The rate of development of AIDS is less than 0.5% per year for HIV-2 versus 3% to 5% per year for HIV-1 (1,12,18,29,30,38). Furthermore, Travers et al.…”