HIV‐1 genotype is independently associated with immunodeficiency progression among Chinese men who have sex with men: an observational cohort study

Liang, Yuanhao; Han, Zhigang; Shui, Jingwei; Cheng, Weibin; Zhong, Fei; Cai, Qundi; Wang, H; Wu, Hao; Xu, Huifang; Tang, Shixing

doi:10.1111/hiv.12823

Cited by 8 publications

(12 citation statements)

References 24 publications

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“…More importantly, the risk group and age compositions of 07&08&C and CRF01_AE infected cases were quite similar (data not shown), suggesting the co-circulation of CRF01_AE and 07&08&C strains in similar population in Harbin. Extensive studies have demonstrated CRF07_BC infection exhibits a slow disease progression [34]. Consistent with this, our data indicated both median CD4 count and the proportion of CD4hi cases in 07&08&C cases were much higher than those in CRF01_AE cases.…”

Section: Discussionsupporting

confidence: 90%

“…Several cohort studies in China have demonstrated that HIV-1 genotype was the independent variable associated with disease progression. CRF01_AE infection is commonly associated to lower baseline CD4 count, more rapid CD4 count decline and faster progression to immunode ciency than non-CRF01_AE infection in China [34][35][36]. Consistent with the above ndings, in this study, relative to non-CRF01_AE infection, CRF01_AE infection in Harbin had signi cantly lower odds of being CD4hi case.…”

Section: Discussionsupporting

confidence: 86%

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Young MSM Population Is Changing HIV Epidemic Pattern in Northeast China: a Seven-year Cross-sectional Study

Wang

Liu

et al. 2021

Preprint

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Background: Human immunodeficiency virus type 1 (HIV-1) epidemic in China is featured by geographical diversity of epidemic patterns. Understanding the characteristics of regional HIV epidemic allows carrying out targeted prevention and control measures. However, in some regions of Northeast China, current HIV-1 epidemic feature is largely unknown.Methods: Information of 1006 newly diagnosed HIV-1 infected participants were collected before antiretroviral therapy during 2010-2016 in Harbin city of Northeast China. HIV-1 genotype was identified based on the viral gag and env genes. Comparison analyses were made among different participant groups and sampling time periods to understand HIV-1 epidemic trend. Multivariable logistic regression was used to evaluate the factors associated with immune status of participants.Results: Homosexual contact among men who have sex with men (MSM) was the main transmission route and CRF01_AE was the most dominant HIV-1 genotype. Newly diagnosed cases were getting younger, which was mainly due to the continuous increase in the proportion of young cases (aged < 30 years) among CRF01_AE-infected individuals, especially the CRF01_AE-infected MSM. The proportion of cases with good immune status (CD4 count > 500 cells/μl) continued to increase, and younger in age, HIV-1 infection via homosexual contact among MSM and infection by non-CRF01_AE genotype were positive factors for the good immune outcome.Conclusions: Young MSM have become a new vulnerable group for HIV-1 transmission in Northeast China. This group is changing local HIV-1 epidemic pattern. Measures for preventing and controlling HIV-1 infection among this population are urgently needed in the future.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 86%

Young MSM Population Is Changing HIV Epidemic Pattern in Northeast China: a Seven-year Cross-sectional Study

Wang

Liu

et al. 2021

Preprint

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“…Previous studies showed slower disease progression in subjects infected with CRF07_BC than subtype B or CRF01_AE [6,8,10,40]. Further investigation indicated that the above clinical findings may be associated with the deletion of 7-aa ( 30 PIDKELY 36 ) in p6 Gag [6,8].…”

Section: Discussionmentioning

confidence: 83%

“…Previous studies indicated that patients infected with the CRF07_BC Δ7 variant exhibited lower viral loads and slower disease progression compared with individuals infected with HIV-1 subtype B or CRF01_AE [6][7][8][9][10]. Previous in vitro studies showed that HIV-1 isolates and the infectious clone of CRF07_BC with the Δ7 mutation displayed relatively lower replication capacity and slower replication kinetics than HIV-1 subtype B or Thai B' [7,8].…”

mentioning

confidence: 99%

Elucidation of the Molecular Consequences of Two Unique p6Gag Mutations Derived from HIV-1 CRF07_BC-infected Patients

Cheng

Ablan²,

Freed³

et al. 2020

Preprint

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Background We previously observed that individuals infected with HIV-1 CRF07_BC showed slower disease progression than those infected with HIV-1 subtype B or CRF01_AE. CRF07_BC viruses carry two unique mutations in the p6 Gag protein: insertion of PTAPPE sequences downstream of the original Tsg101 binding domain, and deletion of a seven-amino-acid sequence ( 30 PIDKELY 36 ) that partially overlaps with the Alix binding domain. To further define the role of these mutations in virus release and replication, we introduced them into the HIV-1 proviral clone pNL4-3 for functional characterization. Results We found that the seven-amino-acid deletion, but not the PTAPPE insertion, significantly decreased virus release, Gag processing, and virus infectivity. The seven-amino-acid deletion also resulted in a virus replication defect in both T-cell lines and peripheral blood mononuclear cells. We found that these defects were caused by the seven-amino-acid deletion in p6 Gag , especially deletion of Tyr-36 of p6 Gag , not the deletion of the overlapping p6* sequence in the HIV-1 GagPol protein. The p6 Gag deletion mutant was resistant to a dominant-negative Alix fragment, suggesting a loss of binding between p6 Gag and Alix. Conclusions Our results indicate that the patient-derived seven-amino-acid deletion in p6 Gag of HIV-1 CRF07_BC virus affects virus release, infectivity and replication capacity by disrupting the interaction between HIV-1 p6 Gag and host protein Alix. These results may explain the slower disease progression observed in the subjects infected with HIV-1 CRF07_BC bearing this unique mutation.

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“…This part of the population has the ability to cause widespread transmission of CRF08_BC. Just like since CRF07_BC was first discovered, it has spread rapidly among China provinces through the MSM population [44]. Taken together, these results indicated that prioritizing IDUs, MSM groups, lower education and young person's intervention was likely to be significantly effective in preventing spread of CRF08_BC [5,6,45].…”

Section: Factors Correlated With Clusteringmentioning

confidence: 99%

Using molecular transmission networks to understand the epidemic characteristics of HIV-1 CRF08_BC across China

Liu

Chen

et al. 2021

Emerging Microbes & Infections

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HIV-1 CRF08_BC has become a major epidemic in heterosexuals and intravenous drug users (IDUs) in southern China. In order to evaluate the trends of its epidemic and facilitate targeted HIV prevention, we calculated pairwise genetic distance and constructed the genetic transmission networks based on its pol sequences, derived from the National HIV Molecular Epidemiology Survey. We conducted retrospective network analyses to evaluate changes in inferred clusters over time and studied the epidemic and demographic correlates with transmission networks. Of the 1,829 study subjects, 639 (34.9%) were clustered in 151 transmission networks. A trend of decrease in HIV-1 CRF08_BC infected people clustering in the transmission network was noticed with time. Factors associated with increased clustering include IDUs, heterosexual men, young adults and people with lower education (P<0.05 for all). The IDUs, MSM, young adult and person with low education had more potential transmission links as well (P<0.05 for all). The most crossover links were found between heterosexual women and IDUs, with 30.9% heterosexual women linked to IDUs and 45.4% IDUs to heterosexual women. The crossover links heterosexual women were mainly those with middle age and single (P<0.001). This study indicated that the HIV-1 CRF08_BC epidemic was still on going in China with more than one third of the infected people clustered in the transmission networks. Meanwhile, the study could help identify the active CRF08_BC spreader in the local community and greatly facilitate précising AIDS prevention with targeted intervention.

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HIV‐1 genotype is independently associated with immunodeficiency progression among Chinese men who have sex with men: an observational cohort study

Cited by 8 publications

References 24 publications

Young MSM Population Is Changing HIV Epidemic Pattern in Northeast China: a Seven-year Cross-sectional Study

Young MSM Population Is Changing HIV Epidemic Pattern in Northeast China: a Seven-year Cross-sectional Study

Elucidation of the Molecular Consequences of Two Unique p6Gag Mutations Derived from HIV-1 CRF07_BC-infected Patients

Using molecular transmission networks to understand the epidemic characteristics of HIV-1 CRF08_BC across China

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