HIV-1 infection and cognitive impairment in the cART era: a review

Schouten, Judith; Cinque, Paola; Gisslén, Magnus; Reiss, Peter; Portegies, Peter

doi:10.1097/qad.0b013e3283437f9a

Cited by 221 publications

(205 citation statements)

References 186 publications

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“…Among HIVinfected individuals, problematic alcohol use is associated with worse HIV health outcomes [e.g., 2,5,7,8,[11][12][13][14][15][16][17][18][19] which ostensibly result in increased HIV symptom severity and lower overall quality of life. Adding to the clinical profile, HIV disease progression (i.e., heightened symptom burden) is commonly associated with neurocognitive impairment [24][25][26][27][28]. Given the high prevalence of alcohol problems among HIV-infected individuals coupled with its observed negative impact on memory functioning, routine screening for problematic alcohol use in HIV care settings is thus imperative [14,89].…”

Section: Discussionmentioning

confidence: 99%

“…Of note, cognitive impairment, and memory dysfunction more specifically, is associated with worse treatment outcomes among HIV-infected individuals [27,[32][33][34] and is known to reduce the effectiveness of interventions aimed at optimizing adherence and reducing risk behavior [35]. Memory dysfunction has also been observed among individuals with heavy drinking and alcohol use disorders [36,37] and these changes can persist even following an extended period of abstinence [38,39].…”

Section: Introductionmentioning

confidence: 99%

“…HIV disease progression poses significant risk for compromised cognitive efficiency (e.g., executive dysfunction) and memory functioning (as indexed by neuropsychological testing) [24][25][26][27][28], and although antiretroviral therapy (ART) can reduce neurocognitive impairment [29], mild forms still persist in a large proportion of individuals with HIV [30,31]. Of note, cognitive impairment, and memory dysfunction more specifically, is associated with worse treatment outcomes among HIV-infected individuals [27,[32][33][34] and is known to reduce the effectiveness of interventions aimed at optimizing adherence and reducing risk behavior [35].…”

Section: Introductionmentioning

confidence: 99%

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Problematic Alcohol Use Among Individuals with HIV: Relations with Everyday Memory Functioning and HIV Symptom Severity

et al. 2013

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Problematic alcohol use has been shown to negatively impact cognitive functions germane to achieving optimal HIV health outcomes. The present study, a secondary data analysis, examined the impact of problematic alcohol use on aspects of everyday memory functioning in a sample of 172 HIV-infected individuals (22 % female; M age = 48.37 years, SD = 8.64; 39 % Black/nonHispanic). Additionally, we tested whether self-reported memory functioning explained the relation between problematic alcohol use and HIV symptom severity. Results indicated that problematic patterns of alcohol use were associated with lower total memory functioning, retrieval (e.g., recall-difficulty) and memory for activity (e.g., what you did yesterday) and greater HIV symptom severity. Memory functioning mediated the relation between problematic alcohol use and HIV symptom severity. However, the direction of this relation was unclear as HIV symptom severity also mediated the relation between problematic alcohol use and memory functioning. Findings highlight the importance of integrated care for HIV and alcohol use disorders and suggest that routine alcohol and cognitive screenings may bolster health outcomes among this vulnerable population.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Problematic Alcohol Use Among Individuals with HIV: Relations with Everyday Memory Functioning and HIV Symptom Severity

et al. 2013

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“…Combination ART has yielded enormous benefits for HIVassociated neurocognitive disorders (HAND), as it has for systemic HIV disease [43], though, as we shall see, there are several important caveats and special situations. As with all neurological syndromes, neurocognitive impairment in HIV deserves a diagnostic evaluation before treatment is initiated.…”

Section: Combination Art and Treatment Of Hiv-associated Neurocognitimentioning

confidence: 99%

Update and New Directions in Therapeutics for Neurological Complications of HIV Infections

Ellis

Letendre

2016

Neurotherapeutics

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“…Karena biasanya perangkat tes tersebut cakupannya cukup luas dan membutuhkan banyak waktu, maka dibutuhkan suatu alat skrining yang cepat untuk evaluasi defisit neurokognitif. 5 Mini Mental State Examination (MMSE) dan Clock Drawing Test (CDT) merupakan tes kognitif yang telah diketahui secara luas. MMSE penting untuk menentukan derajat fungsi kognitif secara umum dan untuk skrining penurunan fungsi kognitif.…”

Section: Pendahuluanunclassified

THE PROFILE OF COGNITIVE FUNCTION OF PATIENTS OF HIV/AIDS TREATED IN Dr. SAIFUL ANWAR MALANG HOSPITAL

Harahap

Rianawati

2015

MNJ

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ABSTRAKLatar belakang. HIV/AIDS menyebabkan terjadinya imunodefisiensi seluler (deplesi sel CD4+). Hal ini menyebabkan terjadinya berbagai komplikasi, diantaranya adalah gangguan kognitif berupa HIVassociated dementia (HIV-D). Tujuan. Untuk mengetahui profil fungsi kognitif penderita HIV/AIDS yang dirawat di Rumah Sakit Dr. Saiful Anwar Malang (RSSA). Metode. Penelitian deskriptif dengan menggunakan desain cross-sectional, dilakukan terhadap 41 penderita HIV/AIDS yang dirawat di RSSA selama bulan Januari -Februari 2012 (n=41). Pemeriksaan fungsi kognitif dilakukan dengan menggunakan instrumen Mini Mental State Examination (MMSE) dan Clock Drawing Test (CDT). Hasil. Pada pemeriksaan MMSE, jumlah penderita dengan nilai MMSE 0-16 adalah sebanyak 9 orang (21,95 %), jumlah penderita dengan nilai MMSE 17-23 adalah 25 orang (60,98 %), dan penderita dengan nilai MMSE 24-30 adalah 7 orang (17,07 %). Pada pemeriksaan CDT, 37 penderita terindikasi untuk dilakukan evaluasi lanjutan (nilai CDT ≤ 3) dan 4 penderita lainnya menunjukkan fungsi kognitif normal (nilai CDT = 4). Seluruh penderita dengan nilai tes MMSE dan CDT dibawah normal memiliki kadar CD4 rendah (< 200 sel/µL). Penderita yang menunjukkan fungsi kognitif normal pada pemeriksaan CDT juga menunjukkan hasil yang sama pada pemeriksaan MMSE. Simpulan. Sebagian besar penderita HIV/AIDS dalam penelitian ini menunjukkan adanya penurunan fungsi kognitif. Kata kunci: HIV/AIDS, fungsi kognitif, MMSE, CDT ABSTRACT Background. HIV/AIDS caused cellular immunodeficiency (the depletion of CD4+). This, in turn, raised many complications, such as HIV-associated dementia (HIV-D). Objective. To know the profile of cognitive function of patients of HIV/AIDS tretaed in

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HIV-1 infection and cognitive impairment in the cART era: a review

Cited by 221 publications

References 186 publications

Problematic Alcohol Use Among Individuals with HIV: Relations with Everyday Memory Functioning and HIV Symptom Severity

Problematic Alcohol Use Among Individuals with HIV: Relations with Everyday Memory Functioning and HIV Symptom Severity

Update and New Directions in Therapeutics for Neurological Complications of HIV Infections

THE PROFILE OF COGNITIVE FUNCTION OF PATIENTS OF HIV/AIDS TREATED IN Dr. SAIFUL ANWAR MALANG HOSPITAL

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