HIV-1 subtypes and drug resistance profiles in a cohort of heterosexual patients in Istanbul, Turkey

Köksal, Muammer Osman; Beka, Hayati; Lübke, Nadine; Verheyen, Jens; Eraksoy, Haluk; Çağatay, Atahan; Kaiser, Rolf; Akgül, Baki; Ağaçfidan, Ali

doi:10.1007/s00430-015-0419-9

Cited by 4 publications

(2 citation statements)

References 36 publications

(41 reference statements)

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“…In prior studies, HIV was reported in 6.7%-15.1% of patients (15,27). Although the HIV infection rate has increased in recent decades, the overall HIV prevalence is still low compared with that in Western countries (28)(29)(30). This discrepancy may be due to the low prevalence of HIV in general (7,29).…”

Section: Discussionmentioning

confidence: 96%

“…Although the HIV infection rate has increased in recent decades, the overall HIV prevalence is still low compared with that in Western countries (28)(29)(30). This discrepancy may be due to the low prevalence of HIV in general (7,29). There is no national screening program for anal cancer and anal precancerous lesions in HIV-positive patients.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Real world survival data of a rare malignancy: Anal cancer results in HIV negative patients from Turkey

Esin

Yıldız

Laçin

et al. 2018

Turk J Gastroenterol

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Real world survival data of a rare malignancy: Anal cancer results in HIV negative patients from Turkey

Esin

Yıldız

Laçin

et al. 2018

Turk J Gastroenterol

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Prevalence of K65R in patients treated with tenofovir disoproxil fumarate: recommendations based on the Frankfurt HIV Cohort Study Resistance Database (FHCS-RD)

Reinheimer

Wesner

Keppler

et al. 2016

Med Microbiol Immunol

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Mutations in the genome of HIV-1 can compromise the success of antiretroviral treatments (ARTs) in HIV-1-infected individuals. The Frankfurt HIV Cohort Study Resistance Database (FHCS-RD) has previously documented a decline in the burden of resistance-associated mutations (RAMs) following the implementation of several new antiretroviral therapy regimens in 2007. In the current study, the annual burden of RAMs documented in the FHCS-RD in 2005-2013 was set in relation to the annual number of all cohort patients, drug regimens, available resistance tests, and prevalence for each RAM on relevant codons of reverse transcriptase (RT) and protease (PR) genes. A specific focus was put on the prevalence of the tenofovir disoproxil fumarate (TDF) signature mutation K65R in HIV-1 RT in relation to the application of TDF within ART. Between 2005 and 2012, a total of 4423 HIV genotyping data sets from 4509 patients were analysed. All mutations show a consistent decline, and the most impressive decrease was observed for thymidine analogue mutations (TAMs). The frequency of non-TAMs and PR mutations also decreased, but generally to a lower extent. The prevalence of K65R decreased from 2.6 % in 2005 to 0.2 % in 2012 despite increased use of TDF-containing ART. Both the improved strategic use of TDF in ARTs and generally more effective ART regimens may have resulted in decreasing RAM prevalences in FHCS-RD since 2007. These trends challenge the cost-effectiveness of resistance testing prior to failing ART.

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HIV-1 replication in central nervous system increases over time on only protease inhibitor therapy

Donath

Wolf

Stürmer

et al. 2016

Med Microbiol Immunol

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There are concerns about central nervous system (CNS)-replication of HIV-1 in patients on boosted protease inhibitors. Purpose of this study was to compare HIV-1 viral loads (VLs) from patients treated with only boosted dual protease inhibitor (bdPI), versus combination antiretroviral therapy (cART group), containing two nucleoside analogue reverse transcriptase inhibitors (NRTI) and a third partner. All patients from a large German HIV-treatment cohort with available medication, clinical and demographic data, including results from simultaneous HIV-1 viral load (VL) assessments in cerebrospinal fluid (CSF) and blood plasma, were retrospectively evaluated as controlled cross-sectional study. CSF had been obtained from patients with variable neurological symptoms during 2005-2014. Statistical analysis comprised nonparametric tests, regression and correlation techniques accounting for undetectable quantifications. Statistical analysis comprised nonparametric tests, regression and correlation techniques accounting for undetectable quantifications. Overall, 155 patients were evaluable (bdPI: 24; cART: 131). At time of CSF-collection, both groups were comparable in age, gender, CD4-cell counts, or primary HIV-transmission risks, though bdPI patients were clinically more advanced. The proportion of patients with undetectable HIV-1 (<50 copies/ml) in CSF was lower for bdPI group (25 vs 49.6 %; p = 0.026), but similar in plasma (46 vs 41 %). Median CSF-VL was higher in bdPI group (600 vs 50 copies/ml; p = 0.027) and similar in plasma. Mean VL CSF/plasma ratio was 342.91 for bdPI- and 54.48 for cART patients (p < 0.001). Pearson's regression analysis revealed a trend for an elevated VL-ratio over time within bdPI group. HIV-1 replication was higher and more frequently detectable in CSF from bdPI patients, indicating a worse CNS penetration effectiveness of used boosted PI. Within bdPI group, measured CNS-viral replication was increasing over time, suggesting an over time impaired HIV-1 suppression in CSF.

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HIV-1 subtypes and drug resistance profiles in a cohort of heterosexual patients in Istanbul, Turkey

Cited by 4 publications

References 36 publications

Real world survival data of a rare malignancy: Anal cancer results in HIV negative patients from Turkey

Real world survival data of a rare malignancy: Anal cancer results in HIV negative patients from Turkey

Prevalence of K65R in patients treated with tenofovir disoproxil fumarate: recommendations based on the Frankfurt HIV Cohort Study Resistance Database (FHCS-RD)

HIV-1 replication in central nervous system increases over time on only protease inhibitor therapy

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