HIV and conjunctival malignancies

Kestelyn, Philippe; Stevens, Anne-Maria; Ndayambaje, A.; Hanssens, M; Perre, Philippe Van de

doi:10.1016/0140-6736(90)91562-o

Cited by 67 publications

(39 citation statements)

References 7 publications

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“…Studies from Africa (Kestelyn et al, 1990;Ateenyi-Agaba, 1995;Waddell et al, 1996) and the USA (Goedert and Cote, 1995) have confirmed this association (Table I). Although each study is small, they show remarkably consistent results (summary OR= 13.0, 95% CI 7.2-23.1; derived from weighted averages of the log relative risks).…”

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confidence: 65%

“…Two case reports of squamous cell carcinoma of the conjunctiva in HIV-seropositive males in the USA (Winward and Curtin, 1989;Kim et al, 1990), coupled with a dramatic increase in the numbers of tumours being seen by ophthalmologists in at least two African centres (Kestelyn et al, 1990;Ateenyi-Agaba, 1995), led to the suggestion of an association with HIV. Studies from Africa (Kestelyn et al, 1990;Ateenyi-Agaba, 1995;Waddell et al, 1996) and the USA (Goedert and Cote, 1995) have confirmed this association (Table I).…”

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confidence: 99%

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A review of the aetiology of squamous cell carcinoma of the conjunctiva

Newton¹

1996

Br J Cancer

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confidence: 65%

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confidence: 99%

A review of the aetiology of squamous cell carcinoma of the conjunctiva

Newton¹

1996

Br J Cancer

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“…In Uganda, a study done found a prevalence of 71% while in Malawi, this was 86% [8,9] . A case control study in Rwanda also demonstrated that HIV infection is a risk factor for the development of squamous cell dysplasia and neoplasia of the conjunctiva [7] . These findings are all similar and suggest a strong association between HIV and squamous cell carcinoma of the conjunctiva.…”

Section: Discussionmentioning

confidence: 97%

“…There have been reports documenting a recent increase in its incidence especially in equatorial Africa [7,8] . A combination of risk factors such as intense exposure to ultraviolet light, HIV-induced immunosuppression resulting in reduction in the effectiveness of the immune surveillance system and coinfection with the human papilloma virus is believed to hasten its development [9] .…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of HIV seropositivity among patients with squamous cell carcinoma of the conjunctiva

Osahon

Ukponmwan

Uhunmwangho

2011

Asian Pacific Journal of Tropical Biomedicine

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Human Immunodeficiency Virus Infection, Bcl-2, p53 Protein, and Ki-67 Analysis in Ocular Surface Squamous Neoplasia

Mahomed

Chetty²

2002

Arch Ophthalmol

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Objectives:To determine the age and human immunodeficiency virus (HIV) status of patients with ocular surface squamous neoplasia (OSSN), and to analyze tumor proliferation, Bcl-2, and p53 oncoprotein expression in OSSN. Methods:Only patients with histologically proved neoplasia were included in this study. The HIV status was obtained only with informed consent. Monoclonal antibodies to p53 and Bcl-2 protein were used after microwave antigen retrieval to enhance immunohistochemical staining of the sections. Proliferation was assessed by means of Ki-67 antigen expression. Positive staining in each specimen was expressed as a percentage and graded accordingly.Results: Forty-one eyes in 40 black patients with a mean age of 37 years were found to have OSSN. Of the 41 le-sions, 35 represented in situ or invasive carcinoma. The remaining 6 had mild or moderately dysplastic lesions. Seventeen patients agreed to an HIV test and, of these, 12 (70.6%) were HIV positive. All 12 were younger than 50 years, and 11 had either carcinoma in situ or invasive lesions. Twenty-two of 40 lesions expressed significant (greater than 50% of neoplastic cells) p53 positivity, while Bcl-2 expression was detected in 10. Ki-67 expression was low, even in the HIV-positive lesions.Conclusions: At our institution, OSSN occurs in young patients, many of whom are HIV positive. Expression of p53 is a common finding, whereas Bcl-2 immunoexpression occurs in the minority of cases. Ki-67 analysis showed that OSSN is a slow-growing tumor, even in the presence of HIV infection.

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HIV and conjunctival malignancies

Cited by 67 publications

References 7 publications

A review of the aetiology of squamous cell carcinoma of the conjunctiva

A review of the aetiology of squamous cell carcinoma of the conjunctiva

Prevalence of HIV seropositivity among patients with squamous cell carcinoma of the conjunctiva

Human Immunodeficiency Virus Infection, Bcl-2, p53 Protein, and Ki-67 Analysis in Ocular Surface Squamous Neoplasia

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