HIV-associated Follicular Bronchiolitis

Shipe, Ryan; Lawrence, Jason; Green, Jeffery; Enfield, Kyle B.

doi:10.1164/rccm.201206-1096im

Cited by 13 publications

(5 citation statements)

References 5 publications

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“…Follicular bronchiolitis observed in HIV disease has been shown to improve with initiation of anti-retroviral drugs. 7 On the other hand, when we look at bronchiolitis patterns reported in PCD, follicular bronchiolitis has not been reported. The first case of diffuse panbronchiolitis (DPB) occurring in association with PCD in Japan was reported in 1969.…”

Section: Discussionmentioning

confidence: 94%

Follicular Bronchiolitis in Primary Ciliary Dyskinesia

Thalanayar¹,

Holguín²

2014

AMJ

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Ciliary dysfunction in primary ciliary dyskinesia (PCD) may be associated with bronchiolitis. Diffuse bronchiolitis has been reported in a subset of PCD patients who have Kartagener's syndrome in Japan. We report a case of follicular bronchiolitis (FB) in a case of PCD presenting with recurrent episodes of cough, dyspnea, and bronchiectasis. This may motivate researchers to study rarer variants and presentations in PCD.

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Section: Discussionmentioning

confidence: 94%

Follicular Bronchiolitis in Primary Ciliary Dyskinesia

Thalanayar¹,

Holguín²

2014

AMJ

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“…There was a satisfactory clinical and radiological response on cART 20. Finally, Shipe et al 18 presented a 38-year-old African American HIV-infected man (CD4+ count: 347 cells/µL, VL: 633 000 copies/mL and never on cART) who presented with several months of non-productive cough and radiology featuring miliary nodules. He was thoroughly examined, and there were no signs of TB, disseminated fungal disease or viral or bacterial pneumonia.…”

Section: Discussionmentioning

confidence: 98%

Follicular bronchiolitis in an HIV-infected individual on combination antiretroviral therapy with low CD4+ cell count but sustained viral suppression

et al. 2017

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A 36-year-old Danish man, living in Asia, was diagnosed with pneumonia (PCP) and HIV in 2013 (CD4+ count: 6 cells/µL; viral load: 518 000 copies/mL). He initiated combination antiretroviral therapy. Later that year, he was also diagnosed with granulomatosis with polyangiitis and was treated with prednisolone. Despite complete viral suppression and increasing CD4+ count (162 cells/µL), he was readmitted with PCP in April 2015. Subsequently, he returned to Denmark (CD4+ count: 80 cells/µL, viral suppression). Over the following months, he developed progressive dyspnoea. Lung function tests demonstrated severely reduced lung capacity with an obstructive pattern and a moderately reduced diffusion capacity. High resolution computer tomography revealed minor areas with tree-in-bud pattern and no signs of air trapping on expiratory views. Lung biopsy showed lymphocytic infiltration surrounding the bronchioles with sparing of the alveolar septa. He was diagnosed with follicular bronchiolitis. The patient spontaneously recovered along with an improvement of the immune system.

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“…Treatment strategies include management of the underlying or associated disease, such as immunosuppressive therapy for autoimmune disease. Initiating antiretroviral therapy in a patient with HIV-associated FB has shown improvement in respiratory symptoms [11]. In patients with CVID, intravenous immunoglobulin replacement therapy has been used, as well as immunotherapy with rituximab and azathioprine to good result [12,13].…”

Section: Discussionmentioning

confidence: 99%

Follicular Bronchiolitis: Two Cases with Varying Clinical and Radiological Presentation

Garg

Mody

Pal

et al. 2020

Case Reports in Pulmonology

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Follicular bronchiolitis (FB) is a rare bronchiolar disorder associated with hyperplasia of the bronchial-associated lymphoid tissue (BALT). It is characterized by the development of lymphoid follicles with germinal centers in the walls of small airways. It falls under the category of lymphoproliferative pulmonary diseases (LPDs) and commonly occurs in relation to connective tissue disease, immunodeficiency, infections, interstitial lung disease (ILD), and inflammatory airway diseases. Computerized tomography (CT) findings include centrilobular nodules with patchy ground glass infiltrate, tree-in-bud findings, and air trapping. It can very rarely present as diffuse cystic lung disease. We present two cases of FB. The first case is associated with Human Immunodeficiency Virus (HIV) infection and asthma with diffuse cystic changes on the CT. The second case is associated with reactive airway disease and gastroesophageal reflux disease (GERD) with the classic centrilobular nodules and ground glass opacities on the CT.

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HIV-associated Follicular Bronchiolitis

Cited by 13 publications

References 5 publications

Follicular Bronchiolitis in Primary Ciliary Dyskinesia

Follicular Bronchiolitis in Primary Ciliary Dyskinesia

Follicular bronchiolitis in an HIV-infected individual on combination antiretroviral therapy with low CD4+ cell count but sustained viral suppression

Follicular Bronchiolitis: Two Cases with Varying Clinical and Radiological Presentation

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