HIV infection: epidemiology, pathogenesis, treatment, and prevention

Maartens, Gary; Celum, Connie; Lewin, Sharon R.

doi:10.1016/s0140-6736(14)60164-1

Cited by 680 publications

(615 citation statements)

References 161 publications

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“…2 However, HIV-1 epidemic remains unsolved, and there is still no cure for HIV-1 infection, as well as a lack of valid HIV-1 vaccines (1). The HAART regimen remains the most effective treatment, but this only blocks active HIV-1 replication, leaving residual viraemia in most AIDS patients (2,3).…”

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confidence: 99%

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FACT Proteins, SUPT16H and SSRP1, Are Transcriptional Suppressors of HIV-1 and HTLV-1 That Facilitate Viral Latency

Huang

Santoso

Power

et al. 2015

Journal of Biological Chemistry

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Background: FACT proteins SUPT16H and SSRP1 are identified as host factors that restrict HIV-1 replication. Results: Biochemical and genetic evidences that SUPT16H and SSRP1 affect HIV-1/HTLV-1 transcription and latency are provided. Conclusion: SUPT16H and SSRP1 suppress transcription of HIV-1/HTLV-1, and their presence may promote HIV-1 latency. Significance: Identification of host factors necessary for HIV-1 latency is critical, which may benefit the development of novel HIV-1 latency-reversing agents.

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confidence: 99%

“…The authors declare that they have no conflicts of interest with the contents of this article. 1 To whom correspondence should be addressed: Dept. lular mechanisms facilitate HIV-1 latency, mostly through suppression of transcription.…”

mentioning

confidence: 99%

FACT Proteins, SUPT16H and SSRP1, Are Transcriptional Suppressors of HIV-1 and HTLV-1 That Facilitate Viral Latency

Huang

Santoso

Power

et al. 2015

Journal of Biological Chemistry

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“…Statistical data in Indonesia through 2014 shows that there are more than 100,000 HIV patients. [1], [2] Mucocutaneous disorders occur in most cases of HIV during the course of diseases including genital ulcers. [3] Genital ulcer has become a dilemmatic case.…”

Section: Introductionmentioning

confidence: 99%

Genital Ulcers in Women with HIV Proposed Revision on Management Algoritm

Mochtar¹

2017

AJLS

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Abstract:More than 100,000 people has been infected by HIV (Human Immunodeficiency Virus) in Indonesia.Mucocutaneous disorders occur in most patients with HIV during the course of the disease, it is caused by acquired immunodeficiency or the effects of the HIV therapy. One of the most important clinical manifestations is genital ulcers. A specific attention is needed to identify the clinical manifestations of genital ulcers in HIV patients to find the etiology so that the treatment of the case can be more appropriate. There are 4 cases of genital ulcers in women with AIDS (Acquired Immune Deficiency Syndrome). Both VDRL test (Venereal Disease Reseach Laboratory) and TPHA (Trepenoma pallidum Haemagglutination) test gave negative results. Two cases has successful therapy with acyclovir 400 mg three times for 2 weeks. Test results for herpes simplex antibodies is 2 positive. The incidence of genital ulcers, especially in the chronic form, increases along with the incidence of the growing AIDS epidemic. A prospective study in Paris shows that the most common cause of genital ulcers in patients with AIDS is syphilis. All of these four cases have negative results of VDRL and TPHA, so it is necessary to consider another diagnosis as the cause of genital ulcers in immunocompromised patients that often give atypical clinical symptoms. The accuracy of the diagnosis is necessary to provide adequate treatment, especially in immunocompromised patient.

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“…While tremendous progress has been made in scaling up access to treatment, with covering up to 61 % of those eligible for treatment in 2012 [1], it is estimated that only 65 % of people living with HIV (PLHIV) in sub-Saharan Africa who initiate treatment remain on it after 3 years [2,3]. Globally, HIV prevalence is increasing as AIDS-related deaths decrease because those receiving treatment are living longer healthier lives [4]. This means that long-term adherence and retention in care and treatment will be a challenge because if all the new WHO guideline recommendations were implemented globally, the number of people eligible for antiretroviral therapy will increase from 16.7 to 28.6 million in 2013 representing 86 % of all PLHIV in low-and middleincome countries [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…Globally, HIV prevalence is increasing as AIDS-related deaths decrease because those receiving treatment are living longer healthier lives [4]. This means that long-term adherence and retention in care and treatment will be a challenge because if all the new WHO guideline recommendations were implemented globally, the number of people eligible for antiretroviral therapy will increase from 16.7 to 28.6 million in 2013 representing 86 % of all PLHIV in low-and middleincome countries [4,5]. With this projected increase, adherence and retention, as well as the management and prevention of non-communicable diseases become more important [5,6].…”

Section: Introductionmentioning

confidence: 99%

Adherence to HIV and TB Care and Treatment, the Role of Food Security and Nutrition

2014

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Food security and nutrition play an important role in HIV and TB care and treatment, including for improving treatment outcomes, adherence and uptake of HIV and TB care. This AIDS and behaviour supplement on ''Adherence to HIV and TB care and treatment, the role of food security and nutrition'' provides an overview of the current evidence and knowledge about the barriers to uptake and retention in HIV and TB treatment and care and on whether and how food and nutrition assistance can help overcome these barriers. It contains nine papers on three topic areas discussing: (a) adherence and food and nutrition security in context of HIV and TB, their definitions, measurement tools and the current situation; (b) food and nutrition insecurity as barriers to uptake and retention; and (c) food and nutrition assistance to increase uptake and retention in care and treatment. Future interventions in the areas of food security, nutrition and social protection for increasing access and adherence should be from an HIV sensitive lens, linking the continuum of care with health systems, food systems and the community, complementing existing platforms through partnerships and integrated services.

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HIV infection: epidemiology, pathogenesis, treatment, and prevention

Cited by 680 publications

References 161 publications

FACT Proteins, SUPT16H and SSRP1, Are Transcriptional Suppressors of HIV-1 and HTLV-1 That Facilitate Viral Latency

FACT Proteins, SUPT16H and SSRP1, Are Transcriptional Suppressors of HIV-1 and HTLV-1 That Facilitate Viral Latency

Genital Ulcers in Women with HIV Proposed Revision on Management Algoritm

Adherence to HIV and TB Care and Treatment, the Role of Food Security and Nutrition

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