HIV mother-to-child transmission: A complex genetic puzzle tackled by Brazil and Argentina research teams

Silva, R. Celerino da; Bedin, Elisa; Mangano, A.; Aulicino, Paula; Pontillo, Alessandra; Brandão, Lucas André Cavalcanti; Guimarães, Rafael Lima; Arraes, Luiz Cláudio; L, Sen; Crovella, Sérgio

doi:10.1016/j.meegid.2013.03.005

Cited by 2 publications

(1 citation statement)

References 69 publications

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“…Prior to current prevention strategies, mother-to-child transmission (MTCT) or vertical transmission of HIV-1 occurred at an estimated rate of more than 30%, and still is the major cause of HIV/AIDS in children (Taha, 2011, da Silva et al, 2013). MTCT can occur during pregnancy ( in utero , IU), at the time of delivery (intrapartum, IP), or postpartum (PP) through breast feeding (Duri et al, 2010, Kourtis et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Maternal human leukocyte antigen-G (HLA-G) genetic variants associate with in utero mother-to-child transmission of HIV-1 in Black South Africans

Hong

Paximadis

Gray

et al. 2015

Infection, Genetics and Evolution

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A 14-bp insertion/deletion (indel) within the 3' untranslated region (3’UTR) that affects HLA-G expression has been associated with HIV-1 mother-to-child transmission (MTCT). However, other 3’UTR single nucleotide polymorphisms (SNPs) that influence HLA-G mRNA stability have been described but not analyzed in the context of MTCT, and little is known about the role of HLA-G alleles. We examined HLA-G alleles and 3’UTR SNPs, including the 14-bp indel, in 216 mother-infant pairs from Johannesburg, South Africa. Mother-infant pairs were classified as HIV-1 non-transmitting (NT, n=144) or HIV-1 transmitting (TR, n=72) with either intrapartum (IP, n=29) or in utero (IU, n=19) infected infants. We found HLA-G allele, G*01:01:02 (in strong linkage disequilibrium with the 14-bp insertion) and +3187G SNP were significantly over-represented in IU-TR mothers compared to NT mothers (P=0.036, OR=2.26; P=0.011, OR=2.96, respectively). These findings suggest that maternal HLA-G alleles and/or SNPs that might alter expression of HLA-G potentially influence IU HIV-1 MTCT.

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Section: Introductionmentioning

confidence: 99%

Maternal human leukocyte antigen-G (HLA-G) genetic variants associate with in utero mother-to-child transmission of HIV-1 in Black South Africans

Hong

Paximadis

Gray

et al. 2015

Infection, Genetics and Evolution

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Clinical–Epidemiological Characteristics and IFITM-3 (rs12252) Variant Involvement in HIV-1 Mother-to-Children Transmission Susceptibility in a Brazilian Population

Leandro

Silva

Rodrigues

et al. 2023

Life

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Mother-to-children transmission (MTCT) is the main infection route for HIV-1 in children, and may occur during pregnancy, delivery, and/or postpartum. It is a multifactorial phenomenon, where genetic variants play an important role. This study aims at analyzing the influence of clinical epidemiological characteristics and a variant (rs12252) in interferon-induced transmembrane protein 3 (IFITM-3), a gene encoding an important viral restriction factor, on the susceptibility to HIV-1 mother-to-children transmission (MTCT). A case–control study was performed on 209 HIV-1-infected mothers and their exposed infected (87) and uninfected (122) children from Pernambuco, Brazil. Clinical–epidemiological characteristics are significantly associated with MTCT susceptibility. Transmitter mothers have a significantly lower age at delivery, late diagnosis, deficiency in ART use (pregnancy and delivery), and detectable viral load in the third trimester of pregnancy compared with non-transmitter mothers. Infected children show late diagnosis, vaginal delivery frequency, and tend to breastfeed, differing significantly from uninfected children. The IFITM-3 rs12252-C allele and TC/CC genotypes (dominant model) are significantly more frequent among infected than uninfected children, but the statistical significance does not remain when adjusted for clinical factors. No significant differences are observed between transmitter and non-transmitter mothers in relation to the IFITM-3 variant.

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HIV mother-to-child transmission: A complex genetic puzzle tackled by Brazil and Argentina research teams

Cited by 2 publications

References 69 publications

Maternal human leukocyte antigen-G (HLA-G) genetic variants associate with in utero mother-to-child transmission of HIV-1 in Black South Africans

Maternal human leukocyte antigen-G (HLA-G) genetic variants associate with in utero mother-to-child transmission of HIV-1 in Black South Africans

Clinical–Epidemiological Characteristics and IFITM-3 (rs12252) Variant Involvement in HIV-1 Mother-to-Children Transmission Susceptibility in a Brazilian Population

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