2010
DOI: 10.1089/aid.2010.0046
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HIV Type 1polGene Diversity and Genotypic Antiretroviral Drug Resistance Mutations in Malabo, Equatorial Guinea

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Cited by 21 publications
(22 citation statements)
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References 20 publications
(20 reference statements)
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“…These findings are consistent with previous studies that have reported similar rates of acquired drug resistance mutations in Cameroon (8,23) and other African countries with similar ART programs (10,31,32). The most prevalent mutations identified were M184V and K103N.…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…These findings are consistent with previous studies that have reported similar rates of acquired drug resistance mutations in Cameroon (8,23) and other African countries with similar ART programs (10,31,32). The most prevalent mutations identified were M184V and K103N.…”
Section: Discussionsupporting
confidence: 93%
“…In addition to these challenges, the low genetic barrier of commonly used antiretrovirals (ARV) for first-line treatment further increases the risks of HIVDR mutations. The most prevalent mutations that cause intermediate-to high-level resistance to this first-line regimen in countries such as those in the central African region, including Cameroon, Central African Republic, Gabon, etc., that use the WHO approach are M184V (37% to 90%), T215Y/F (11% to 47.2%), K103N (14% to 44%), and Y181C (9.4% to 19.8%) (8)(9)(10)(11)(12)(13). These can restrict treatment options and increase cost by requiring new and more expensive ARV regimens (36).…”
mentioning
confidence: 99%
“…Two of these patients came from Equatorial Guinea, where CRF02_AG is highly prevalent (12), but the third patient was from North Africa, where subtype B is prevalent (1). The different origins of the patients suggest that the infection and subsequent spread occurred in Spain.…”
Section: One Of 10 Hiv-1-infections In Spain Could Represent Recombinmentioning
confidence: 99%
“…Kijak et al / Drug and Alcohol Dependence xxx (2010) xxx-xxx ing genetic diversity has also been linked to anti-retroviral drug resistance, suggesting that diversity may also play roles in HIV therapeutic outcomes (Djoko et al, 2010). Identifying individuals and sub-groups of populations where dual infections are more frequent and recombinant forms are more likely to arise could help in the design and targeting of preventive interventions aimed at diminishing HIV-1 genetic complexity.…”
Section: Introductionmentioning
confidence: 99%