HL‐A and Disease Associations ‐ A Survey

Mixed lymphocyte cultures in rheumatoid arthritis.

“…Because of the known proximity of the locus controlling strong MLC stimulation to those regulating certain specific immune responses in mice (41) and in rhesus monkeys (42) it is attractive to speculate that an Ir gene may be involved. The rapidly developing knowledge of the HLA chromosomal region which includes also loci for certain complement components (43), cell surface receptors (44), and disease associations (45) would indicate that many other possibilities must be considered. Since many of these possibilities are open to experimental testing with tools already available, further exploration should lead to an understanding of the mechanisms involved in 'Stastny, P. Manuscript in preparation.…”

Association between hla and cutaneous necrotizing venulitis

“…No data of possible HLA vasculitis associations have been presented by others (6,19). BW35 alone has, however, been reported to occur more frequently than expected among black females with SLE (20), but not in Caucasian SLE patients or those with RA, JRA, or Sjogren's syndrome (20)(21)(22).…”

Epidemiology of Hodgkin's Lymphoma

“…These associations suggest that this disease is a result of genetic environmental interaction (Bodmer, 1973;Chakravarti et al, 1986;Robertson et al, 1987& Svejgaard et al, 1975. Also, concordance of Hodgkin's lymphoma in first degree relatives and in parentchild pairs has been noted in many studies (Claser and Jarren, 1996) especially if they are of the same sex.…”