Hl-a Matching in Treatment of Burned Patients With Skin Allografts

Batchelor, J. R.; Hackett, M.E.J.

doi:10.1016/s0140-6736(70)90165-0

Cited by 73 publications

(28 citation statements)

References 13 publications

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“…Apart from the impaired function of the skin, other adversely affected systems may be responsible as well, such as an impaired cellular immunity [8,12,18], The increase in production of immunoglobulins may be positively cor related with the increase of part of the B cell population in the early peri od after the thermal trauma [21], The absence of a primary antibody pro duction against alligator erythrocytes as reported by Alexander and Moncrtf.f [1], might be explained in terms of a possibleT cell dependency of this particular antigen. Studies in vitro showed that the T cell is either qualitatively or quantitatively impaired after thermal trauma [21], Our data seem to substantiate the indication to use bacterial vaccines in burn patients.…”

Section: Discussionmentioning

confidence: 99%

Immimological Studies in Burn Patients

Leguit¹,

Reerink-Brongers²,

Vp³

1973

Int Arch Allergy Immunol

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In 23 thermally injured patients an initial decrease of IgG, IgM, IgA, total serum protein and serum albumin was found, followed by an increased production of all immunoglobulins, including IgE. The alteration in the immunoglobulin pattern was most marked in the severely injured patients. An anamnestic response after a booster injection with tetanus toxoid was observed. There was no rise in the titre of naturally occurring antibodies. No evidence was obtained for impairment of the humoral immune response following thermal trauma.

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Section: Discussionmentioning

confidence: 99%

Immimological Studies in Burn Patients

Leguit¹,

Reerink-Brongers²,

Vp³

1973

Int Arch Allergy Immunol

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“…This example is derived from a study by Batchelor and Hackett [25] of 16 cases of badly burned patients. Each patient was given a number of skin grafts from a variety of donors, the time to graft rejection was recorded.…”

Section: Example 2: Skin Graft Datamentioning

confidence: 99%

Hierarchical likelihood approach for the Weibull frailty model

Ning-ning¹,

Xu²,

Fang³

2011

Journal of Statistical Computation and Simulation

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In this article, the proportional hazard model with Weibull frailty, which is outside the range of the exponential family, is used for analysing the right-censored longitudinal survival data. Complex multidimensional integrals are avoided by using hierarchical likelihood to estimate the regression parameters and to predict the realizations of random effects. The adjusted profile hierarchical likelihood is adopted to estimate the parameters in frailty distribution, during which the first-and second-order methods are used. The simulation studies indicate that the regression-parameter estimates in the Weibull frailty model are accurate, which is similar to the gamma frailty and lognormal frailty models. Two published data sets are used for illustration.

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“…In the simplest situations, subjects may be paired based on date of diagnosis (as was done in the ovarian cancer study in § 1.1), date of entry into the study, or date of random assignment. Alternatively, the pairs may be two temporal measurements for the same person, as was true in Batchelor and Hackett's (1970) much discussed data concerning two different skin grafts on each of 16 severely burned patients. Even if censoring is entirely by the date of data analysis, with no loss to follow-up, pairing of these kinds will tend to produce dependence between the two censoring times for the two paired individuals.…”

Section: Heterogeneous Exchangeable Censoringmentioning

confidence: 99%

Exact, Distribution Free Confidence Intervals for Late Effects in Censored Matched Pairs

Daniel

2009

Biometrical J

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When comparing censored survival times for matched treated and control subjects, a late effect on survival is one that does not begin to appear until some time has passed. In a study of provider specialty in the treatment of ovarian cancer, a late divergence in the Kaplan-Meier survival curves hinted at superior survival among patients of gynecological oncologists, who employ chemotherapy less intensively, when compared to patients of medical oncologists, who employ chemotherapy more intensively; we ask whether this late divergence should be taken seriously. Specifically, we develop exact, permutation tests, and exact confidence intervals formed by inverting the tests, for late effects in matched pairs subject to random but heterogeneous censoring. Unlike other exact confidence intervals with censored data, the proposed intervals do not require knowledge of censoring times for patients who die. Exact distributions are consequences of two results about signs, signed ranks, and their conditional independence properties. One test, the late effects sign test, has the binomial distribution; the other, the late effects signed rank test, uses nonstandard ranks but nonetheless has the same exact distribution as Wilcoxon's signed rank test. A simulation shows that the late effects signed rank test has substantially more power to detect late effects than do conventional tests. The confidence statement provides information about both the timing and magnitude of late effects.

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Hl-a Matching in Treatment of Burned Patients With Skin Allografts

Cited by 73 publications

References 13 publications

Immimological Studies in Burn Patients

Immimological Studies in Burn Patients

Hierarchical likelihood approach for the Weibull frailty model

Exact, Distribution Free Confidence Intervals for Late Effects in Censored Matched Pairs

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