HLA‐A*2312–a novel allele found during testing for the UK NEQAS for H&amp;I DNA HLA‐typing scheme

Hammond, Laura; Bengtsson, Mats; Street, J.; Pepperall, J.; Darke, C.

doi:10.1111/j.1399-0039.2006.00639.x

Cited by 6 publications

(2 citation statements)

References 5 publications

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“…Interestingly, in developed Western nations, where rHSK is more prevalent, the HLA-B*27 allele is more frequent in Caucasoid populations than in North Africans (4%), Chinese (2.9%), and Japanese (0.1-0.5%) descent. For instance, 24% of northern Scandinavian [104, 105], 16% of Swedish [106-109], 14.3% of Belgium [74], 13% of German [110, 111], 12% of French [112-115], 11.2% of Romanian [116-121], 10.2% of Russian [122] populations express HLA-B*27 allele. HLA-B*27 allele is, overall, not frequent in Oriental populations, except for Taiwanese where this allele is highly frequent (15%).…”

Section: Resultsmentioning

confidence: 99%

Associations of HLA-A, HLA-B and HLA-C alleles frequency with prevalence of herpes simplex virus infections and diseases across global populations: Implication for the development of an universal CD8+ T-cell epitope-based vaccine

et al. 2014

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A significant portion of the world’s population is infected with herpes simplex virus type 1 and/or type 2 (HSV-1 and/or HSV-2), that cause a wide range of diseases including genital herpes, oro-facial herpes, and the potentially blinding ocular herpes. While the global prevalence and distribution of HSV-1 and HSV-2 infections cannot be exactly established, the general trends indicate that: (i) HSV-1 infections are much more prevalent globally than HSV-2; (ii) Over half billion people worldwide are infected with HSV-2; (iii) the sub-Saharan African populations account for a disproportionate burden of genital herpes infections and diseases; (iv) the dramatic differences in the prevalence of herpes infections between regions of the world appear to be associated with differences in the frequencies of human leukocyte antigen (HLA) alleles. The present report: (i) analyzes the prevalence of HSV-1 and HSV-2 infections across various regions of the world; (ii) analyzes potential associations of common HLA-A, HLA-B and HLA-C alleles with the prevalence of HSV-1 and HSV-2 infections in the Caucasoid, Oriental, Hispanic and Black major populations; and (iii) discusses how our recently developed HLA-A, HLA-B, and HLA-C transgenic/H-2 class I null mice will help validate HLA/herpes prevalence associations. Overall, high prevalence of herpes infection and disease appears to be associated with high frequency of HLA-A*24, HLA-B*27, HLA-B*53 and HLA-B*58 alleles. In contrast, low prevalence of herpes infection and disease appears to be associated with high frequency of HLA-B*44 allele. The finding will aid in developing a T-cell epitope-based universal herpes vaccine and immunotherapy.

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Section: Resultsmentioning

confidence: 99%

Associations of HLA-A, HLA-B and HLA-C alleles frequency with prevalence of herpes simplex virus infections and diseases across global populations: Implication for the development of an universal CD8+ T-cell epitope-based vaccine

et al. 2014

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“…The introduction of molecular typing in the 1990s shifted the focus to the detection of rare HLA alleles, or expression variants such null alleles. Over the years, testing of routine EPT samples has contributed to the identification of novel HLA alleles, including A*23:12 ( Hammond et al, 2006 ), A*11:15 ( Bendukidze et al, 2006 ), DQB1*02:01:04 ( Smillie et al, 2011 ), and A*03:162N ( Bengtsson et al, 2014 ).…”

Section: Educational Hla Typing Schemesmentioning

confidence: 99%

The history and evolution of HLA typing external proficiency testing schemes in UK NEQAS for H&I

De’Ath,

Rees,

Pritchard

2023

Front. Genet.

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The UK National External Quality Assessment Service (NEQAS) provide an external proficiency testing (EPT) service for clinical laboratories. UK NEQAS for Histocompatibility and Immunogenetics (H&I) has been providing EPT schemes for over 45 years and has grown during this time to provide 19 EPT schemes. Accurate human leucocyte antigen (HLA) typing is critical to support safe clinical services, including transplantation, therefore high quality, relevant EPT schemes are required as part of a laboratory’s quality assurance. This article reviews the development of the HLA typing EPT schemes, from the first HLA phenotyping scheme in 1975, via the first HLA genotyping scheme in 1992, through to the introduction in 2017 of HLA third field assessment results from next-generation sequencing technology. In addition, the introduction of EPT schemes to cover HLA associated diseases and pharmacogenetic reactions, including HLA-B27, HLA*B*57:01 and HLA-DQ for coeliac disease are discussed. The accuracy of laboratory EPT results for HLA phenotyping are >96% (2018–2022), HLA genotyping >99% (2020–2022), HLA-B27 testing >99% (2018–2022) and B*57:01 testing >99% (2017–2022). However, for HLA genotyping for coeliac disease 22%–46% of laboratories made errors in 2020–2022. On investigation, the high rate of unsatisfactory performance was attributed to laboratories lacking specific knowledge to interpret HLA genotyping results and accurately report HLA types for coeliac disease. A misleading commercial kit insert was also identified. The assessment of scheme results has uncovered several issues which have been addressed with the intention of educating participants and improving clinical services. The UK NEQAS for H&I EPT schemes have evolved over the past four decades to reflect changes in HLA typing technology, laboratory clinical practice and to cover post-analytical interpretative elements of HLA typing.

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Nomenclature for Factors of the HLA System, Update August 2006

Marsh

2006

Human Immunology

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HLA‐A*2312–a novel allele found during testing for the UK NEQAS for H&I DNA HLA‐typing scheme

Cited by 6 publications

References 5 publications

Associations of HLA-A, HLA-B and HLA-C alleles frequency with prevalence of herpes simplex virus infections and diseases across global populations: Implication for the development of an universal CD8+ T-cell epitope-based vaccine

Associations of HLA-A, HLA-B and HLA-C alleles frequency with prevalence of herpes simplex virus infections and diseases across global populations: Implication for the development of an universal CD8+ T-cell epitope-based vaccine

The history and evolution of HLA typing external proficiency testing schemes in UK NEQAS for H&I

Nomenclature for Factors of the HLA System, Update August 2006

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