HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 951 Southeast Asia Malays from Peninsular Malaysia

Tan, Lay Kim; Mohd-Farid, Baharin; Salsabil, Sulaiman; Heselynn, H.; Sulaiman, Wahinuddin; Lau, Ing-Soo; Gun, Suk-Chyn; Nor-Suhaila, Sharil; Eashwary, M; Said, Mohd Fuaad; Ainon, Mohd-Mokhtar; Rosman, Azmillah; Muhaini, Othman; Murad, Shahnaz; Too, Chun-Lai

doi:10.1016/j.humimm.2016.06.022

Cited by 14 publications

(21 citation statements)

References 6 publications

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“… d Data obtained from a report by Kongmaroeng et al ( 2015 ) (n = 170) . e Data obtained from a report by Tan et al ( 2016 ) (n = 951) . f Data obtained from a report by Yuliwulandari et al ( 2009 ) (n = 237) .…”

Section: Resultsmentioning

confidence: 99%

HLA Pharmacogenetic Markers of Drug Hypersensitivity in a Thai Population

et al. 2018

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Severe cutaneous adverse drug reactions (SCARs) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reactions with eosinophilia and systemic symptoms (DRESS) are potentially life-threatening cutaneous reactions caused by several drugs. Recently, a number of genes encoding for human antigen presenting proteins, HLA alleles, have been discovered as valid pharmacogenetic markers for prediction of these life-threatening reactions. This study was aimed to determine the distribution of HLA alleles including the HLA class I and class II genes in 183 unrelated individuals of a Thai population using high resolution HLA genotyping in order to obtain 2-field data (4-digit resolution) and compare the frequencies of the HLA alleles that have been proposed as markers of SCARs with other ethnics. Results revealed a high prevalence of pharmacogenetic markers of drug-induced SCARs e.g., B*13:01 for dapsone; B*15:02 for carbamazepine and oxcarbazepine; B*58:01, A*33:03 and C*03:02 for allopurinol; C*08:01, C*14:02 and DRB1*12:02 for co-trimoxazole. Whereas, low prevalence of pharmacogenetic markers of SCARs induced by abacavir, B*57:01 and phenytoin, B*56:02/B*56:04 were noticed. The allele frequencies of B*13:01, B*15:02, and B*58:01 observed in a Thai population were significantly higher than those reported in Japanese and Caucasian populations. Similar to those observed in other Southeast Asian populations, low frequencies of A*31:01 and B*57:01 alleles were noted in the study population. Based on the frequencies of HLA pharmacogenetic markers, Thai and other Southeast Asian populations may at higher risk of drug-induced SCARs compared with Caucasian population.

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Section: Resultsmentioning

confidence: 99%

HLA Pharmacogenetic Markers of Drug Hypersensitivity in a Thai Population

et al. 2018

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“…population-based case-control study. 23 The details of this study population have been described elsewhere. 23 25 The frequencies and ORs with 95% CIs of the HLA alleles were compared between the patients with SLE and normal control subjects using the χ 2 or Fisher's exact test, where appropriate.…”

Section: Discussionmentioning

confidence: 99%

“…23 The details of this study population have been described elsewhere. 23 25 The frequencies and ORs with 95% CIs of the HLA alleles were compared between the patients with SLE and normal control subjects using the χ 2 or Fisher's exact test, where appropriate. Adjustment for multiple comparisons were performed using the Bonferroni correction method.…”

Section: Discussionmentioning

confidence: 99%

“…We compared the HLA allelic frequency distributions and associations for risk of developing SLE using the HLA genotypes data obtained from the largest population-based normal controls with matched Malay ethnicity. 23 We also compared our data with the published significant studies to address the question how much of the identified HLA risk factors in multiple ethnic populations can be translated across the Malaysian Malay population and finally elucidate the generalisability of HLA risk factors in SLE populations of Caucasian, African and Asian descents.…”

Section: Key Messagesmentioning

confidence: 99%

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Human leucocyte antigens profiling in Malay female patients with systemic lupus erythematosus: are we the same or different?

et al. 2022

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ObjectiveSLE is a heterogeneous autoimmune disease, in terms of clinical presentation, incidence and severity across diverse ethnic populations. We investigated the human leucocyte antigens (HLA) profile (ie, HLA-A, HLA-B and HLA-C, HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1 and HLA-DPB1) in Malaysian Malay female patients with SLE and determined the generalisability of the published HLA risk factors across different ethnic populations globally including Malaysia.MethodsOne hundred Malay female patients with SLE were recruited between January 2016 and October 2017 from a nephrology clinic. All patients were genotyped for HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1 and HLA-DPB1 alleles using PCR sequence-specific oligonucleotides method on Luminex platform. A total of 951 HLA genotyped population-based Malay control subjects was used for association testing by means of OR with 95% CIs.ResultsOur findings convincingly validated common associations between HLA−A*11 (OR=1.65, p=3.36×10−3, corrected P (Pc)=4.03×10−2) and DQB1*05:01 (OR=1.56, p=2.02×10−2, Pc=non−significant) and SLE susceptibility in the Malay population. In contrast, DQB1*03:01 (OR=0.51, p=4.06×10−4, Pc=6.50×10−3) were associated with decreased risk of SLE in Malay population. Additionally, we also detected novel associations of susceptibility HLA genes (ie, HLA-B*38:02, DPA1*02:02, DPB1*14:01) and protective HLA genes (ie, DPA1*01:03). When comparing the current data with data from previously published studies from Caucasian, African and Asian populations, DRB1*15 alleles, DQB1*03:01 and DQA1*01:02 were corroborated as universal susceptibility and protective genes.ConclusionsThis study reveals multiple HLA alleles associated with susceptibility and protection against risk of developing SLE in Malay female population with renal disorders. In addition, the published data from different ethnic populations together with our study further support the notion that the genetic effects from association with DRB1*15:01/02, DQB1*03:01 and DQA1*01:02 alleles are generalised to multiple ethnic populations of Caucasian, African and Asian descents.

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“…Indeed, the Malay population exhibits wide diversity of HLA‐B*15 allotypes. Among these allotypes is HLA‐B*15:13, which acts as a KIR ligand virtue of possessing the Bw4 motif, and is common to many South‐East Asian populations 44,75,76 . Excluding the Bw4 motif, HLA‐B*15:13 is identical to the most frequent HLA‐B allotype in Malay, B*15:02, and therefore likely formed during a double‐crossover meiotic recombination event.…”

Section: Discussionmentioning

confidence: 99%

The combinatorial diversity of KIR and HLA class I allotypes in Peninsular Malaysia

et al. 2020

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We characterized HLA and KIR combinatorial diversity in Malay and Malay Chinese, identified substantial allelic and structural diversity of the KIR locus in both populations and discovered novel variations at each analysis level. The Malay are more diverse than Malay Chinese, likely representing a unique history that includes admixture with immigrating populations spanning several thousand years. Characterizing the Malay are KIR haplotypes with large structural variants present in 10% individuals, and the Malaysian Chinese, a low frequency of interactions of KIR2DL1 with C2+HLA‐C.

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HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 951 Southeast Asia Malays from Peninsular Malaysia

Cited by 14 publications

References 6 publications

HLA Pharmacogenetic Markers of Drug Hypersensitivity in a Thai Population

HLA Pharmacogenetic Markers of Drug Hypersensitivity in a Thai Population

Human leucocyte antigens profiling in Malay female patients with systemic lupus erythematosus: are we the same or different?

The combinatorial diversity of KIR and HLA class I allotypes in Peninsular Malaysia

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