HLA-A, -B, -DR haplotype frequencies in the Thai Stem Cell Donor Registry

Kupatawintu, Pawinee; Pheancharoen, S.; Srisuddee, Atthapol; Tanaka, Hidenori; Tadokoro, Kenji; Nathalang, Oytip

doi:10.1111/j.1399-0039.2010.01450.x

Cited by 18 publications

(15 citation statements)

References 18 publications

(27 reference statements)

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“…Although 3.3% of the healthy Thai population are HLA‐B27‐positive, a high prevalence of HLA‐B27‐positive ERA patients was shown in this study . This finding is in line with many Asian studies, especially in Chinese populations, which had high prevalence of spondyloarthropathy and HLA‐B27 .…”

Section: Discussionsupporting

confidence: 90%

A retrospective study on 158 Thai patients with juvenile idiopathic arthritis followed in a single center over a 15‐year period

et al. 2015

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Aim: To determine the outcomes of juvenile idiopathic arthritis (JIA) in Thai children.Methods: A retrospective cohort study. All JIA patients in a rheumatology clinic, Ramathibodi Hospital, between July 1997 and December 2012 were enrolled. The patient data were reviewed from medical records. At the most recent follow-up visit, patient outcomes were assessed in three aspects: disease status, functional outcomes and structural damage.Results: Of 168 patients, 158 (94.0%) were assessed in disease status and functional outcomes, with 114 patients (67.9%) assessed in three aspects over 4 years of disease. The most common JIA category was systemic JIA (SJIA) (33.8%), followed by enthesitis-related arthritis (ERA) (24.8%), oligoarthritis (18.5%), rheumatoid factor (RF)-negative polyarthritis (15.3%), RF-positive polyarthritis (7.6%) and one undifferentiated arthritis. SJIA had the highest remission rate due to early diagnosis and prompt treatment compared to other categories, whereas RF-positive polyarthritis carried the worst prognosis in three aspects, followed by ERA. Moreover, ERA patients had the highest failure rate in conventional therapy, half of whom had combined treatment with biologic agents and presence of human leukocyte antigen (HLA)-B27 was a predictor for biologic treatment in ERA patients. In addition, disease duration > 2 years or failure of conventional therapy was a predictor of structural bone damage.Conclusions: SJIA had the highest remission rate, whereas RF-positive polyarthritis had the worst outcome in three aspects. Prolonged disease duration or failure of conventional therapy was a predictor of structural bone damage, while HLA-B27 was a predictor for biologic treatment in ERA patients.

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Section: Discussionsupporting

confidence: 90%

A retrospective study on 158 Thai patients with juvenile idiopathic arthritis followed in a single center over a 15‐year period

et al. 2015

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“…Therefore, it is possible that HLA-B*46 was in a LD with a polymorphism locus of a HLA class II gene, which might influence professional antigen presenting cells through aberrant expression of HLA class II molecules on thyrocytes. However, in Asian populations, the HLA-B*46 are partly in LD of the DRB1*08:03, HLA-DRB1*09:01 and HLA-DRB1*14:03 alleles 47-49. It was also interesting to find that DRB1*08:03, HLA-DRB1*09:01 and HLA-DRB1*14:03 were associated with GD in Asian populations 14, 20, 22, 50.…”

Section: Discussionmentioning

confidence: 94%

Association between HLA-B*46 Allele and Graves Disease in Asian Populations: A Meta-Analysis

Li¹,

Yao²,

Yang³

et al. 2013

Int. J. Med. Sci.

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Graves' disease (GD) is a leading cause of hyperthyroidism, which affects 1.0-1.6% of the general population. Previous studies reported a higher GD prevalence in Asian populations compared to Caucasian populations. The etiology of GD involves complex interactions between predisposing genes and environmental triggers. Genetic studies have shown that the human leukocyte antigen (HLA) is an important candidate genetic region associated with GD in Asian populations. However, the results were inconsistent and inconclusive. Here, we performed a meta-analysis to evaluate the role of the HLA-B*46 allele in GD in Asian populations. A total of 14 case-controlled studies on the association of the HLA-B*46 allele in 1743 GD patients and 5689 controls were included. Our results showed a trend toward an increased risk of GD in HLA-B*46-positive subjects compared to those HLA-B*46-negative (OR = 2.48; 95% CI = 1.96-3.13, P < 0.01). However, there were some limitations to the current meta-analysis, such as heterogeneity (Pheterogeneity < 0.01 and I2 = 68.0%) or the different typing methods (serological and genotyping methods). The meta-analysis indicated that the HLA-B*46 allele is a risk factor for GD in Asian populations. Future studies on the role of the HLA-B*46 allele in GD should consider complications such as periodic paralysis, ophthalmopathy and recurrence.

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“…The phylogenetic tree is constructed with HLA-A, -B and -DRB1 allele frequencies presented in Table 2 and the published data for the northern Han Chinese from the Shaanxi region [10], southern Han Chinese from the Guangdong region [11], Koreans from Seoul Korea [12], Minnan ethnic group from Taiwan [13], Thai people in Thailand [14] and Japanese in Japan [15]. Liaoning is a province in the northeastern part of China as shown in the map of China (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

An Analysis of HLA-A, -B, and -DRB1 Allele and Haplotype Frequencies of 21,918 Residents Living in Liaoning, China

Li¹,

Zhang²,

Chen³

et al. 2014

PLoS ONE

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HLA-A, -B and -DRB1 allele frequencies and their haplotype frequencies in 21,918 Chinese residents living in Liaoning Province, who were registered as volunteer donors of China Marrow Donor Registry, were investigated. They are composed of 93.37% Han Chinese, 5.1% Manchus, 0.57% Mongols, 0.46% Hui persons, 0.29% Koreans and 0.14% Xibe ethnic group. In total eighteen different HLA-A alleles, forty-eight different HLA-B alleles and fourteen different HLA-DRB1 alleles have been identified. Their frequencies are in agreement with the Hardy-Weinberg equilibrium. For Han Chinese in Liaoning, 1,534 different HLA-A-B-DRB1 haplotypes were identified, with a frequency of higher than 0.01%. A*30-B*13-DRB1*07, A*02-B*46-DRB1*09 and A*02-B*13-DRB1*12 are the most frequent haplotypes among Liaoning Han. While Liaoning Han, Liaoning Manchu, Liaoning Mongol, Liaoning Hui and Liaoning Korean share the northern Han characteristic haplotypes, all minority ethnic groups with the exception of Liaoning Manchu have developed their own unique HLA profiles. This dataset characterizes the HLA allele and haplotype frequencies in the Liaoning area and suggests that it is different from those in other parts of China and ethnic groups, which implicates transplant donor searching strategies and studies on population genetics.

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HLA-A, -B, -DR haplotype frequencies in the Thai Stem Cell Donor Registry

Cited by 18 publications

References 18 publications

A retrospective study on 158 Thai patients with juvenile idiopathic arthritis followed in a single center over a 15‐year period

A retrospective study on 158 Thai patients with juvenile idiopathic arthritis followed in a single center over a 15‐year period

Association between HLA-B*46 Allele and Graves Disease in Asian Populations: A Meta-Analysis

An Analysis of HLA-A, -B, and -DRB1 Allele and Haplotype Frequencies of 21,918 Residents Living in Liaoning, China

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