HLA allele and haplotype frequencies in Algerians: Relatedness to Spaniards and Basques

Arnaiz-Villena, Antonio; Benmamar, Djamal; Díaz-Campos, Nieves; Gómez-Casado, Eduardo; Álvarez, Miguel A.; Varela, Pilar; Martı́nez-Laso, Jorge

doi:10.1016/0198-8859(96)84974-3

Cited by 46 publications

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“…Other studies with the Y-chromosome, 38,42 and also with other genetic markers, have detected this Northwest African influence in northern Iberia. For instance, Basque and Berber Algerians share some infrequent HLA haplotypes, 20 and Basques, but also Cantabrians and French from the Pyrenees, share African-specific GM immunoglobulin haplotypes. 54 Moreover, haplotypes belonging to the Northwest African U6 mtDNA cluster have been found in Galicia and Northern Portugal, but are rare or absent in Southern areas.…”

Section: Resultsmentioning

confidence: 99%

Reduced genetic structure of the Iberian peninsula revealed by Y-chromosome analysis: implications for population demography

et al. 2004

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Europe has been influenced by both intra-and intercontinental migrations. Since the Iberian peninsula was a refuge during the Last Glacial Maximum, demographic factors associated with contraction, isolation, subsequent expansion and gene flow episodes have contributed complexity to its population history. In this work, we analysed 26 Y-chromosome biallelic markers in 568 chromosomes from 11 different Iberian population groups and compared them to published data on the Basques and Catalans to gain insight into the paternal gene pool of these populations and find out to what extent major demographic processes account for their genetic structure. Our results reveal a reduced, although geographically correlated, Y-chromosomal interpopulation variance (1.2%), which points to a limited heterogeneity in the region. Coincidentally, spatial analysis of genetic distances points to a focal distribution of Y-chromosome haplogroups in this area. These results indicate that neither old or recent Levantine expansions nor North African contacts have influenced the current Iberian Y-chromosome diversity so that geographical patterns can be identified.

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Section: Resultsmentioning

confidence: 99%

Reduced genetic structure of the Iberian peninsula revealed by Y-chromosome analysis: implications for population demography

et al. 2004

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“…The compilation of classical genetic markers (Bosch et al 1997;Simoni et al 1999) has shown a clear genetic differentiation between the northern and southern coasts, attributed to independent parallel expansions along the two shores followed by little gene flow across the Mediterranean. Nevertheless, there is some contradictory data, based on HLA polymorphisms, on the degree of genetic relationship between both coasts in West Mediterranean populations (Arnaiz-Villena et al 1995;Comas et al 1998). Analyses of autosomal STRs and Alu insertion polymorphisms confirmed the genetic difference between both groups of populations, also detecting some Sub-Saharan genetic flow into NW African populations.…”

Section: Introductionmentioning

confidence: 99%

Joining the Pillars of Hercules: mtDNA Sequences Show Multidirectional Gene Flow in the Western Mediterranean

Plaza

Calafell

Helal

et al. 2003

Annals of Human Genetics

122

115

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SummaryPhylogenetic analysis of mitochondrial DNA (mtDNA) performed in Western Mediterranean populations has shown that both shores share a common set of mtDNA haplogroups already found in Europe and the Middle East. Principal co-ordinates of genetic distances and principal components analyses based on the haplotype frequencies show that the main genetic difference is attributed to the higher frequency of sub-Saharan L haplogroups in NW Africa, showing some gene flow across the Sahara desert, with a major impact in the southern populations of NW Africa. The AMOVA demonstrates that SW European populations are highly homogeneous whereas NW African populations display a more heterogeneous genetic pattern, due to an east-west differentiation as a result of gene flow coming from the East. Despite the shared haplogroups found in both areas, the European V and the NW African U6 haplogroups reveal the traces of the Mediterranean Sea permeability to female migrations, and allowed for determination and quantification of the genetic contribution of both shores to the genetic landscape of the geographic area.Comparison of mtDNA data with autosomal markers and Y-chromosome lineages, analysed in the same populations, shows a congruent pattern, although female-mediated gene flow seems to have been more intense than male-mediated gene flow.

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“…Twenty different HLA-DRB1 and eleven different HLA-DQB1 alleles were found in Tenerife Island sample ( NJ relatedness dendrogram based on HLA-DRB1 allele frequencies (Fig.4) et al, 2004), Souss-Berber (Izaabel et al,, 1978), Moroccan (Gomez-Casado et al, 2000) and Algerians (Arnaiz-Villena et al, 1995). (Imanishi et al, 1991c), Wales (Darke et al, 1998) and Northwest England (Alfirevic et al, 2012).…”

Section: Hla Allele Frequencies Found In Tenerife Population: Comparimentioning

confidence: 99%

Origin of Ancient Canary Islanders Guanches: presence of Atlantic/Iberian HLA and Y chromosome genes and Ancient Iberian language

Arnaiz‐Villena¹,

Muñiz²,

Campos³

et al. 2015

Int.J.Mod.Anthrop

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HLA allele and haplotype frequencies in Algerians: Relatedness to Spaniards and Basques

Cited by 46 publications

References 0 publications

Reduced genetic structure of the Iberian peninsula revealed by Y-chromosome analysis: implications for population demography

Reduced genetic structure of the Iberian peninsula revealed by Y-chromosome analysis: implications for population demography

Joining the Pillars of Hercules: mtDNA Sequences Show Multidirectional Gene Flow in the Western Mediterranean

Origin of Ancient Canary Islanders Guanches: presence of Atlantic/Iberian HLA and Y chromosome genes and Ancient Iberian language

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