No abstract

HLA genes (class I and II) have been studied in a Kurd population from Iran (North West towns of Saqqez and Baneh, close to Irak border). Kurds speak an Iranian language. HLA Kurd profile has been compared with those of Central Asians, Siberians, Mediterraneans and other worldwide populations; a total of 7746 chromosomes were used for computer comparisons. Both Neighbor-joining and correspondence genetic analyses place Kurds in the Mediterranean population cluster, close to Iranians, Europeans and Caucasus populations (Svan and Georgian). New extended HLA haplotypes are described, being A*02:01-B*35:01-DRB1*01:01-DQB1*05:01 and A*24:02-B*18:09-DRB1*11:01- DQB1*03:01 the most frequent ones; other Kurd extended haplotypes are also found in Azeris and Palestinians. This research work may be useful for: 1) future Iranian Kurds transplantation regional programs, 2) HLA pharmacogenomics in order to practise a preventive Medicine and drug side effects, and 3) Epidemiology of HLA-associated diseases in Kurds.

Background: HLA-G molecules are immunosuppressive and avoid fetal rejection by giving negative signals to maternal immune system from fetal trophoblast cell surface. HLA-G genes have been associated to different pathologies: Spontaneous abortions, autoimmunity, tumor progression, transplant rejection and infection. In addition, different World populations show remarkable different HLA-G allele frequencies in the allele that does not produce a full HLA-G molecule (HLA-G*05N); this allele is almost absent in studied Amerindians. Objectives: The aim is to study HLA-A.-B,-DRB1 and –G alleles and extended haplotypes in Amerindians for the first time. This may be useful to asses HLA-G epidemiology, association to disease and Preventive Medicine in Amerindians. Methods: HLA-A,-B and -DRB1 have been typed by using standard automatic protocols. HLA-G alleles have been detected by direct HLA-G exon 2, exon 3 and exon 4 DNA sequencing. Computer calculations have been done by specific standard methods. Results: HLA-A,-B,-DRB1 and –G extended haplotypes have been calculated in Amerindians for the first time. Also, their HLA-G frequencies have been compared with worldwide populations. Conclusion: Low frequencies of null HLA-G*01:05N allele are found in Amerindians. The extended haplotypes with this allele bear other typical Amerindian HLA-DRB1 alleles and its origin is discussed. HLA-G allele frequency profile is closer to that of Europeans than to that of Far East Asians. Our findings are useful to Preventive Medicine and Epidemiology associated to Fertility and HLA-G associated pathology and transplantation.

Americas peopling has recently been explained based only on genetic data. While different First America inhabitants' ethnic groups, Amerindians, Na-Dene speakers, Aleuts and Eskimo there exist, there is no either genetic, cultural or anthropological homogeneity within these groups. In the present work, we have particularly addressed the relatedness of First America Inhabitants with Pacific Islanders by using autosomal genetic markers: the HLA alleles. HLA is the most polymorphic human genetic system accounting for 9,438 alleles; this is most useful for comparing populations relatedness. Ethnic groups of Pacific Islanders and First America Inhabitants have been used. A genealogic study and also a frequency comparison study by using HLA alleles and haplotypes have been carried out. Our conclusions are: 1-Aleuts seem to be a genetic and linguistic separate group which may be related to northern European Lapps, both of them originated in southern Siberia Baikal Lake area. This work partial results were given at a lecture by Antonio Arnaiz-Villena at The Royal Society (London)-June 9th 2011 "Origin of Amerindians and their genetic relatedness with Asian and Pacific islanders " (https://royalsociety.org/events/2011/plagues-pathogens-selection/) -Sesion 3.

Abstract-Atlantic Europe populations were analyzed with HLA genes in order to establish their relationship among themselves and with other populations. Standard genetic and statistical software analyses were used. Celtic populations (British Isles and French Bretons) have genetically been found close together: