HLA and Insulin-Dependent Diabetes Mellitus in Koreans

Abstract

Specific allelic associations vary among ethnic groups. We studied the distribution of HLA-A, -B, -C and -DR antigens in 41 patients with insulin-dependent diabetes mellitus (IDDM) and 280 unaffected persons in Korea. HLA typing was performed by the standard microlymphocytotoxicity test using antisera supplied by the Third Asia-Oceania Histocompatibility Workshop Conference (3rd AOHWC, 1986).There was no association between HLA-A, -B, or -C and IDDM. However, the frequencies of HLA-DR3 and HLA-DR4 were increased in the patients as compared with the controls (19.5% vs 4.3%, RR 5.4, corrected p < 0.005 for DR3 and 61.0% vs 36.4%, RR 2.7, corrected p < 0.05 for DR4). Also a decreased frequency of HLA-DR2 was found in the patients with IDDM (9.8% vs 32.1%, RR 0.3, corrected p < 0.05).These results emphasize the differences in HLA-IDDM associations among different ethnic groups.

RFLP Analysis of HLA-DRβ and -DQβ Genes in the Korean Patients with Insulin-Dependent Diabetes Mellitus

“…We have previously suggested the possible protective role of DRw6 in Korean IDDM patients using serotyping of HLA-DR antigens 3 ) . Interestingly, we also found a decreased frequency of the 12 kb/DR β /Taq I fragment within the DRw6 specificity in the present study.…”

“…All subjects were serologically DR-typed and studied by RFLP analysis using class II HLA gene probes. DR-serotyping was by a standard microlym-phocytotoxicity method using antisera supplied for the Third Asia-Oceania Histocompatibility Workshop Conferences in 1986, as previously described 3 ) . DR antigens 1,2,3,4,5,w6,7,w8,w9 and w10 were determined in all subjects tested.…”

A Global Perspective of Latent Autoimmune Diabetes in Adults

“…and HLA-DR4 play a consistent role across multiple ethnicities [40][41][42][43][44][45]. Moreover, there is a greater increase in risk for patients with DR3/DR4 heterozygosity than those with only the DR3 haplotype.…”