HLA and peptic ulcer

O'Brien, Brian; Thomson, A. B. R.; Dossetor, John B.

doi:10.1007/bf01296547

Cited by 16 publications

(4 citation statements)

References 4 publications

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“…They also found HLA Bw35, and B5 showed posi tive-linkage disequilibrium, thus explaining the differences between their findings and those of Rotter et al [15]. In a study of 92 white Canadian GU and DU patients, O'Brien et al [11] found no association with HLA antigens with the A or B series; how ever, HLA Bw49 was not studied. These conflicting findings are not readily reconciled.…”

Section: Discussionmentioning

confidence: 40%

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HLA Antigens and Peptic Ulcer Disease

Kang¹,

Doran²,

Crampton³

et al. 1983

Digestion

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The aim of this study was to investigate the association of HLA antigens with chronic duodenal and gastric ulcer. 104 patients with chronic peptic ulcer, 52 with duodenal ulcer, and 52 with gastric ulcer were studied, and HLA antigens of the A, B and DR series were sought using the microlymphocytotoxicity test. In duodenal-ulcer patients, no significant differences were observed. In the gastric-ulcer group, Bw49 was increased in both sexes, with an adjusted odds ratio of 10.2. However, when corrected for the number of comparisons made, this difference failed to reach statistical significance. It is concluded that if HLA antigens make any contribution to the aetiology of ulcer disease, this contribution is small and the proportion of cases of gastric ulcer that can be explained by the presence of HLA antigen Bw49 is less than 10%.

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Section: Discussionmentioning

confidence: 40%

“…Some data also exist on the association of HLA antigens and duodenal ulcer (DU) [5,7,11,14,18]. The aim of the present study was to define the association of chronic ulcer, both gastric (GU) and DU, with HLA anti gens of the A, B and DR scries.…”

mentioning

confidence: 99%

HLA Antigens and Peptic Ulcer Disease

Kang¹,

Doran²,

Crampton³

et al. 1983

Digestion

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“…A large Russian study also found associations of gastric ulcer with HLA‐B15, ‐B35, and ‐Cw4, whereas HLA‐A3 was found to be protective [69]. Two other studies, however, have failed to detect any association with HLA antigens, possibly because of the differing ethnic groups studied [71,72].…”

Section: Specific Host Factors Associated With Clinical Disease Outcomementioning

confidence: 99%

Host Determinants of Helicobacter pylori Infection and Its Clinical Outcome

1999

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Greater than one-half of the world's population harbors Helicobacter pylori. The majority of infected individuals, however, remain asymptomatic, with only 10% to 20% developing diseases, including peptic ulcer disease, gastric cancer, and gastric mucosa-associated lymphoid tissue lymphoma. This article reviews host factors that may predispose an individual to both the acquisition of H. pylori infection and subsequent clinical outcome. Individuals with specific blood group antigens and human leukocyte antigen genotypes may be more susceptible to H. pylori infection. Additional factors, such as the age of acquisition, the host immune response, the site of infection, acid secretion, and interactions with nonhost factors (including bacterial virulence factors and environmental influences) may play a role in determining clinical outcome. Further investigation is required to clarify the mechanisms by which these interactions occur and, more critically, to determine their relative importance. This knowledge will enable the identification of individuals at risk of developing clinical disease with H. pylori infection.

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“…In an attempt to find other genetic factors playing a role in duodenal ulcer disease, some studies have been done o n the frequencies of H L A antigens in patients with a duodenal ulcer. Associations with IlLA-BS, HLA-B12, and HLA-Bw3S have been described (Rotter et al 1977, Ellis & Woodrow 1979, Gough et al 1982), but in two other studies no association was found (Heschl & Tilz 1976, O'Brien et al 1979. To obtain more information on this point, we investigated HLA antigens in Dutch 1111 patients.…”

mentioning

confidence: 90%

HLA and duodenal ulcer in The Netherlands

Goedhard¹,

Biemond²,

Peña³

et al. 1983

Tissue Antigens

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Eighty-one Dutch patients with a duodenal ulcer (DU) were tested with respect to 24 H1.A antigens. lhcre was no significant difference in the distribution of HLA antigens between the DU patients and the controls. Howcvcr, none of the 22 patients younger than thirty years at the onset of symptoms had HLA-Bw35, whereas among the 59 patients aged betwe-en thirty and eighty at the onset of symptoms, twelve had this antigen.

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HLA and peptic ulcer

Cited by 16 publications

References 4 publications

HLA Antigens and Peptic Ulcer Disease

HLA Antigens and Peptic Ulcer Disease

Host Determinants of Helicobacter pylori Infection and Its Clinical Outcome

HLA and duodenal ulcer in The Netherlands

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