HLA and Thyrotoxicosis (Graves' Disease) in Chinese

Abstract

HLA locus A and B typing was performed on 86 Chinese thyrotoxicosis (Graves' Disease) patients and 238 normal Chinese subjects. The frequency of HLA-Bw46 (Sin 2) was found to be significantly higher among the patients than controls (x2 = 26.15, corrected P less than .003, relative risk = 3.74). The risk associated with Bw46 was reflected in the Bw46 heterozygotes. The relative risks of the joint occurrence of Bw46/B40 and Bw46/B13 were 8.74 and 5.88 respectively.

Identification of CD8+ T-Cell Epitopes Specific for Immediate-Early Transactivator Rta of Epstein-Barr Virus

“…Besides NPC, B4601 has also been shown to be associated with two autoimmune diseases, myasthenia gravis [30] and Graves disease [31,32], in the Chinese. B5801 is associated with NPC and also with insulin-dependent diabetes mellitus (IDDM) in Singaporean Chinese [33], suggesting defective immune responses associated with these two HLA class I molecules.…”

Association of HLA Alleles with Autoimmune Thyroid Disease in Korean Children

“…Similarly, Wang et al [32] and Hawkins et al [33,34] also reported an association of HLA-B46 with HD in Shanghai Chinese, Southern Chinese and Hong Kong Chinese. Chan et al [35] also reported that there is an increased allele frequency of the HLA-B46 allele in Chinese GD patients. HLAs of the Korean population are known to be similar to those of the Japanese population [36].…”

Immune Mechanisms In Graves' Disease

“…The best example of this type of association is the increased incidence of HLADRw3, a Class II antigen, in Caucasian Graves' disease patients (316). This is a well documented finding with up to 60% of Graves' patients being reported to have this antigen as compared to 11% of the control populations (324)(325)(326)(327)(328)(329)(330)(331)(332)(333)(334). One might postulate that owing to their pivotal role in antigen presentation, a particular Class II antigen might facilitate the development or propagation of an autoimmune respone to thyroid antigens.…”

“…This study (221) has the distinct advantage of apparently being prospective where each patient underwent an identical protocol, but it would have been informative if TSI as well as TBII levels were measured. Although other studies have observed an association between the presence of HLA B8 or DRw3 antigens and Graves' disease (316)(317)(318)(319)(320)(321)(322)(323)(324)(325)(326)(327)(328)(329)(330)(331)(332)(333)(334), some investigators have not noted the propensity for these patients to relapse (316,327,328,334). Allannic et al (329) studied 94 Graves' disease patients and found that 47.8% had B8 (healthy controls 21.5%); 53.2% had DR3 (healthy controls 21.2%); and 42.5% had combined B8 and DR3 antigens (healthy controls 13.3%).…”