HLA Antigens and Aginga

Morellini, M; Trabace, S; Lulli, Patrizia; Cappellacci, Sandra; Brioli, Gloria; Orru, D; Pennesi, Giuseppina; Monti, Daniela; Cossarizza, Andrea; Lambert-Gardini, S.; Sansoni, Paolo; Franceschi, Claudio

doi:10.1111/j.1749-6632.1992.tb38715.x

Cited by 14 publications

(9 citation statements)

References 3 publications

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“…Only a very few studies have considered a possible relationship between phenotypic combinations and longevity though antigen combinations have been related to autoimmune and other disease entities 18 . Morellini et al 22 noted a significant increase in the B44 DRw6 combination in their group of elderly females compared with young females, but the frequencies of the antigen combination were rather low to be statistically compared. One point to emerge from this study was the finding that the phenotypic combination A1B8Cw7DR3 was more common in nonagenarian men compared with young males (OR = 3.1) and also compared with elderly females (OR = 1.5).…”

Section: Discussionmentioning

confidence: 99%

“…By contrast, the present study using the more reliable RFLP method showed no differences in HLA-DR antigens, including DR3, in Caucasians between the nonagenarian and younger groups. It is of interest to note that both the HLA-DR3 antigen in CaucasianslNegroid population and the HLA-DRw9 and HLA DR1 in Oriental/japanese are associated with immune hyperactivity and clinical manifestation of autoimmune diseases.l" Only a very few studies have considered a possible relationship between phenotypic combinations and longevity though antigen combinations have been related to autoimmune and other disease entities.l" Morellini et al 22 noted a significant increase in the B44 DRw6 combination in their group of elderly females compared with young females, but the frequencies of the antigen combination were rather low to be statistically compared. One point to emerge from this study was the finding that the phenotypic combination AIB8Cw7DR3 was more common in nonagenarian men compared with young males (OR = 3.1) and also compared with elderly females (OR = 1.5).…”

Section: Comparison Analysismentioning

confidence: 99%

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Is the Phenotypic Combination A1B8Cw7DR3 a Marker for Male Longevity?

Rea¹,

Middleton²

1994

J American Geriatrics Society

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Section: Discussionmentioning

confidence: 99%

Section: Comparison Analysismentioning

confidence: 99%

Is the Phenotypic Combination A1B8Cw7DR3 a Marker for Male Longevity?

Rea¹,

Middleton²

1994

J American Geriatrics Society

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“…In most cases, they have been free of cancer, dementia, diabetes, cardiovascular diseases, and cataracts. Moreover, to reach such an advanced age, they should be equipped with well-preserved and efficient immuno-and defense mechanisms and optimal combinations of an appropriate lifestyle and genetic background (68,125). Thus, the study of centenarians and particularly of those in optimal condition is not only of broad biological and medical interest but can help in identifying genes, cells, and immune strategies that prevent age-related diseases.…”

Section: Are Centenarians Exceptional Individuals?mentioning

confidence: 99%

Cytometric analysis of immunosenescence

Cossarizza¹,

Ortolani²,

Monti³

et al. 1997

Cytometry

133

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We have been studying the immune system of healthy centenarians for many years, and they provide the best example of successful aging. They are people who have escaped major age‐related diseases and reached the extreme limit of human life in good clinical condition. In most cases, histories of centenarians reveal them to be free of cancer, dementia, diabetes, cardiovascular diseases, and cataracts. Moreover, in order to reach such an advanced age, they should be equipped with well preserved and efficient immuno‐ and defense mechanisms, and optimal combinations of an appropriate lifestyle and genetic background. Using this approach, several paradoxes emerged as far as the immune system of centenarians is concerned, regarding: (i) humoral immunity (increase in plasma immunoglobulins and nonorgan‐specific autoantibodies, decrease in B cell number and lack of organ‐specific autoantibodies); (ii) cellular immunity (well preserved number of “virgin” T cells, a relatively intact T cell repertoire despite a thymus involuting since puberty, increased number of cells with markers of NK activity); (iii) decreased peripheral blood lymphocyte tendency to programmed cell death, associated with a well preserved mitochondria functionality and intracellular bcl‐2 levels. An age‐related increase in the levels of adhesion molecule present on lymphocyte plasma‐membrane, accompanied by a complex reshaping of the cytokine network, must be added to this scenario. All our data fit the hypothesis that a complex, unpredicted remodeling of the immune system occurs with age. In the present review it is underlined how flow cytometry has been used to study most of the above mentioned aspects of immunosenescence, and to establish new age‐related reference values. Cytometry 27:297–313, 1997. © 1997 Wiley‐Liss, Inc.

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“…A decrease in frequencies is described for A1, 10 B40, 10 B60 (a split of B40), 9 and DR9 8 . It is also suggested that increased frequencies of Cw1 and the phenotypic combinations A1B8Cw7DR3 11 , 12 and B44DR6 13 are associated with advanced age. Other investigators do not report any differences in antigen frequency 14 .…”

mentioning

confidence: 93%