HLA Antigens In Hodgkin's Disease of Very Long Survival

Hornmark-Stenstam, B; Landberg, T.; Löw, Bengt

doi:10.3109/02841867809127930

Cited by 6 publications

(5 citation statements)

References 6 publications

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“…Interestingly, some of the earlier studies performed at a time with much higher mortality from HL also observed a survival advantage in association with particular HLA class I types . An increased frequency of HLA‐A28 and A8 was observed in HL patients with greater than 15 and 5 years survival, respectively . Although HLA‐A1 was associated with increased disease risk, it was also associated with improved survival and treatment response .…”

Section: Early Hla Association Studies In Hlmentioning

confidence: 92%

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Human leukocyte antigens and genetic susceptibility to lymphoma

McAulay

Jarrett

2015

Tissue Antigens

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Familial aggregation, coupled with ethnic variation in incidence, suggests that inherited susceptibility plays a role in the development of lymphoma, and the search for genetic risk factors has highlighted the contribution of the human leukocyte antigen (HLA) complex. In a landmark study published almost 50 years ago, Hodgkin lymphoma (HL) was the first disease to be associated with HLA variation. It is now clear that Epstein‐Barr virus (EBV)‐positive and ‐negative HL are strongly associated with specific HLA polymorphisms but these differ by EBV status of the tumours. HLA class I alleles are consistently associated with EBV‐positive HL while a polymorphism in HLA class II is the strongest predictor of risk of EBV‐negative HL. Recent investigations, particularly genome‐wide association studies (GWAS), have also revealed associations between HLA and common types of non‐Hodgkin lymphoma (NHL). Follicular lymphoma is strongly associated with two distinct haplotypes in HLA class II whereas diffuse large B‐cell lymphoma is most strongly associated with HLA‐B*08. Although chronic lymphocytic leukaemia is associated with variation in HLA class II, the strongest signals in GWAS are from non‐HLA polymorphisms, suggesting that inherited susceptibility is explained by co‐inheritance of multiple low risk variants. Associations between B‐cell derived lymphoma and HLA variation suggest that antigen presentation, or lack of, plays an important role in disease pathogenesis but the precise mechanisms have yet to be elucidated.

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Section: Early Hla Association Studies In Hlmentioning

confidence: 92%

“…Subsequent investigations using serological typing methods demonstrated an increased frequency of HLA‐B5, B8, B18 and HLA‐A1 subtypes in HL patients (Table ) . The strongest association was shown for HLA‐A1 with a sixfold increase in risk of developing HL .…”

Section: Early Hla Association Studies In Hlmentioning

confidence: 96%

Human leukocyte antigens and genetic susceptibility to lymphoma

McAulay

Jarrett

2015

Tissue Antigens

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“…This revealed an association of HLA-A28 with malignancy (11 %, p=0.006). Interestingly, this class I HLA type has been associated with certain types of malignancy, like osteosarcoma [45], germ cell tumors [46], and survivors of Hodgkin's disease [47]. This could signify a genetic association between myositis and malignancy.…”

Section: Risk Factors For Malignancy In Patients With Iimmentioning

confidence: 99%

Idiopathic Inflammatory Myopathies and Malignancy: a Comprehensive Review

Tiniakou

Mammen

2015

Clinic Rev Allerg Immunol

115

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The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of autoimmune diseases (collectively known as myositis) affecting the skeletal muscles as well as other organ systems such as skin, lungs, and joints. The primary forms of myositis include polymyositis (PM), dermatomyositis (PM), and immune-mediated necrotizing myopathy (IMNM). Patients with these diseases experience progressive proximal muscle weakness, have characteristic muscle biopsy findings, and produce autoantibodies that are associated with unique clinical features. One distinguishing feature of these patients is that they are also known to have an increased risk of cancer. Since the first description of the association in 1916, it has been extensively reported in the medical literature. However, there have been significant variations between the different studies with regard to the degree of cancer risk in patients with IIM. These discrepancies can, in part, be attributed to differences in the definition of malignancy-associated myositis used in different studies. In recent years, significant advances have been made in defining specific features of IIM that are associated with the development of malignancy. One of these has been myositis-specific antibodies (MSAs), which are linked to distinct clinical phenotypes and categorize patients into groups with more homogeneous features. Indeed, patients with certain MSAs seem to be at particularly increased risk of malignancy. This review attempts a systematic evaluation of research regarding the association between malignancy and myositis.

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“…Several reports demonstrated an increased frequency of HL class I alleles HLA‐B5 (43, 44), HLA‐B8 (43, 45), HLA‐B18 (31, 46), and HLA‐A1 (47, 48) in HL patients in the 1970s and 1980s. According to Hafez et al ., individuals carrying the HLA‐A1 antigen have a sixfold increased risk of developing HL (48).…”

Section: Hla Associations In Hodgkin's Lymphomamentioning

confidence: 99%

“…In a group of 40 patients, Hornmark‐Stenstam et al . observed an increased frequency of HLA‐A28 among the 10 patients with a very long disease free survival (46). Similarly, a significantly poorer survival was observed in patients with positive Aw19 serology.…”

Section: Hla Associations In Hodgkin's Lymphomamentioning

confidence: 99%

Genetic susceptibility to Hodgkin's lymphoma associated with the human leukocyte antigen region

Diepstra

Niens

Meerman

et al. 2005

European J of Haematology

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Based on the presence of an abundant inflammatory infiltrate, expression of a broad spectrum of cytokines and the professional antigen presenting phenotype of Hodgkin Reed‐Sternberg cells it can be anticipated that immunological mechanisms play a major role in the pathogenesis of Hodgkin's lymphoma (HL). Genetic susceptibility to HL probably relates to functionality of the immune system and the large number of associations with the human leukocyte antigen (HLA) region in family and population‐based studies supports this relation. In Epstein–Barr virus (EBV) positive HL cases, which usually demonstrate HLA class I expression, HRS cells should be able to present EBV derived antigenic peptides and trigger the immune system. This process depends on the affinity of the HLA binding groove for binding immunogenic peptides and thus on the HLA alleles. It can be anticipated that certain combinations of alleles predispose to or protect from the development of EBV positive HL. In EBV negative HL cases other antigenic peptides, related to malignant transformation, in combination with other HLA alleles may be involved. In addition, differential attraction and activation of inflammatory cells may influence HL subtype. In this article, possible roles of HLA in HL pathogenesis are explored and genetic associations of HLA with HL are reviewed and commented on.

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HLA Antigens In Hodgkin's Disease of Very Long Survival

Cited by 6 publications

References 6 publications

Human leukocyte antigens and genetic susceptibility to lymphoma

Human leukocyte antigens and genetic susceptibility to lymphoma

Idiopathic Inflammatory Myopathies and Malignancy: a Comprehensive Review

Genetic susceptibility to Hodgkin's lymphoma associated with the human leukocyte antigen region

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