HLA antigens in leprosy patients

Bale, Uma M.; Mehta, M. M.; Contractor, Nafisa M.; Bhatia, H. M.; Koticha, K K

doi:10.1111/j.1399-0039.1982.tb00336.x

Cited by 13 publications

(3 citation statements)

References 4 publications

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“…HLA-Aw33 was reported, in the Second Asia Oceania Histocompatibility Workshop, to be increased in Chinese patients with lepromatous leprosy, and HLA-A11 was reported to be increased in Japanese patients with non-lepromatous leprosy (Serjeantson et al 1983). Although no significant difference was observed for HLA-B locus alleles in this analysis, several studies have reported significant differences for HLA-B antigens in other populations (Thorsby et al 1973, Kreisler et al 1974, Smith et al 1975, Dasgupta et al 1975, Takata et al 1978, Chan et al 1979, Bale et al 1982.…”

Section: Discussioncontrasting

confidence: 58%

HLA and leprosy in Koreans

et al. 1987

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HLA antigens in 157 unrelated Koreans with leprosy have been identified and compared with 162 healthy Korean controls. The patient group consisted of 124 with lepromatous leprosy and 33 with tuberculoid leprosy. Although no significant differences were detected between the two patient groups, several antigens were found to be increased in the combined patient group compared to healthy controls. Two Class I antigens were increased: HLA-All (22% vs 12%) and Aw33 (27% vs 14%). Four Class I1 antigens were increased: HLA-DR1 (16% vs 7%), DR2 (39% vs 21%). DRw9 (14% vs 6%) and DQwl (74% vs 55%). HLA-DR4 (28% vs a%), DRw53 (46% vs 69%) and DQw3 (500/, vs 75%) in contrast were significantly decreased in patients. Interaction of DRI, DR2, DRw9 and DQwl as risk factors was analyzed. HLA-DR2 appeared to be the strongest risk factor. N o evidence for synergy between DRI. DR2 and DRw9 was detected. DQwl was not significantly increased in patients in the absence of DRl and DR2, and thus it was not apparent in this study that DQwl was an independent risk factor.

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Section: Discussioncontrasting

confidence: 58%

HLA and leprosy in Koreans

et al. 1987

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“…Previous investigations demonstrated different class I HLA variants associated to TT and LL forms of leprosy, in several populations. In India, the most important country in number of infected individuals with the bacillus, an important association with leprosy was reported for HLA-B40 antigen and HLA-A2-B40, HLA-A11-B40, and HLA-A24-B40 haplotypes [20]. Further studies in India replicated these findings; HLA-A11 [21] and HLA-B60 (split of B40) [22] antigens were associated to the LL form.…”

Section: Hla and Leprosymentioning

confidence: 81%

HLA and Infectious Diseases

Cardozo¹,

Marangon²,

Sell³

et al. 2014

HLA and Associated Important Diseases

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HLA and Associated Important Diseases 260CD . During antigen presentation, CD and CD are intimately associated with the TCR and bind to the MHC molecule [ ].. Haplotype, linkage disequilibrium and HLA genes expression HL" genes are transmitted for Mendel segregation and allelic variant is expressed in a codominant mode. The set of HL" alleles present in each chromosome of the pair is denominated haplotype. The probability of a sibling having the same HL" haplotype as the other is %, different haplotypes is % and % are share only one haplotype [ ].Moreover, there is a fact that occurs in HL" genes called linkage disequilibrium which denotes that certain alleles occur together with a greater frequency than would be expected by chance non-random gametic association . Variations in the expected combinations of alleles in the population, more often or less often than would be expected from a random formation of haplotypes from alleles, could be related to linkage disequilibrium [ ]. For example, a determined population has a gene frequency of % for HLA-A* and % for HLA-B* , therefore the expected frequency for this haplotype would be . % . x . , the actual frequency is however, . % in this population, a higher frequency than expected, characterizing a positive linkage disequilibrium [ ].. HLA and infection diseasesThe frequency and the presence of HL" alleles vary among different populations. Studies suggest that the alleles that can confer resistance to certain pathogens are prevalent in areas with endemic diseases. Furthermore, genomic analysis in families has helped to map and identify the loci related to a number of diseases. Moreover, a number of diseases have been mapped and had their related loci identified thanks to the genomic analysis of families.

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“…In leprosy patients from Iran, HLA-B35 antigen was increased, while HLA-A1 was decreased in LL patients [10]. The HLA-B40 antigen and HLA-A2-B40, HLA-A11-B40, and HLA-A24-B40 haplotypes were frequent among Indian leprosy patients [11], while HLA-A11 and HLA-A33 were increased among Korean LL patients [13]. …”

Section: Classical Hla Class I Genesmentioning

confidence: 99%

Role ofHLA,KIR,MICA, and Cytokines Genes in Leprosy

Jarduli

Sell

Reis

et al. 2013

BioMed Research International

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Many genes including HLA, KIR, and MICA genes, as well as polymorphisms in cytokines have been investigated for their role in infectious disease. HLA alleles may influence not only susceptibility or resistance to leprosy, but also the course of the disease. Some combinations of HLA and KIR may result in negative as well as positive interactions between NK cells and infected host cells with M. leprae, resulting in activation or inhibition of NK cells and, consequently, in death of bacillus. In addition, studies have demonstrated the influence of MICA genes in the pathogenesis of leprosy. Specifically, they may play a role in the interaction between NK cells and infected cells. Finally, pro- and anti-inflammatory cytokines have been influencing the clinical course of leprosy. Data from a wide variety of sources support the existence of genetic factors influencing the leprosy pathogenesis. These sources include twin studies, segregation analyses, family-based linkage and association studies, candidate gene association studies, and, most recently, genome-wide association studies (GWAS). The purpose of this brief review was to highlight the importance of some immune response genes and their correlation with the clinical forms of leprosy, as well as their implications for disease resistance and susceptibility.

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HLA antigens in leprosy patients

Cited by 13 publications

References 4 publications

HLA and leprosy in Koreans

HLA and leprosy in Koreans

HLA and Infectious Diseases

Role ofHLA,KIR,MICA, and Cytokines Genes in Leprosy

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