HLA antigens in schistosomal hepatic fibrosis patients with haematemesis

Abstract

20 patients of schistosomal hepatic fibrosis and splenomegaly (SHF) with and without haematemesis were examined. Typing for HLA‐A, B and C antigens in these patients were compared with those of a group of 100 Egyptian controls. The study showed the presence of an association between HLA‐A1 and B5 antigens in SHF cases. However, there was no significant association between HLA antigens and SHF cases with haematemesis.

Factors controlling the effect of praziquantel on liver fibrosis inSchistosoma mansoni-infected patients

“…In addition to other factors, which include gender, age, duration and intensity of infection (Mohamed‐Ali et al , 1999), we have shown in the same cohort of patients that severe PPF is associated with an increase in TNF‐α production, and the progression to severe PPF in schistosomiasis was not associated with polymorphisms in the TNF‐α gene (Moukoko et al , 2003). It has also been reported that hepatomegaly associated with or without splenomegaly in patients with S. mansoni infection is influenced by HLA (Baza & Asser, 1985; Secor et al , 1996). The SM2 locus was found to be neither linked to SM1 nor to the HLA locus (Dessein et al , 1999b).…”