HLA Antigens in Ulcerative Colitis and Crohn's Disease in Israel

Delpre, G; Kadish, U; Gazit, Ephraim; Joshua, H; Zamir, R.

doi:10.1016/s0016-5085(19)30500-1

Cited by 79 publications

(20 citation statements)

References 21 publications

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“…Once corrections for multiple comparisons have been made, significant allele associations have been demonstrated in approximately half of these studies, but the results are inconsistent 78 , . 87 –96 The encouraging data from the recent chromosome 6 linkage studies may lead scientists to revisit the class 1 region using modern molecular typing methods.…”

Section: Replicated Significant Inflammatory Bowel Disease Linkage Rementioning

confidence: 99%

The genetics of inflammatory bowel disease

Ahmad

Satsangi

McGovern

et al. 2001

Aliment Pharmacol Ther

142

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Recent epidemiological, clinical and molecular studies have provided strong evidence that inherited predisposition is important in the pathogenesis of chronic inflammatory bowel diseases. The model most consistent with the epidemiological data suggests that Crohn’s disease and ulcerative colitis are related polygenic diseases, sharing some but not all susceptibility genes. Investigators throughout the world have applied the complementary techniques of genome‐wide scanning and candidate gene analysis. Four areas of linkage have been widely replicated on chromosomes 16 (IBD1), 12 (IBD2), 6 (IBD3—the HLA region), and most recently on chromosome 14. Fine mapping of these regions is underway. Of the ‘positional’ candidate genes, most attention has centred on the genes of the major histocompatibility complex. Genes within this region may determine disease susceptibility, behaviour, complications and response to therapy. Hope continues that studies of inflammatory bowel disease genetics will provide fresh insight into disease pathogenesis and soon deliver clinical applications.

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Section: Replicated Significant Inflammatory Bowel Disease Linkage Rementioning

confidence: 99%

The genetics of inflammatory bowel disease

Ahmad

Satsangi

McGovern

et al. 2001

Aliment Pharmacol Ther

142

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“…6 Asakura et al, on the basis of an increase of DR 2 in a Japanese population have suggested that immune responsiveness coded within HLA might play an important role in the pathogenesis of ulcerative colitis.7…”

mentioning

confidence: 99%

Ulcerative colitis and HLA phenotype.

Cottone¹,

Bunce²,

Taylor³

et al. 1985

Gut

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SUMMARYThe distribution of HLA A, B, C, DR antigens was investigated in a British population with ulcerative colitis. Fifty six patients were typed for HLA, A, B, C and 46 additionally for DR. No association was found between the HLA phenotype and the presence or absence of ulcerative colitis. Serum from 52 patients was tested for the presence of the anticolon antibody. There was no relation between the presence of the antibody and the HLA phenotype. Finally, no correlation was found between the HLA phenotypes, the age of onset of the disease, the extent and the clinical course.Ulcerative colitis is not a classical genetic disorder. The involvement of genetic factors is suggested by the familial aggregation' and the immune abnormalities found in patients2 and their relatives.3The search for an association between the disease and human histocompatibility antigens (HLA) has produced conflicting results.47 These differences have been explained on the basis of different genetic backgrounds of the patients studied.The association of HLA-AW24 in patients with an early onset of their disease reported in a Jewish population has lead to the suggestion that further attempts should be made to search for an association with age of onset, extent and severity of the disease.6 Asakura et al, on the basis of an increase of DR 2 in a Japanese population have suggested that immune responsiveness coded within HLA might play an important role in the pathogenesis of ulcerative colitis.7The aim here was to study the distribution of HLA A, B, C, DR antigens in a group of British patients suffering from ulcerative colitis and to investigate whether an association existed between HLA phenotype and age of onset, extent of disease, the clinical course and the presence of circulating antibodies to colonic epithelium.

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“…HLA-Bw35 is also associated with other autoimmune disorders (1 1. 18,22). Our patient had HLA-Bw35 and -DR2.…”

Section: Discussionmentioning

confidence: 60%

A Japanese case of ulcerative colitis associated with dermatitis herpetiformis and primary sclerosing cholangitis

et al. 1996

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: A number of extraintestinal complications of ulcerative colitis have been described. However, only a few cases of ulcerative colitis associated with dermatitis herpetiformis have been documented. We report a case of ulcerative colitis associated with dermatitis herpetiformis and primary sclerosing cholangitis in a Japanese woman. The patient first developed exanthema on the extremities at the age of 18 years. Subsequently, her skin disease was diagnosed as dermatitis herpetiformis with linear IgA deposits at the dermoepidermal junction. A biopsy specimen from the jejunum did not show villous atrophy. Subsequently, she was diagnosed with primary sclerosing cholangitis at age 34 years, and with ulcerative colitis 2 years later. The patient died of hepatic failure at age 40 years. Bile duct cancer was found at autopsy. Both dermatitis herpetiformis and primary sclerosing cholangitis are diseases of the immune system that are associated with HLA-B8 and -DR3 in whites. Our patient had neither of these serotypes. The immune mechanisms involved in the extraintestinal complications of inflammatory bowel disease are briefly discussed.

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HLA Antigens in Ulcerative Colitis and Crohn's Disease in Israel

Cited by 79 publications

References 21 publications

The genetics of inflammatory bowel disease

The genetics of inflammatory bowel disease

Ulcerative colitis and HLA phenotype.

A Japanese case of ulcerative colitis associated with dermatitis herpetiformis and primary sclerosing cholangitis

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