HLA‐B*15 subtypes in the population of north‐eastern Thailand

Abstract

The HLA-B*15 group is the most polymorphic HLA-B allele and so has several subtypes. These subtypes have not been defined in the population of north-eastern Thailand (NET). In a previous study, using polymerase chain reaction-sequence-specific primers (PCR-SSP), subtypes were categorized into four groups, namely: group I: HLA-B*15 (01, 04-07, 12, 14, 19, 20, 24, 25, 26N, 27, 32, 33, 34 and 35); group II: HLA-B*15 (02, 08, 11, 15, 28 and 30); group III: HLA-B*1503/4802; group IV: HLA-B*1521. Groups I and II occurred frequently (allele frequency = 8.0 and 2.5%), and thus we optimized the polymerase chain reaction-single-stranded conformation polymorphism (PCR-SSCP) method to identify HLA-B*15 subtypes of groups I and II. Eighty samples of DNA carrying HLA-B*15 from 300 healthy unrelated individuals were tested. B*1502 (52.5%) and B*1525 (13.8%) were the most common subtypes found in NET. They also showed strong linkage disequilibrium with HLA-Cw and heterogeneity of HLA-A, DR, DQ haplotypes. Although limited conclusions can be drawn from this study because of the small number of DNA references used, the baseline data will be useful in the selection of common HLA-B*15 alleles when subtyping for unrelated donor transplantations.

Pharmacogenomics in Psychiatric Disorders

“…Another study reported a positive association with HLA-B*1502 in 98% of 60 Han Chinese patients with the adverse drug reaction compared to 4% of patients who did not have the reaction [152,153]. Similar associations have been reported for other Asian populations, despite variability in the frequency of HLA-B*1502 in those populations (Figure 6.2) [155][156][157][158][159]. Similar associations have been reported for other Asian populations, despite variability in the frequency of HLA-B*1502 in those populations (Figure 6.2) [155][156][157][158][159].…”

Distribution of HLA alleles and haplotypes in Jinuo and Wa populations in Southwest China

“…Some predominant alleles in Chinese were rare in Wa such as A*0207 (0.8%), B*4601 (0.4%), and B*5502 (0.8%). On the other hand, rare alleles in the other populations showed high frequencies in Wa including A*3303 (16.0%), B*1532 (11.8%), and DRB1*1504 (13.4%): B*1532 was only reported in Thai and DRB1*1504 was in Chinese Dai [40,41]. In addition several hapoltypes were only found in Wa including A*1101-B*1532-DRB1*1504 (8.8%), A*1101-B*3501-DRB1*1404 (5.1%), and A*3303-B*3503-DRB1*1301 (4.6%).…”

Pharmacogenetic screening of carbamazepine-induced severe cutaneous allergic reactions

“…A high prevalence of 5% is also seen in Asians residing in North America. 32 The HLA-B ⁄ 1502 is one of the most common HLA-B alleles among Thai, 33 Burmese, 34 Vietnamese 35 and Western Javanese 36 but is rare in Caucasians. In a prior study of European populations, the allele frequency was only 1% to 2%.…”