HLA-B∗5101 in Greek Patients with Behçet’s Disease

Koumantaki, Yvonni; Stavropoulos, C.; Spyropoulou, M.; Messini, Helen; Papademetropoulos, Miltos; Giziaki, Ernestini; Marcomichelakis, N; Palimeris, Gerasimos; Kaklamanis, Phaedon; Kaklamani, E

doi:10.1016/s0198-8859(98)00011-1

Cited by 54 publications

(25 citation statements)

References 15 publications

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“…In 1993, Mizuki et al reported that HLA-B*5101, one of the HLA-B51 subantigens, was associated with Behçet's disease in Japanese patients. And Koumantaki et al reported that allele B*5101 was found in 80% of Behçet's disease patients and in 26% of controls in Greeks [30]. These results suggest that HLA antigen is related to the incidence of BD.…”

Section: Discussionmentioning

confidence: 94%

The correlation of MHC haplotype and development of Behçet's disease-like symptoms induced by herpes simplex virus in several inbred mouse strains

Sohn

Lee

2001

Journal of Dermatological Science

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Section: Discussionmentioning

confidence: 94%

The correlation of MHC haplotype and development of Behçet's disease-like symptoms induced by herpes simplex virus in several inbred mouse strains

Sohn

Lee

2001

Journal of Dermatological Science

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“…The genetic association of HLA-B5 (B51) with BD was initially reported in 1973 by Ohno and coworkers [24]. Subsequently this association has been confirmed in many different ethnic populations in Asia (Japanese [16,[24][25][26][27][28], Korean [29,30], Han Chinese [31], Taiwan Chinese [32], Turk [33][34][35][36][37], Israeli [38][39][40], Palestinian and Jordanian [41], Iranian [42], and Iraqi [43]), Southern Europe (Italian [44][45][46], Greek [47][48][49], Spanish [50], and German [17,51]), Northern Africa (Moroccan [55] and Tunisian [56]), North America (Mexican [59]), and South America (Brazilian [60]), but not in some populations in Northern Europe (British [35,52,53]) and North America (American [57,58]) ( Table 1). Although the odds ratio (OR) for the susceptibility risk of BD among carriers of HLA-B51 has been known to be much higher in the ethnic groups who live in endemic areas along the ancient Silk Road than in the American or British populations, recently published data have shown that the HLA-B51-associated risk could be significantly raised even among some other populations outside the ancient tradin...…”

Section: Mhc Genes (A) Hla-b51 Antigenmentioning

confidence: 89%

Update on the Molecular Genetic Studies of Behcets Disease

Chang

2005

CRR

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Although the pathogenesis of Behcet's disease (BD) is not fully elucidated, a genetic susceptibility to the disease appears to be affected by a polygenic inheritance, including the major histocompatibility complex (MHC) and non-MHC genes. As is true for the well-known regional differences in the disease expression of BD, a genetic susceptibility to BD appears to be different in various ethnic groups. Although HLA-B51 is a genetic factor with the strongest association in most ethnic populations who reside in countries adjacent to the ancient Silk Road, it is still uncertain whether this HLA molecule is directly involved in the pathogenesis of BD. In addition to HLA-B51, the association of BD with the MICA gene has been reported to be the consequence of linkage disequilibrium with HLA-B51, whereas the TNF-1031C allele among TNF gene polymorphisms has been observed to be another risk factor independent of the presence of HLA-B51 in UK Caucasoid patients with BD. Recently, intensive investigations on non-MHC genes, some of which are noted to be associated with a susceptibility to BD in several ethnic groups, are under way.

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“…In Chinese Han patients, B 5101 dominated, and a new as sociation between BD and HLA-B 46 was found. Remarkably, in Turkish, Jordanian, Iranian and Japanese BD patients, the whole nucleotide sequences of HLA-B 510101 genes, with the promoter and intron regions, are identical, proposing that B 510101 may have the same phylogenetic source [22][23][24][25][26][27][28][29][30][31].…”

Section: Genetic Susceptibility Of Behçet's Diseasementioning

confidence: 99%