HLA-B Alleles Associated with the B15 Serologically Defined Antigens

Steiner, Noriko; Ng, Jennifer; Bush, Janet; Hartzman, Robert J.; Johnston-Dow, L; Hurley, Carolyn Katovich

doi:10.1016/s0198-8859(97)00112-2

Cited by 34 publications

(24 citation statements)

References 19 publications

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“…Human leukocyte antigen (HLA) B15 represents a large, genetically diverse group of HLA-B alleles. It was first described and its heterogeneity recognized at the Fourth International Histocompatibility Workshop in 1970 (4th IHW) (Albert et al, 1970;Thorsby & Kissmeyer-Nielsen, 1970;Thorsby et al, 1970). At the 9th IHW, the heterogeneity of HLA-B15 was summarized and discussed by Chandanayingyong et al (1984) and Cambon-Thomsen et al (1984).…”

Section: Introductionmentioning

confidence: 99%

HLA‐B*15 subtypes in the population of north‐eastern Thailand

Romphruk

Phongaen²,

Chotechai³

et al. 2003

European Journal of Immunogenetics

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The HLA-B*15 group is the most polymorphic HLA-B allele and so has several subtypes. These subtypes have not been defined in the population of north-eastern Thailand (NET). In a previous study, using polymerase chain reaction-sequence-specific primers (PCR-SSP), subtypes were categorized into four groups, namely: group I: HLA-B*15 (01, 04-07, 12, 14, 19, 20, 24, 25, 26N, 27, 32, 33, 34 and 35); group II: HLA-B*15 (02, 08, 11, 15, 28 and 30); group III: HLA-B*1503/4802; group IV: HLA-B*1521. Groups I and II occurred frequently (allele frequency = 8.0 and 2.5%), and thus we optimized the polymerase chain reaction-single-stranded conformation polymorphism (PCR-SSCP) method to identify HLA-B*15 subtypes of groups I and II. Eighty samples of DNA carrying HLA-B*15 from 300 healthy unrelated individuals were tested. B*1502 (52.5%) and B*1525 (13.8%) were the most common subtypes found in NET. They also showed strong linkage disequilibrium with HLA-Cw and heterogeneity of HLA-A, DR, DQ haplotypes. Although limited conclusions can be drawn from this study because of the small number of DNA references used, the baseline data will be useful in the selection of common HLA-B*15 alleles when subtyping for unrelated donor transplantations.

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Section: Introductionmentioning

confidence: 99%

HLA‐B*15 subtypes in the population of north‐eastern Thailand

Romphruk

Phongaen²,

Chotechai³

et al. 2003

European Journal of Immunogenetics

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“…The B*4010 allele could be classified as an allele from the B*4001 group for exons 2, 3, and 4 [1,36]. The exon 5 sequence of this allele determined in this study was identical to the exon 5 sequence of the B*4001 group ( Figure 3).…”

Section: Exonmentioning

confidence: 52%

Elucidation of Exon 1, 4, and 5 Sequences of 39 Infrequent HLA-B Alleles

et al. 2005

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“…HLA‐B*15:33 was first described in April 1996 by Carolyn K. Hurley (cell i.d. GN00103, accession numbers , ) in a Caucasoid subject (Marsh, 1996; Steiner et al. , 1997).…”

Section: Six Amino Acid Motifs Possessed By Hla‐b15 Specificitiesamentioning

confidence: 99%

“…HLA-B*15:33 was first described in April 1996 by Carolyn K. Hurley (cell i.d. GN00103, accession numbers U49898, U49899) in a Caucasoid subject (Marsh, 1996;Steiner et al, 1997). It differs from B*15:01:01:01 by three bases (position 463 A>C, 477 G>C, 485 C>A) and from B*15:78:02 ⁄ 01 by one (485 C>A) and two base(s) (477 G>C, 485 C>A), respectively, in exon 3.…”

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confidence: 99%

HLA‐B*15:33, a rare allele whose product reacts as an HLA‐B62 and ‐Cw5/Cw8 specificity

Street

Climer

Johnson

et al. 2011

Int J Immunogenetics

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Using PCR with sequence-specific primers (SSP) and subsequent sequencing of exons 2 and 3, we identified an example of B*15:33 in a likely north-western European Caucasoid volunteer haemopoietic stem cell (HSC) donor. This was only the second example submitted to the IMGT/HLA database since B*15:33 was first described in 1996. B*15:33 differs from B*15:01:01:01 by three nucleotides resulting in two amino acid differences with B*15:01 (131S>R, 138T>K). This allele encodes a typical HLA-B62 specificity--as confirmed using 17 local antisera from parous women and 19 monoclonal antibodies directed towards B15, B62 and B63 specificities. Importantly, it also reacted as a Cw5/Cw8 specificity when tested against 21 Cw5, Cw5/Cw8 and Cw8 antisera. This Cw5/Cw8 reactivity is probably due to the B*15:33 specificity having lysine at position 138 which is possessed by numerous C*05 and many C*08 products. B*15:33 is likely to have derived from a HLA-B/C inter-locus gene conversion event. HLA-B*15:33 is clearly rare--this single example was found during the HLA PCR-SSP-based typing of 57,079 potential HSC donors. This indicates an allele frequency of <0.00001 in blood donors resident in Wales. An Epstein-Barr virus transformed B-cell line from the HLA-B*15:33 donor is available.

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HLA-B Alleles Associated with the B15 Serologically Defined Antigens

Cited by 34 publications

References 19 publications

HLA‐B*15 subtypes in the population of north‐eastern Thailand

HLA‐B*15 subtypes in the population of north‐eastern Thailand

Elucidation of Exon 1, 4, and 5 Sequences of 39 Infrequent HLA-B Alleles

HLA‐B*15:33, a rare allele whose product reacts as an HLA‐B62 and ‐Cw5/Cw8 specificity

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