HLA-B27 and Clinical Features of Acute Anterior Uveitis in Cuba

Sylvia, Torres; Borges, Sandra; Artiles, Adriana

doi:10.3109/09273948.2012.748080

Cited by 10 publications

(10 citation statements)

References 26 publications

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“…43 In a Chinese cohort, in addition to male preponderance, a younger age of onset was observed among male patients with HLA-B27-associated uveitis compared to females. Interestingly, male sex was also associated with increased risk of vision loss in a recent cohort in USA, 45 whereas another study from the Netherlands that focused on differences in outcomes based on gender indicated no gender differences in vision loss among HLA-B27-associated anterior uveitis patients.…”

Section: Non-infectous Uveitidesmentioning

confidence: 95%

Gender Disparities in Ocular Inflammatory Disorders*

Sen

Davis

Uçar

et al. 2014

Current Eye Research

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Ocular inflammatory disorders disproportionately affect women, and the majority of affected women are of childbearing age. The role of sex or reproductive hormones has been proposed in many other inflammatory or autoimmune disorders, and findings from non-ocular autoimmune diseases suggest a complex interaction between sex hormones, genetic factors and the immune system. However, despite the age and sex bias, factors that influence this disparity are complicated and unclear. This review aims to evaluate the gender disparities in prevalence, incidence and severity of the most common infectious and non-infectious ocular inflammatory disorders.

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Section: Non-infectous Uveitidesmentioning

confidence: 95%

Gender Disparities in Ocular Inflammatory Disorders*

Sen

Davis

Uçar

et al. 2014

Current Eye Research

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“…Ocular complications in HLA-B27-associated AU are diverse, and include commonly posterior synechiae, cataract, ocular hypertension, or glaucoma and hypotony (Table 3) . 25,30,31,34,35,39,60 Epiretinal membrane and band keratopathy can occur, but are less frequent. The incidence rate of any ocular complication was 0.22/ eye-year, which is lower than in other uveitis entities, such as juvenile idiopathic arthritis-associated uveitis or uveitis associated with Behcet disease.…”

Section: Visual Outcomes and Complicationsmentioning

confidence: 99%

“…Studies which include AU or AAU patients solely, usually indicate a higher frequency of HLA-B27-associated uveitis of approximately 33-67% across different racial groups, except in one study from Saudi Arabia, in which HLA-B27-associated uveitis was only 0.6% (Table 2) . 5,[30][31][32][33][34][35][36][37] In addition to genuine differences, these distinctions might be a consequence of variable referral to tertiary centers and might be also influenced by an inconsistent work-up for uveitis, including the testing for HLA-B27. Similarly, the frequency of systemic disease associated with HLA-B27associated uveitis seems to be lower in Japan (1.3%), India (15%), and Thailand (15%) when compared with Western countries (~50%).…”

mentioning

confidence: 99%

Clinical Spectrum of HLA-B27-associated Ocular Inflammation

Pathanapitoon

Dodds

Cunningham

et al. 2016

Ocular Immunology and Inflammation

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Human leukocyte antigen (HLA)-B27-associated anterior uveitis (AU) is the most commonly diagnosed form of AU and represents the largest entity of non-infectious uveitis around the world. The most typical ocular manifestation associated with HLA-B27 consists of unilateral AU of acute onset. The HLA-B27-associated acute AU represents a distinct clinical entity occurring typically in young adults between the ages of 20 and 40 years. HLA-B27-associated acute AU is typically unilateral and lasts usually several weeks and diminishes within 3 months in the majority of patients. The anterior chamber shows typically severe cellular reaction and flare, as well as a fibrinous exudate. Frequently, posterior synechiae are formed and occasionally hypopyon is present. The pattern of the disease is recurrent with a full remission between the attacks. Intraocular pressure during active periods is typically low due to inflammation of ciliary body and decreased aqueous production. Less typical presentations are also recognized and include the development of chronic inflammation, posterior segment involvement, episcleritis, and scleritis. An isolated retinal vasculitis in HLA-B27-positive patients may develop, mostly in those with inflammatory bowel disease. Chronic AU, which may be either unilateral or bilateral affects up to 20% of patients. Ocular complications of HLA-B27-associated AU are diverse and include commonly posterior synechiae, cataract, glaucoma and/or hypotony. The visual outcome and complications of HLA-B27-associated AAU are frequently being compared with HLA B27-negative patients with AU and show that the prognosis of HLA-B27-associated uveitis is rather favorable, as <2% developed legal blindness and <5% visual impairment. A novel algorithm called the "Dublin Uveitis Evaluation Tool (DUET)" has been proposed to guide ophthalmologists to refer appropriate HLA-B27-positive patients with uveitis to rheumatologists.

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“…The HLA-B27 is considered to be strongly associated with both AAU and AS [5, 8, 10, 14]. Recent genetic studies have revealed that five candidate genes in the JAK-STAT signaling pathway were considered genetic predisposing factors for different autoimmune-mediated diseases [38–45].…”

Section: Discussionmentioning

confidence: 99%

“…Evidence suggests that the occurrence of AAU is associated with the prognosis of ankylosing spondylitis (AS) [6, 7]. The frequency of AAU, which is characterized by positive human leukocyte antigen- (HLA-) B27, varies across different ethnic populations [8–10]. In the United States and Western Europe, the prevalence of HLA-B27 with AAU is up to 50% [5, 8, 11].…”

Section: Introductionmentioning

confidence: 99%

Lack of Association between Genetic Polymorphisms of JAK-STAT Signaling Pathway Genes and Acute Anterior Uveitis in Han Chinese

Cheng

Jiang

et al. 2016

BioMed Research International

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Purpose. This study aimed to investigate the association between single nucleotide polymorphisms (SNPs) of JAK-STAT signaling pathway genes and acute anterior uveitis (AAU) with or without ankylosing spondylitis (AS) in the Han Chinese population. Methods. Eleven SNPs of the JAK1, JAK2, STAT1, IRF1, and NOS2 genes were analyzed in 443 AAU patients with AS, 486 AAU patients without AS, and 714 healthy controls. Genotyping was performed by PCR-RFLP assay or TaqMan® probe assay. The Chi-squared (χ 2) test and multivariate logistic regression analysis were used to compare the distributions of alleles and genotypes between patients and controls. P values were adjusted using Bonferroni correction. Results. We did not observe significant differences in the genotype and allele frequencies of any SNP between AAU patients with or without AS and healthy controls. Stratification analyses by gender and HLA-B27 status showed a boundary significant association between two SNPs (rs10975003 and rs10758669) in JAK2 and AAU (P = 0.052 and P = 0.053, resp.). Conclusions. Our results indicated that genetic polymorphisms of the JAK-STAT signaling pathway genes may not be associated with AAU in the Han Chinese population.

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HLA-B27 and Clinical Features of Acute Anterior Uveitis in Cuba

Abstract: Results from this study are similar to data described in other countries. HLA-B27 allele distribution in controls is lower than other reports in Caucasian populations.

Cited by 10 publications

References 26 publications

Gender Disparities in Ocular Inflammatory Disorders*

Gender Disparities in Ocular Inflammatory Disorders*

Clinical Spectrum of HLA-B27-associated Ocular Inflammation

Lack of Association between Genetic Polymorphisms of JAK-STAT Signaling Pathway Genes and Acute Anterior Uveitis in Han Chinese

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