HLA B27 Subtype Distribution Among Patients with Ankylosing Spondylitis in Eastern Turkey

Abstract

Human leukocyte antigen (HLA) B27 has a strong association with ankylosing spondylitis (AS) and other spondyloarthropathies. More than 70 subtypes of HLA B27 have been described. The present study investigated B27 subtype distribution among B27-positive patients with AS classified according to the modified New York criteria and healthy controls. Sequence-specific primer polymerase chain reaction technique was used for B27 subtyping of 43 unrelated patients with AS and 39 volunteer bone marrow donors. Among patients with AS, the male-female ratio was 6.2 and the mean age was 30 years. No relationship was found between the B27 subtypes and clinical and laboratory findings in patients with AS (p>0.05). Similarly, the frequencies of B27 subtypes did not significantly differ between patients and controls. In this study, B*2746, B*2749, and B*2767 subtypes were detected for the first time. Among B27 subtypes, the most common B27 alleles found in the patients and the controls were B*2702 and B*2705. In addition, B*2702 subtype was found predominantly in both patients (48.8%) and controls (46.2%). In conclusion, in addition to commonly encountered B*2702 and B*2705 HLA subtypes, a B*2749 subtype in a patient with AS and B*2746 as well as B*2767 subtypes in controls were determined for the first time.

Distribution of HLA-B*27 Subtypes in Patients with Ankylosing Spondylitis in Local Population

“…12 In Iran and Turkey, HLA-B*27:02 and HLA-B*27:05 are common AS associated alleles. 6,13 HLA-B*27:07 was found as the predominant allele in AS patients in current study, followed by HLA-B*27:03 and HLA-B*27:05. These findings are supported by other studies conducted globally.…”

Association of HLA-B27 Gene and Rheumatoid Arthritis: Analysis of Potential Role as a Predictive Biomarker

“…A study of HLA-B27 Subtypes in Iranian patients with Ankylosing Spondylitis detected two subtypes, B*2705 (63.4%) and B*2702 (36.6%) [31]. Meanwhile, B*2746, B*2749, B*2767, B*2702 and B*2705 subtypes were detected among Ankylosing Spondylitis patients in Turkey [32]. HLA-B27 was shown to have highest prevalence in ankylosing spondylitis and least prevalence in juvenile rheumatoid arthritis among Iranian population [33].…”

Association between Klebsiella pneumoniae and ankylosing spondylitis: A systematic review and meta‐analysis

“…AS occurs most commonly in the 20s age group, and males are more susceptible 2 . Genetic factors are thought to be related to AS 3‐8 . It has been reported that more than 90% of AS patients carry the human leukocyte antigen (HLA)‐B27 gene 9 .…”

“…2 Genetic factors are thought to be related to AS. [3][4][5][6][7][8] It has been reported that more than 90% of AS patients carry the human leukocyte antigen (HLA)-B27 gene. 9Enterobacteria infection, 10 such as with Klebsiella pneumoniae, Proteus mirabilis, Escherichia coli, was deemed in previous studies to be another risk factor causing AS.Among Enterobacteria, K. pneumoniae has received the most attention.…”

“…2 Genetic factors are thought to be related to AS. [3][4][5][6][7][8] It has been reported that more than 90% of AS patients carry the human leukocyte antigen (HLA)-B27 gene. 9…”