HLA class I association with progression to end-stage renal disease in patients from Zulia, Venezuela

Rivera, Pérez; Márquez, Georgina; Cipriani, Adriano; Hassanhi, Manzur; Villalobos, Carmen; Fuenmayor, Alonso; Chavez, M. Colas; Montiel, Milagros

doi:10.1016/j.inmuno.2011.12.001

Cited by 15 publications

(15 citation statements)

References 21 publications

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“…The role of the HLA system in the pathophysiology of ESRD is intriguing, but not completely resolved. Numerous associations and non-associations of HLA with ESRD have been reported in the medical literature, but with controversial results in Table 1 [82][83][84][85][86][87][88][89][90][91][92][93].…”

Section: Hla and End-stage Renal Diseasementioning

confidence: 99%

Clinical Role of Human Leukocyte Antigen in Health and Disease

2015

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Most of the genes in the major histocompatibility complex (MHC) region express high polymorphism that is fundamental for their function. The most important function of human leukocyte antigen (HLA) molecule is in the induction, regulation of immune responses and the selection of the T cell repertoire. A clinician's attention is normally drawn to a system only when it malfunctions. The HLA system is no exception in this regard, but in contrast to other systems, it also arouses interest when it functions well -too well, in fact. Population studies carried out over the last several decades have identified a long list of human diseases that are significantly more common among individuals that carry particular HLA alleles including inflammatory, autoimmune and malignant disorders. HLAdisease association is the name of this phenomenon, and the mechanism underlying is still a subject of hot debate. Social behaviours are affected by HLA genes and preference for HLA disparate mates may provide 'good genes' for an individual's offspring. Also, certain HLA genes may be associated with shorter life and others with longer lifespan, but the effects depend both on the genetic background and on the environmental conditions. The following is a general overview of the important functional aspects of HLA in health and diseases.

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Section: Hla and End-stage Renal Diseasementioning

confidence: 99%

Clinical Role of Human Leukocyte Antigen in Health and Disease

2015

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“…HLA-B*15 was found to be positively associated with ESRD by four separate works [12,14,17,18]. HLA-B*55 [14] [19] and HLA-B*53 [13,20] were observed to be positively associated with ESRD in two studies. On the other hand, HLA-B*52 was negatively associated with ESRD in two studies [13,21].…”

Section: Discussionmentioning

confidence: 99%

Revisiting the Association between Human Leukocyte Antigen and End-Stage Renal Disease

Noureen

Shah

Lisec

et al. 2020

Preprint

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Multiple works have studied possible associations between human leukocyte antigen (HLA) alleles and end stage renal disease (ESRD). However, there are several contradictions in these previous works and no consistent HLA associations with ESRD itself have been identified. Most of these works have several limitations, for instance, the population size was too small, or only limited HLA loci were studied. The presented work aims to revisit the association between ESRD and HLA antigens while taking in to account the previously overlooked limitations. Here, we compared the HLA polymorphism (at HLA-A, -B, -C, -DRB1, -DQB1 and DQA1 loci) in ESRD patients (n=497) and controls (n=672). Our data identified several HLA alleles that displayed a significant positive or negative association with ESRD.We also determined whether heterozygosity or homozygosity of the ESRD-associated HLA alleles at different loci could modify the prevalence of the disease. Few HLA allele combinations displayed significant associations with ESRD among which HLA-A*3 -HLA-A*26 combination showed the highest strength of association (OR= 4.488, P≤ 0.05) with ESRD.However, the age of ESRD onset was not affected by HLA allele combinations at different loci.Most of the previous works have studied the association of HLA with ESRD in homogeneous ethnic groups and have interpreted their data accordingly. Here, we also performed an extensive literature analysis to determine whether the association of HLA to ESRD can be similar across different ethnic groups. This analysis showed that at least for certain alleles, the association of HLA to ESRD can be similar in different ethnic groups. For instance, HLA-A*11, HLA-DRB1*11, and HLA-DRB1*4 all showed significant positive associations with ESRD in different ethnic groups. The findings of our study will help in determining possible protective or susceptible roles of various HLA alleles in ESRD.

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“…38 In the same time, the HLA-B38, B51, B53 and B62 were positively associated with ESRD and the HLA-A9, B12, B17, B40 and B48 were negatively associated in population from Venezuela. 9 Therefore, the development of ESRD is associated with different HLA in different ethnic population, different races of the same population and sometimes the results may be contradictory. These findings can be explained by the difference in patients and controls number between studies, different techniques used for HLA-typing, different etiologic factors leading to ESRD, different ethnic and genetic background of each population.…”

Section: Discussionmentioning

confidence: 99%

“…8 These observations resulted in the search for positive associations between Human Leukocyte Antigens (HLAs) and a wide range of renal diseases. 9 The MHC (Major Histocompatibility Complex) is a highly polymorphic cluster of genes with some of the greatest allelic diversity in the genome. MHC genes are both polygenic (containing multiple genes) and polymorphic (containing multiple variants of each gene).…”

Section: Introductionmentioning

confidence: 99%

Association between Human Leukocyte Antigens (HLA-A, -B, and -DR) and end-stage renal disease in Kuwaiti patients awaiting transplantation

Mosaad

Mansour

Al-Muzairai³

et al. 2014

Renal Failure

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The number of patients with end stage renal disease (ESRD) is increasing considerably worldwide. Human Leukocyte Antigens (HLAs) are relevant for the expression of many immunological diseases and contribute to the development of different nephropathies. Therefore, we aimed from the present work to investigate the possible association between the frequency of HLA-A, -B, and -DR antigens and ESRD in Kuwaiti patients awaiting renal transplant. HLA-A, -B, and -DR typing was performed by complement-dependent cytotoxicity (CDC) method for 334 patients with ESRD awaiting renal transplantation and 191 healthy controls. The frequency of HLA-B8 antigen was significantly higher in ESRD patients (OR = 2.62, p = 0.001, pc = 0.038), and the frequency of HLA-A28, HLA-DR11 antigens was significantly higher in healthy controls (OR 0.42, p = 0.0001; pc = 0.0021, and OR = 0.44, p = 0.0007, pc = 0.01 respectively). While the HLA-B8 antigen may be a susceptibility risk factor for development of ESRD, the HLA-A28, and HLA-DR11 antigens may be protective against development of ESRD in Kuwaiti population.

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HLA class I association with progression to end-stage renal disease in patients from Zulia, Venezuela

Cited by 15 publications

References 21 publications

Clinical Role of Human Leukocyte Antigen in Health and Disease

Clinical Role of Human Leukocyte Antigen in Health and Disease

Revisiting the Association between Human Leukocyte Antigen and End-Stage Renal Disease

Association between Human Leukocyte Antigens (HLA-A, -B, and -DR) and end-stage renal disease in Kuwaiti patients awaiting transplantation

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