HLA Class II influences humoral autoimmunity in patients with type 2 autoimmune hepatitis

Djilali-Saiah, Idriss; Fakhfakh, Amin; Louafi, Hamida; Caillat‐Zucman, Sophie; Debray, Dominique; Álvarez, Fernando

doi:10.1016/j.jhep.2006.07.034

Cited by 89 publications

(38 citation statements)

References 41 publications

(49 reference statements)

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“…31 In a Canadian study, DQB1*0201 was found to be primarily responsible for the increase in the susceptibility to AIH type 2. 32 In another study, American and German patients with AIH type 2 had significantly higher frequency of DRB1*07, DRB1*15 and DQB1*06 33 compared to controls. In our cohort, patients with AIH type 2 were found to be significantly associated with DRB1*14.…”

Section: Discussionmentioning

confidence: 93%

HLA DRB1 Alleles Discriminate the Manifestation of Autoimmune Hepatitis as Type 1 or Type 2 in North Indian Population

Kaur

Minz

Anand

et al. 2014

Journal of Clinical and Experimental Hepatology

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Background: Autoimmune hepatitis is a polygenic disorder of unknown etiology, where genetic factors affect the occurrence and clinical phenotype of the disease. It has been reported as a rare disease entity in the Indian subcontinent. This study was undertaken to investigate the association of HLA alleles with autoimmune hepatitis type 1 and type 2 in north Indian population and to analyze if distinct human leukocyte antigen (HLA) alleles help in characterization of the subtypes of autoimmune hepatitis. Methods: Sixty-eight patients with autoimmune hepatitis and 128 healthy controls were recruited in the study. Out of 68 patients, 55 were diagnosed with autoimmune hepatitis type 1 and 13 with autoimmune hepatitis type 2. The patients and the controls were typed for HLA class II alleles by PCR-SSP method. Results: HLA DRB1*04 and DRB1*08 were found to be significantly associated with autoimmune hepatitis type 1 in north Indian population. It was also observed that DRB1*04, DRB1*13 were significantly associated with pediatric autoimmune hepatitis type 1 and DRB1*08 was significantly associated with adult autoimmune hepatitis type 1. DRB1*14 was significantly associated with autoimmune hepatitis type 2. Conclusion: The study indicates that autoimmune hepatitis in north Indian population is associated with HLA alleles that may help to discriminate the subtypes as autoimmune hepatitis type 1 and type 2. The study also highlights the ethnic variations in the Indian subcontinent in context to the genetic association of HLA with autoimmune diseases. ( J CLIN EXP HEPATOL 2014;4:14-18)

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Section: Discussionmentioning

confidence: 93%

HLA DRB1 Alleles Discriminate the Manifestation of Autoimmune Hepatitis as Type 1 or Type 2 in North Indian Population

Kaur

Minz

Anand

et al. 2014

Journal of Clinical and Experimental Hepatology

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“…In a study by Bittencourt et al (34), patients with type 2 AIH had significantly higher frequency of DRB1*07, DRB4 and DQB1*02 compared to controls. In a Canadian study, DQB1*0201 was found to be primarily responsible for the increase in the susceptibility to type 2 AIH (35). In another study, American and German patients with type 2 AIH had significantly higher frequency of DRB1*07, DRB1*15 and DQB1*06 compared to controls (36).…”

Section: Discussionmentioning

confidence: 97%

Relations between human leukocyte antigens and autoimmune hepatitis in Turkish children

Gulec

Urgancı²,

Polat³

et al. 2011

Turk J Gastroenterol

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“…It reacts with CYP2D6 antigens, but can be positive in up to 5% of hepatitis C patients (23) .As previously pointed out, patients with AIH-2 are younger, have lower levels of gamaglobulin, carry more frequently HLA-DR7 and/or -DQ2 genotypes and are more prone to have FHF at presentation, when compared to their counterparts with AIH-1 (24,25) . Other AA can be tested to better characterize AIH patients without those aforementioned conventional antibodies.…”

Section: Diagnosismentioning

confidence: 93%

Brazilian society of hepatology recommendations for the diagnosis and management of autoimmune diseases of the liver

Bittencourt

Cançado

Couto

et al. 2015

Arq. Gastroenterol.

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-In order to draw evidence-based recommendations concerning the management of autoimmune diseases of the liver, the Brazilian Society of Hepatology has sponsored a single-topic meeting in October 18th, 2014 at São Paulo. An organizing committee comprised of seven investigators was previously elected by the Governing Board to organize the scientific agenda as well as to select twenty panelists to make a systematic review of the literature and to present topics related to the diagnosis and treatment of autoimmune hepatitis, primary sclerosing cholangitis, primary biliary cirrhosis and their overlap syndromes. After the meeting, all panelists gathered together for the discussion of the topics and the elaboration of those recommendations. The text was subsequently submitted for suggestions and approval of all members of the Brazilian Society of Hepatology through its homepage. The present paper is the final version of the reviewed manuscript organized in topics, followed by the recommendations of the Brazilian Society of Hepatology.

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HLA Class II influences humoral autoimmunity in patients with type 2 autoimmune hepatitis

Cited by 89 publications

References 41 publications

HLA DRB1 Alleles Discriminate the Manifestation of Autoimmune Hepatitis as Type 1 or Type 2 in North Indian Population

HLA DRB1 Alleles Discriminate the Manifestation of Autoimmune Hepatitis as Type 1 or Type 2 in North Indian Population

Relations between human leukocyte antigens and autoimmune hepatitis in Turkish children

Brazilian society of hepatology recommendations for the diagnosis and management of autoimmune diseases of the liver

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