HLA class II molecular polymorphisms in healthy Slavic individuals from North‐Western Russia

Abstract

Polymerase chain reaction (PCR)-based genotyping was used to characterize the features of HLA class II molecular polymorphisms in a Slavic population of North-Western Russia. Two hundred individuals were analyzed for the DRB1 gene, and 100 persons randomly selected from this cohort were additionally typed for DQA1, DQB1 and DPB1 genes. Allele and haplotype frequencies were found to be similar to those observed in other Caucasian populations, with the exception of considerably high prevalence of the DPB1*0301 allele (16.0%) in the group studied. The high rate of diversity was observed within DRB1*04 and DRB1*14 specificities, as well as for extended DR-DQ haplotypes. In addition, significant number of "unusual" DR-DQ linkage patterns have been detected. The data seem to reflect the complexity of ethnic background of "European" Russians and may be helpful for the development of international network between donor registries.

Human leukocyte antigen–A, -B, -C, -DRB1 allele and haplotype frequencies in Americans originating from southern Europe: Contrasting patterns of population differentiation between Italian and Spanish Americans

“…Arlequin v3.11 [20] was used to compare the HLA-A-C-B haplotypes and DRB1 genotypes in this population to those for Sub-Saharan African populations from Kenya [7,21], Mali [21], Rwanda [7], Senegal [7], South Africa [7], Uganda [21], Zambia [21], and Zimbabwe [7]; North African populations from Morocco [22–25] and Algiers [22]; European populations from Bulgaria [7] [26], Croatia [27], the Czech Republic [7,28], Finland [7], Georgia [7,29], Germany [30], Italy [31−34], Macedonia [35,36], Northern Ireland [7], Norway [37,38], Poland [39,40], Portugal [41], Russia[42], Slovenia [7,43], Spain [40,44–47], and Sweden [48]; Asian populations from India [49], and Israel [50]; two African American populations [2,51], five European American populations [52–54] [51,55], and a Mexican American population [56] by calculating pairwise F st values (and associated p-values), and an exact test of population differentiation [57] for this entire set of populations using DRB1 allele frequencies and A-C-B haplotype frequencies. These tests evaluate population differences using different null-hypotheses; p-values for pairwise F st values are generated under the assumption that there is no difference in allele frequency between population samples, whereas the exact test assumes random mating (panmixia) between population samples.…”

Origin and affinities of indigenous Siberian populations as revealed by HLA class II gene frequencies

“…0404 03 0302 2.9 ---4.0 5.7 0.7 -2.9*** ---3.9** 5.2*** 0.7*** -18 Grahovac et al 1998), and as an apparent admixture in one European population (Russians, 3.7%; Kapustin et al 1999). This haplotype may have arisen in East Siberia and then spread to the Americas with the early colonizers.…”

First Report on HLA-DPB1Gene Allelic Distribution in the General Lebanese Population

“…The allelic frequencies for HLA-DPB1 in healthy Lebanese individuals are listed in Table 1 and compared with the frequencies reported in several populations such as Spanish (Perez-Miranda et al, 2004), Tunisian (Ayed et al, 2004), Chinese (Blang and Puyi communities) (Wang et al, 2008), Kuwaiti (Alsaeid et al, 2006), Greek (Papassavas et al, 2000), Russian (Kapustin et al, 1999), Caucasian, and African (Aldener-Cannavá and Olerup, 2001). The allele frequencies in the Lebanese population were calculated by a direct counting method.…”

“…Lebanon is a country in western Asia, on the eastern shore of the Mediterranean Sea. Its location at the crossroads of the East and the West with a history of invasions by different nations has formed its unique identity of religious, ethnic, and genetic diversity.The aim of this study was to detect the HLA-DPB1 alleles in a selected healthy Lebanese population and to compare it with the existing published literature of various populations such as the Spanish (Pérez-Miranda et al, 2004), Tunisian (Ayed et al, 2004), Chinese (Wang et al, 2008), Kuwaiti (Alsaeid et al, 2006), Greek (Papassavas et al, 2000), Russian (Kapustin et al, 1999), Caucasian, and African (Aldener-Cannavá and Olerup, 2001).…”