HLA dictionary 2004: Summary of HLA-A, -B, -C, -DRB1/3/4/5, -DQB1 alleles and their association with serologically defined HLA-A, -B, -C, -DR, and -DQ antigens

Abstract

This report presents serologic equivalents of human leukocyte antigen (HLA)-A, -B, -C, -DRB1, -DRB3, -DRB4, -DRB5, and -DQB1 alleles. The dictionary is an update of the one published in 2001. The data summarize equivalents obtained by the World Health Organization (WHO) Nomenclature Committee for Factors of the HLA System, the International Cell Exchange (UCLA), the National Marrow Donor Program, recent publications, and individual laboratories. This latest update of the dictionary is enhanced by the inclusion of results from studies performed during the 13th International Histocompatibility Workshop and from neural network analyses. A summary of the data as recommended serologic equivalents is presented as expert assigned types. The tables include remarks for alleles, which are or may be expressed as antigens with serologic reaction patterns that differ from the well-established HLA specificities. The equivalents provided will be useful in guiding searches for unrelated hematopoietic stem cell donors in which patients and/or potential donors are typed by either serology or DNA-based methods. The serological-DNA equivalent dictionary will also aid in typing and matching procedures for organ transplant programs whose waiting lists of potential donors and recipients are comprised of mixtures of serologic and DNA-based typings. The tables with HLA equivalents and a questionnaire for submission of serologic reaction patterns for poorly identified allelic products will be made available through the World Marrow Donor Association Web page (www.worldmarrow.org).

False negative antibody-based HLA-A29 typing in two patients with birdshot chorioretinopathy

“…PCR-based techniques for HLA subtyping have emerged more recently, however, and have been shown to be more sensitive and specific than antibody-based approaches, including testing for HLA-A29 expression 5 6. While our report represents the first description of false negative antibody-based HLA-A29 testing, similarly false negative outcomes have been reported in patients tested for HLA-B27 expression 7.…”

Major histocompatibility complex (MHC) class II alleles, haplotypes and epitopes which confer susceptibility or protection in systemic sclerosis: analyses in 1300 Caucasian, African-American and Hispanic cases and 1000 controls

“…These three alleles constitute a haplotype with most DRB*11 alleles including both DRB1*1101 and DRB1*1104 36. Given the highest odds ratio (OR = 2.48) being conferred by DRB1*1104 rather than DQA1*0501 (OR = 2.29) or DQB1*0301 (OR = 1.50), the primary associated allele appeared likely to be DRB1*1104 in a dominant model.…”

Role of human leukocyte antigen class I alleles in progressive multifocal leukoencephalopathy

“…HLA class I typing for all HIV+ control patients was performed following the PCR-SSOP (sequence-specific oligonucleotide probing) typing protocol recommended by the International Histocompatibility Working Group (http://www.ihwg.org/). The four digit classification was converted into two digit classification and the serological two digit classification was converted into two-digit immunological classification in accordance with the HLA Dictionary nomenclature (Schreuder et al , 2005). …”