HLA-DQ types of celiac disease in Libyan children with type 1 diabetes mellitus

Ghawil, Millad; Miotti, Valeria; Tonutti, Elio; Tenore, Alfred; Hadeed, Ibtisam; Sindici, Chiara; Visentini, Daniela; Morgham, Amel; Abusrewil, S. S.

doi:10.1097/meg.0b013e32834d09d4

Cited by 16 publications

(17 citation statements)

References 24 publications

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“…An increased risk of this haplotype combination has been reported in T1D w/CeD cohorts previously. The number of T1D w/CeD patients being DRB1*03:01‐DQB1*02:01‐DQA1*05:01/DRB1*04‐DQB1*03:02‐DQA1*03 heterozygous in our study is similar to the findings of Gutierrez‐Achury et al, which is higher than previously reported in several publications with 0‐21% being heterozygous . Although, not as high as the reported 66% by Larsson et al Most previous studies have included few individuals (<40), with the exception of Bakker et al reporting on 118 patients (92 of which were HLA typed), the publication by Gutierrez‐Achury et al using HLA tagSNPs on 543 patients, and Smigoc Schweiger et al presenting 130 patients.…”

Section: Discussionsupporting

confidence: 87%

“…The number of T1D w/CeD patients being DRB1*03:01-DQB1*02: 01-DQA1*05:01/DRB1*04-DQB1*03:02-DQA1*03 heterozygous in our study is similar to the findings of Gutierrez-Achury et al, 22 which is higher than previously reported in several publications with 0-21% being heterozygous. 23,[31][32][33] Although, not as high as the reported 66% by Larsson et al 34 Most previous studies have included few individuals (<40), with the exception of Bakker et al 23 reporting on 118 patients (92 of which were HLA typed), the publication by Gutierrez-Achury et al 22 using HLA tagSNPs on 543 patients, and Smigoc Schweiger et al 21 presenting 130 patients. Our findings are in line with the 2 latter studies 21,22 that DRB1*03:01-DQB1*02:01-DQA1*05:01/DRB1*04-DQB1*03:02-DQA1* 03 heterozygous individuals with T1D show the highest risk of coexisting CeD.…”

Section: Discussionmentioning

confidence: 96%

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HLA class II alleles in Norwegian patients with coexisting type 1 diabetes and celiac disease

Viken

Flåm

Skrivarhaug

et al. 2017

HLA

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 96%

HLA class II alleles in Norwegian patients with coexisting type 1 diabetes and celiac disease

Viken

Flåm

Skrivarhaug

et al. 2017

HLA

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“…Sixty‐two studies on the prevalence of CD in patients with type 1 diabetes were included in this review . The prevalence of EMA positivity ranged from 0% to 13.83%; that of elevated tTG levels ranged from 0.81% to 21.16%, while 0.40% to 12.16% showed villous atrophy, ‘flat biopsies’ or Marsh 3 histological changes.…”

Section: Resultsmentioning

confidence: 99%

Systematic review: worldwide variation in the frequency of coeliac disease and changes over time

Kang

Green

et al. 2013

Aliment Pharmacol Ther

231

182

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Summary Background Coeliac disease (CD), originally thought to be largely confined to Northern Europe and Australasia and uncommon in North America and the Middle East, is now recognised to be equally common in all these countries. It is still thought to be rare in the Orient and Sub‐Saharan Africa. Aim To assess geographical differences and time trends in the frequency of CD. Methods Medline and Embase searches were conducted on 10 November 2012, from 1946 and 1980 respectively, using the key words: coeliac disease or celiac disease + prevalence or incidence or frequency. Results There were significant intra‐ and inter‐country differences in the prevalence and incidence of CD. Only 24 ethnic Chinese and Japanese patients have been reported in the English literature. Of CD‐associated HLA DQ antigens, DQ2 occurs in 5–10% of Chinese and sub‐Saharan Africans, compared to 5–20% in Western Europe. DQ8 occurs in 5–10% of English, Tunisians and Iranians, but in <5% of Eastern Europeans, Americans and Asians. The prevalence and incidence of both clinically and serologically diagnosed CD increased in recent years. These geographical and temporal differences seem genuine, although variable indices of suspicion and availability of diagnostic facilities are confounding factors. Conclusions Coeliac disease is increasing in frequency, with significant geographical differences. Although few cases have been described to date in the Orient and Sub‐Saharan Africa, there is a significant prevalence of HLA DQ2 and wheat consumption is of the same order as that in Western Europe. CD may therefore become more common in the future in these countries.

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“…In a recent study of T1DM children the biopsy‐confirmed prevalence of CD was 11% (24 of 218); among those with CD, 75% had HLA‐DQ2, 21% had HLA‐DQ2/DQ8, and 4% had HLA‐DQ8. In addition, the 70% carried HLA‐DQ2 linkage with HLA‐DRB1*03 . The prevalence of CD in T1DM has been studied extensively.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the 70% carried HLA-DQ2 linkage with HLA-DRB1*03. 52 The prevalence of CD in T1DM has been studied extensively. The Agency for Healthcare Research Report that included 21 studies and two additional studies reported that the prevalence of CD was 3-12%.…”

Section: Discussionmentioning

confidence: 99%