HLA DQB1*0401 is associated with the development of atrophic gastritis in H. pylori-infected patients

Sakai, Toshiyuki; Aoyama, Norio; Satonaka, Kazuhiro; Shigeta, Satomi; Yoshida, Hajime; Shirakawa, K.; Iida, Tomoya; Shinoda, Yukiko; Ikemura, Takahiro; Sakashita, Masanori; Shirasaka, Daisuke; Miyamoto, Masaki; Kasuga, Masato

doi:10.1016/s0016-5085(98)81115-3

Cited by 7 publications

(16 citation statements)

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“…reported that DRB1*1601 was associated with gastric adenocarcinoma. We reported the DQB1*0401 plays an important role in the development of atrophic gastritis in H. pylori infected patients 7 . Although Lee et al 11 .…”

Section: Discussionmentioning

confidence: 79%

“…Genomic DNA was obtained from peripheral blood leukocytes and HLA‐DQB1 genotype was defined by the polymerase chain reaction (PCR)‐restriction fragment length polymorphism (RFLP) method 20 . PCR primers for amplification and restriction endonuclease for genotyping of DQB1 alleles were as described previously 7 …”

Section: Methodsmentioning

confidence: 99%

“…Little is known about the relationship between these factors and H. pylori ‐related diseases. Our previous study revealed that human leukocyte antigen (HLA)‐DQB1*0401 plays an important role in the development of atrophic gastritis in H. pylori infected patients 7 . Other previous investigations have linked specific HLA class II alleles to cancer development 8–11 …”

Section: Introductionmentioning

confidence: 98%

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HLA‐DQB1 locus and gastric cancer in Helicobacter pylori infection

Watanabe

Aoyama

Sakai

et al. 2006

J of Gastro and Hepatol

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Background and Aims: It has been suggested that the incidence of digestive diseases associated with Helicobacter pylori is influenced by the strain diversity of H. pylori, factors involving the host or environment, and the duration of infection. The authors have previously reported that human leukocyte antigen (HLA)-DQB1*0401 plays an important role in the development of atrophic gastritis in H. pylori infected patients. The aim of the present study was to investigate the relationship between HLA-DQB1 genotype and cancer development. Methods: HLA-DQB1 genotyping was performed by the PCR-RFLP method on 122 H. pyloriinfected non-ulcer dyspepsia (NUD) patients, 53 gastric cancer patients and 28 uninfected controls. To reliably estimate the grade of atrophic gastritis, histological evaluation was performed. Results: The allele frequency of DQB1*0401 was significantly higher in intestinal type cancer patients compared with age-and sex-matched H. pylori-infected NUD patients. There was no significant difference in the mean atrophic scores of the biopsy samples from the lesser curvature of the mid-corpus between these groups. Conclusions: HLA-DQB1*0401 is a useful marker for determining susceptibility to intestinal type gastric cancer.

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Section: Discussionmentioning

confidence: 79%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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HLA‐DQB1 locus and gastric cancer in Helicobacter pylori infection

Watanabe

Aoyama

Sakai

et al. 2006

J of Gastro and Hepatol

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“…Some HLA class II alleles, such as HLA-DQA1*0102, *0301, and DQB1*0301 and *0401, have been associated with some H. pylori-related diseases. [9][10][11][12][13][14][15][16][17] A lower frequency of the DQA1*0102 allele has been associated Background. The goal of this study was to determine the importance of Helicobacter pylori CagAϩ, VacAϩ, and HLA-DQA1 alleles in a Mexican population with gastric cancer (GC).…”

Section: Introductionmentioning

confidence: 99%

Association of gastric cancer, HLA-DQA1, and infection with Helicobacter pylori CagA+ and VacA+ in a Mexican population

et al. 2004

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“…Scarce studies have been carried out concerning HLA in H. pylori ‐associated gastroduodenal diseases; among them, the DQA1*01:02 allele was found connected with a reduced risk for atrophic gastritis in a Japanese population, and the DQB1*06:02 allele was related to protection against peptic ulcer disease . In contrast, in another Asian population, the DQB1*04:01 allele was found as risk for atrophic gastritis and duodenal ulcer, DPB1*09:01 and DPA1*02:01 for gastric ulcer, and DRB1*04:05 for duodenal ulcer, whereas to our knowledge only one study has been carried out in Caucasian populations, where DQB1*03:01 was reported linked with GC . Thus, there is a need for extended studies in different populations and in larger patient groups, particularly in regions of Latin America and Asia where burden of GC is more severe.…”

mentioning

confidence: 99%

Polymorphisms in HLA‐DQ genes, together with age, sex, and Helicobacter pylori infection, as potential biomarkers for the early diagnosis of gastric cancer

et al. 2016

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Background: Polymorphisms in inflammation-related genes are factors associated with the development of gastroduodenal diseases in Helicobacter pylori-infected individuals. Materials and Methods: We aimed to analyze polymorphisms in HLA-DQ, together with other host and H. pylori variables as risk factors for precancerous and cancerous gastric lesions. 1052 individuals were studied, including nonatrophic gastritis (NAG), intestinal metaplasia (IM), gastric cancer (GC) or duodenal ulcer (DU) patients, and healthy volunteers. Results: Patients with alleles DQA*01:01 (OR 0.78), *01:02 (OR 0.29), *01:03 (OR 0.31), and DQB*02:01/02 (OR 0.40) showed a reduced risk for GC. A multivariate logistic regression analyses showed that patients with homozygote genotypes DQA1*03:01 (OR 7.27) and DQA1*04:01 (OR 8.99) and DQB1*05:01:01 (OR 12.04) were at significantly increased risk for GC. Multivariate analyses also demonstrated that age (OR>10.0) and gender (OR>2.0) were variables that influenced significantly the risk for GC, while H. pylori infection (OR>2.5) increased the risk for IM. Conclusions:We identified HLA-DQ alleles associated with IM and GC, and confirm that age, sex, and H. pylori infection are variables that also influence the risk for disease. The use of multiple markers, HLA-DQ alleles, age, sex, and H. pylori infection may be useful biomarkers for the early diagnosis of patients with IM and GC. K E Y W O R D Satrophic gastritis, gastric cancer, genetic polymorphism, H. pylori, HLA

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HLA DQB1*0401 is associated with the development of atrophic gastritis in H. pylori-infected patients

Cited by 7 publications

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HLA‐DQB1 locus and gastric cancer in Helicobacter pylori infection

HLA‐DQB1 locus and gastric cancer in Helicobacter pylori infection

Association of gastric cancer, HLA-DQA1, and infection with Helicobacter pylori CagA+ and VacA+ in a Mexican population

Polymorphisms in HLA‐DQ genes, together with age, sex, and Helicobacter pylori infection, as potential biomarkers for the early diagnosis of gastric cancer

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