Polymorphisms in <i>HLA‐DQ</i> genes, together with age, sex, and <i>Helicobacter pylori</i> infection, as potential biomarkers for the early diagnosis of gastric cancer

Pérez-Rodríguez, Martha; Partida-Rodríguez, Oswaldo; Camorlinga‐Ponce, Margarita; Flores-Luna, Lourdes; Lazcano, Eduardo; Gómez, Alejandro; Herrera‐Goepfert, Roberto; Medrano-Guzmán, Rafael; Torres, Javier

doi:10.1111/hel.12326

Cited by 23 publications

(30 citation statements)

References 47 publications

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“…For example in a meta-analysis about the role of MHC class II in pulmonary tuberculosis, DQA1*01:01 was associated with high susceptibility whereas DQA1*04:01 and DQA1*05:01 demonstrated protection against pulmonary tuberculosis [ 37 ]. The results of other studies also support this observation [ 38 , 39 , 40 , 41 ]. There is no specific pocket variant that is common in DQA1*03, *04 and *05 compared to DQA1*01.…”

Section: Discussionsupporting

confidence: 76%

Amino acid signatures in the HLA class II peptide-binding region associated with protection/susceptibility to the severe West Nile Virus disease

et al. 2018

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The MHC class II region in humans is highly polymorphic. Each MHC molecule is formed by an α and a β chain, produced by different genes, creating an antigen-binding groove. In the groove there are several pockets into which antigens anchor and fit. The affinity of this fitting determines the recognition specificity of a given peptide. Here, based on our previous results about the association of MHC class II with the WNV disease, we examined the role of the binding pockets of HLA-DPA1, -DQA1 and–DRB1 in the severe form of the disease. In HLA-DQA1, variants in all pockets 1, 6 and 9 were found to be associated with either protection and/or susceptibility to neuroinvasion caused by WNV. Similarly, pockets 7, 9 and 10 in HLA-DRB1 were associated with severe disease. Protein modeling of these molecules revealed structural and functional differences among alleles with opposite roles concerning the development of the disease. Different amino acids in positions α52 and α66 (HLA-DQA1) significantly influenced the peptide binding while DYWLR/EFA combination (HLA-DRB1) was associated with neuronal damage. Further studies could help us understand the selectivity of pocket variants in order to create suitable peptides for an effective response.

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Section: Discussionsupporting

confidence: 76%

Amino acid signatures in the HLA class II peptide-binding region associated with protection/susceptibility to the severe West Nile Virus disease

et al. 2018

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“…The decreasing trends of ASIR and ASMR were more pronounced in females. The control and prevention strategies for gastric cancer in males need to be strengthened 18,19 …”

Section: Discussionmentioning

confidence: 99%

Chinese and global burdens of gastric cancer from 1990 to 2019

Wang

Luan

et al. 2021

Cancer Medicine

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BackgroundGastric cancer is a common cancer in China. This project investigated the disease burden of gastric cancer from 1990 to 2019 in China and globally.MethodsThe global age‐standardized rates (ASRs) were extracted from the Global Burden of Disease. Moreover, the estimated annual percentage changes (eAPCs) in the ASRs of incidence (ASIR), mortality (ASMR), and disability‐adjusted life‐years (DALYs) were calculated to determine the trends by countries and regions.ResultsIn China, the ASIR declined from 37.56 to 30.64 per 100,000 and the ASMR declined from 37.73 to 21.72 per 100,000. The global ASIR decreased from 22.44 to 15.59 and the ASMR declined from 20.48 to 11.88 per 100,000 persons from 1990 to 2019. The ASIR was the lowest in Malawi (3.28 per 100,000) and the highest in Mongolia (43.7 per 100,000), whereas the ASMR was the lowest in the United States of America (3.40 per 100,000) and the highest in Mongolia (40.04 per 100,000) in 2019. The incidence of early‐onset gastric cancer increased in China. The DALYs attributed to gastric cancer presented a slight decrease during the period. China had a higher mortality/incidence ratio (0.845) and 5‐year prevalence (27.6/100,000) than most developed countries.ConclusionChina presented a steady decline in the incidence and mortality rates for gastric cancer. The global ASIR, ASMR, and DALYs showed a slight rise decrease. Different patterns of gastric cancer rates and temporal trends have been identified in different geographical regions, indicating that specific strategies are needed to prevent the increase in some countries.

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“…The population under study was selected as previously described [8], and similar procedures were followed for sample collection. Briefly, the population was selected from patients over 30 years of age seeking attention because of gastroduodenal symptoms at the Hospital de Oncología, Centro Médico Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), and Instituto Nacional de Cancerología, Secretaría de Salud, Mexico City.…”

Section: Methodsmentioning

confidence: 99%

Polymorphisms in IL-10 and TGF-β gene promoter are associated with lower risk to gastric cancer in a Mexican population

et al. 2019

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Background Helicobacter pylori infection is recognized as the main risk factor for gastric cancer (GC), the fifth most common neoplasia worldwide. H. pylori interacts with the immune system, disrupting the cytokine network and inducing chronic inflammation. This work aimed to evaluate the association between single nucleotide polymorphisms (SNPs) in selected cytokine gene promoters and GC. Methods The study included 359 subjects, 125 GC patients, 109 intestinal metaplasia (IM) patients and 125 asymptomatic controls. DNA was extracted from white blood cells and nine SNPs in cytokine gene promoters were genotyped using predesigned 5′-endonulease assays. The association of the SNPs with IM and GC was evaluated using multinomial regression models. Results Both genotypes, TC ( OR = 0.51, 95% CI = 0.27–0.98) and TT ( OR = 0.42, 95% CI = 0.20–0.91) in the locus − 509 of the TGF-β promoter were significantly associated with GC. The TT genotype in the locus − 819 of the IL-10 promoter was also significantly associated with GC ( OR = 0.37, 95% CI = 0.17–0.81). No significant association was found with SNPs IL-4 –590 T/C (rs1800629), IL-6 –573G/C (rs1800796), IL-10 –592C/A (rs1800872), IL-10 –1082A/G (rs1800896), and, IFN-γ –1615C/T (rs2069705). Conclusions SNPs in TGFβ (− 509 C/T, rs1800469) and IL-10 (− 819 C/T, rs1800871) promoters were associated with a lower risk for GC in a Mexican population.

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Polymorphisms in HLA‐DQ genes, together with age, sex, and Helicobacter pylori infection, as potential biomarkers for the early diagnosis of gastric cancer

Cited by 23 publications

References 47 publications

Amino acid signatures in the HLA class II peptide-binding region associated with protection/susceptibility to the severe West Nile Virus disease

Amino acid signatures in the HLA class II peptide-binding region associated with protection/susceptibility to the severe West Nile Virus disease

Chinese and global burdens of gastric cancer from 1990 to 2019

Polymorphisms in IL-10 and TGF-β gene promoter are associated with lower risk to gastric cancer in a Mexican population

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