HLA-DQB1 alleles in Italian patients with mucous membrane pemphigoid predominantly affecting the oral cavity.

Carrozzo, Marco; Fasano, M.B.; Broccoletti, Roberto; Carbone, M; Cozzani, Emanuele; Rendine, S.; Roggero, S.; Parodi, Aurora; Gandolfo, S

doi:10.1046/j.1365-2133.2001.04448.x

Cited by 51 publications

(18 citation statements)

References 14 publications

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“…Penfigóide cicatricial ocular (PCO), variante do pênfigo membrano-mucoso (PMM) (32) , é uma doença auto-imune que forma bolhas e cicatrizes em conjuntiva, podendo causar perda da visão quando inadequadamente tratada (13) . Em caucasianos, os haplótipos HLA-DR4-DQw7 e -DR5-DQw7 (13) , especialmente o alelo HLA-DQB1*0301 (13,(33)(34)(35)(36) , são tidos como marcadores genéticos para essa doença.…”

Section: Penfigóide Cicatricial Ocularunclassified

Associação do sistema de histocompatibilidade humano com doenças oftalmológicas

Alves¹,

Meyer²,

Toralles³

et al. 2006

Arq. Bras. Oftalmol.

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Section: Penfigóide Cicatricial Ocularunclassified

Associação do sistema de histocompatibilidade humano com doenças oftalmológicas

Alves¹,

Meyer²,

Toralles³

et al. 2006

Arq. Bras. Oftalmol.

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“…18 Both BP and MMP have been shown to have a strong linkage to DQB1*0301. 18,19 It has been demonstrated that the same patient may have antibodies against more than one autoantigen within the skin and mucous membrane, resulting in more than one autoimmune mucocutaneous disease. For example, patients with PF may develop BP, 20,21 patients with MMP may have PV (22), and some patients are affected with both PV and OCP.…”

Section: Introductionmentioning

confidence: 99%

Bioinformatics-Based Predictions of Peptide Binding to Disease-Associated HLA Proteins Suggest Explanation for Shared Autoimmunity

Glutting

Reche

Fridkis-Hareli³

2011

Immunol Immunogenet Insights

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Abstract:Aim: This study was designed to examine the immunogenetic basis for shared autoimmunity, resulting in autoantigen presentation that leads to the production of two or more disease-specific autoantibodies. Methods: A bioinformatics approach based on peptide binding predictions to disease-associated HLA determinants has been developed and tested here using 11 disease associations between autoimmune systemic and mucocutaneous blistering disorders. Various HLAs associated with antigens within a given "disease model" (set of HLA class II and protein sequences known to be associated with a specific autoimmune disease) were tested and ranked against the antigenic proteins, first with proteins they are known to associate with and then with proteins known to be implicated in a second disease model. In every case binding predictions were compared for different proteins binding to the same HLA. Subsequently, disease-related autoantigens have been tested for their binding affinity against each disease-specific HLA class II protein.Results: For a single HLA haplotype, several binders have been generated from a related autoantigen with the variable binding score. In most cases, the binding score corresponding to the interactions between the autoantigen-derived epitope and the HLA associated with one disease was similar or lower than the interactions between the epitope from proteins associated with the second disease and the same HLA. Notably, there was no compelling promiscuity in peptide binding to each of the HLA molecules, in spite of the promiscuous nature of HLA class II binding. Conclusions:The data suggest that, in susceptible individuals, shared autoimmunity might be initiated by two types of HLA/peptide interaction; first between an autoantigen-derived epitope and its disease-associated HLA molecules, and second, between a different peptide of the same autoantigen and HLA proteins specific for the second disease.

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“…HLA-DQB1*0301 allele, associated with MMP [111][112][113][114], was reported in patients with esophageal squamous cell carcinoma [113], gastric cancer [115], HPV-associated cervical neoplasia [116]. It was hypothesized, that the gene may have a role in T-cell recognition of basement membrane antigens resulting in production of IgG autoantibodies binding basement membrane antigens [117].…”

Section: Genetic Predispositionmentioning

confidence: 99%

Malignancy in Relation to Autoimmune Blistering Dermatoses: Molecular and Clinical Aspects

Pietkiewicz¹,

Gornowicz‐Porowska²,

Dmochowska³

et al. 2013

Highlights in Skin Cancer

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HLA-DQB1 alleles in Italian patients with mucous membrane pemphigoid predominantly affecting the oral cavity.

Abstract: Our data suggest that Italian patients with MMP lesions predominantly affecting the oral cavity present the same genetic predisposition linked to HLA-DQB1*0301 previously reported mainly in patients with OCP.

Cited by 51 publications

References 14 publications

Associação do sistema de histocompatibilidade humano com doenças oftalmológicas

Associação do sistema de histocompatibilidade humano com doenças oftalmológicas

Bioinformatics-Based Predictions of Peptide Binding to Disease-Associated HLA Proteins Suggest Explanation for Shared Autoimmunity

Malignancy in Relation to Autoimmune Blistering Dermatoses: Molecular and Clinical Aspects

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