HLA-DR association with the genetic susceptibility to develop ashy dermatosis in Mexican Mestizo patients

“…For instance, S. epidermidis has recently been shown to upregulate the expression of antimicrobial peptides in keratinocytes (Wanke et al, 2010). Immunogenetic components of the skin, such as the human leukocyte antigen (HLA) gene cluster, are shown to have associations with certain skin diseases, such as psoriasis (Bowcock and Woodson, 2004) and ashy dermatosis (Correa et al, 2007). It remains to be shown whether such associations are mediated by the microbial communities of the skin (Figure 1).…”

Section: Driving Forces Of Human Skin Microbiota Diversitymentioning

confidence: 99%

Skin microbiota: Microbial community structure and its potential association with health and disease

Rosenthal

Goldberg

Aiello

et al. 2011

Infection, Genetics and Evolution

196

173

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Skin, the largest human organ, is a complex and dynamic ecosystem inhabited by a multitude of microorganisms. Host demographics and genetics, human behavior, local and regional environmental characteristics, and transmission events may all potentially drive human skin microbiota variability, resulting in an alteration of microbial community structure. This alteration may have important consequences regarding health and disease outcomes among individuals. More specifically, certain diversity patterns of human microbiota may be predictive or diagnostic of disease. The purpose of this review is to briefly describe the skin microbiota, outline the potential determining factors driving its variability, posit the likelihood of an association between the resulting microbial community structure on the skin with disease outcomes among individuals, and finally, to present some challenges and implications for studying the skin microbiota.

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“…These brown-grey macules sometimes show erythematous borders [4,5]. Although the etiology of EDP is unclear there are some probable genetic factors related by genes located in the major histocompatibility complex region [6]. There are also some predisposing triggers that have been proposed, such as drugs (antibiotics, benzodiazepines, pesticides), endocrinopathies or HIV and hepatitis like infectious conditions [7][8][9].…”

Section: Discussionmentioning

confidence: 99%

Erythema Dyschromicum Perstans: A Case Report

Durmaz¹,

Özer²,

Fındık³

et al. 2017

J Pigment Disord

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Erythema dyscromicum perstans (EDP) or Ashy dermatosis is an uncommon pigmentary disorders which characterized with asymptomatic gray symmetric confluent macules over the body. It usually starts between first to three decades of the life and has a slow onset. This ailment can affect the palms, soles, scalp, nails and mucous membranes. Despite the definition of some etiological factors, the exact etiology of EDP is not clear. In this paper, we present a 24 years old patient with EDP.

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HLA-DR association with the genetic susceptibility to develop ashy dermatosis in Mexican Mestizo patients

Cited by 35 publications

References 18 publications

Ashy dermatosis: A comprehensive review

Ashy dermatosis: A comprehensive review

Skin microbiota: Microbial community structure and its potential association with health and disease

Erythema Dyschromicum Perstans: A Case Report

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