HLA-DR expression on monocytes and systemic inflammation in patients with ruptured abdominal aortic aneurysms

Haveman, Jan Willem; Berg, Aad P. van den; Verhoeven, Eric L.G.; Nijsten, Maarten W. N.; Dungen, J.J.A.M. van den; Zwaveling, JH

doi:10.1186/cc5017

Cited by 28 publications

(16 citation statements)

References 44 publications

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“…The level of HLA-DR then gradually returns to baseline level. This contrasts with a prolonged period of decreased HLA-DR expression observed in sepsis/severe trauma [36][37][38]. A possible explanation for this difference is the relatively brief exposure to endotoxin which occurs in our study compared with the prolonged presence of endotoxin in sepsis.…”

Section: Discussioncontrasting

confidence: 83%

Changes in HLA-DR expression, cytokine production and coagulation following endotoxin infusion in healthy human volunteers

Mant

Borozdenkova

Bradford

et al. 2008

International Immunopharmacology

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Section: Discussioncontrasting

confidence: 83%

Changes in HLA-DR expression, cytokine production and coagulation following endotoxin infusion in healthy human volunteers

Mant

Borozdenkova

Bradford

et al. 2008

International Immunopharmacology

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“…In adults, mHLA-DR expression on postoperative days 1–5 was significantly different between patients who later developed sepsis vs. with an uncomplicated course and was a factor with a high discriminatory power to identify patients with infection post cardiac surgery [ 16 ]. In patients with ruptured abdominal aortic aneurysms, mHLA-DR expression after surgery was significantly associated with mortality although this was not related to increased postoperative infection rates [ 73 ].…”

Section: Monocytic Hla-dr Expression In Specific Diseasesmentioning

confidence: 99%

Assessment of immune organ dysfunction in critical illness: utility of innate immune response markers

Pfortmueller

Meisel

Fux

et al. 2017

ICMx

128

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In critically ill patients, organ dysfunctions are routinely assessed, monitored, and treated. Mounting data show that substantial critical illness-induced changes in the immune system can be observed in most ICU patients and that not only “hyper-inflammation” but also persistence of an anti-inflammatory phenotype (as in sepsis-associated immunosuppression) is associated with increased morbidity and mortality. Despite common perception, changes in functional immunity cannot be adequately assessed by routine inflammatory biomarkers such as C-reactive protein, procalcitonin, or numerical analysis of leukocyte (sub)-counts. Cytokines appear also not suited due to their short half-life and pleiotropy, their unexclusive origin from immune cells, and their potential to undergo antagonization by circulating inactivating molecules. Thus, beyond leukocyte quantification and use of routine biomarkers, direct assessment of immune cell function seems required to characterize the immune systems’ status. This may include determination of, e.g., ex vivo cellular cytokine release, phagocytosis activity, and/or antigen-presenting capacity. In this regard, standardized flow-cytometric assessment of the major histocompatibility-II complex human leukocyte antigen (-D related) (HLA-DR) has gained particular interest. Monocytic HLA-DR (mHLA-DR) controls the interplay between innate and adaptive immunity and may serve as a “global” biomarker of injury-associated immunosuppression, and its decreased expression is associated with adverse clinical outcomes (e.g., secondary infection risk, mortality). Importantly, recent data demonstrate that injury-associated immunosuppression can be reversed—opening up new therapeutic avenues in affected patients. Here we discuss the potential scientific and clinical value of assessment of functional immunity with a focus on monocytes/macrophages and review the current state of knowledge and potential perspectives for affected critically ill patients.

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“…Haveman et al 28 in 2006 evaluated systemic inflammatory cytokine concentrations in 30 healthy controls and 26 patients with ruptured abdominal aortic aneurysms (AAA) who underwent open repair and survived the surgery. Blood samples were collected for up to 2 weeks.…”

Section: Surgerymentioning

confidence: 99%

Interleukin-6 in Surgery, Trauma, and Critical Care Part II: Clinical Implications

Jawa

Anillo

Huntoon

et al. 2010

J Intensive Care Med

184

112

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A variety of cytokines play a role in the inflammatory response. Interleukin-6 (IL-6)-type cytokines are released in response to tissue injury or an inflammatory stimulus, and act locally and systemically to generate a variety of physiologic responses. Interleukin-6 concentrations are elevated after surgery, trauma, and critical illness. The magnitude of IL-6 elevation correlates with the extent of tissue trauma/injury severity. Furthermore, there is an association between IL-6 elevation and adverse outcome. Interleukin-6 levels can also be used to stratify patients for therapeutic intervention.

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HLA-DR expression on monocytes and systemic inflammation in patients with ruptured abdominal aortic aneurysms

Cited by 28 publications

References 44 publications

Changes in HLA-DR expression, cytokine production and coagulation following endotoxin infusion in healthy human volunteers

Changes in HLA-DR expression, cytokine production and coagulation following endotoxin infusion in healthy human volunteers

Assessment of immune organ dysfunction in critical illness: utility of innate immune response markers

Interleukin-6 in Surgery, Trauma, and Critical Care Part II: Clinical Implications

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