HLA-DRB1*01 allele and low plasma immunoglobulin G1 concentration may predispose to herpes-associated recurrent lymphocytic meningitis

Kallio-Laine, Katariina; Seppänen, Mikko; Aittoniemi, Janne; Kautiainen, Hannu; Seppälä, Ilkka; Valtonen, Ville; Färkkilä, Markus; Kalso, Eija; Lokki, Marja-Liisa

doi:10.1016/j.humimm.2009.10.014

Cited by 15 publications

(15 citation statements)

References 24 publications

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“…Previous studies have correlated HLA type or SNPs in the HLA region with the presence or severity of HSV infection (10-15). Resistance to initial infection and control of established HSV infection likely involve different genetic loci.…”

Section: Discussionmentioning

confidence: 99%

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HLA Class I and II alleles, heterozygosity and HLA-KIR interactions are associated with rates of genital HSV shedding and lesions

et al. 2016

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Variation at HLA and KIR loci is associated with the severity of viral infections. To assess associations of genital HSV-2 infection with human HLA and KIR genetic loci, we measured the frequencies of genital HSV DNA detection and of genital lesions in HSV-2 seropositive persons. We followed 267 HSV-2 seropositive persons who collected daily genital swabs and recorded lesions for ≥30 days. All persons were laboratory- documented as HIV-seronegative, and all were Caucasian by self-report. HSV detection rate and lesion frequency were compared by genotype using Poisson regression. Overall, HSV was detected on 19.1% of days and lesions on 11.6% of days. The presence of HLA-A*01 was directly associated with HSV detection frequency while the presence of HLA-C*12 was inversely associated with HSV detection frequency. The presence of HLA-A*01 was directly associated with lesion rate, while HLA-A*26, -C*01 and -DQB1*0106 were associated with decreased lesions. We observed an interaction between the absence of both 2DS4del and HLA-Bw4 and higher lesion rate. Heterozygosity of HLA was also associated with reduced lesion frequency. Immune control of genital HSV infection relies on multiple interacting immunogenetic elements, including epistatic interactions between HLA and KIR.

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Section: Discussionmentioning

confidence: 99%

“…Several complement protein genes are also located in the HLA major histocompatibility complex (MHC) region. Homozygous null alleles for C4A or the isotype gene C4B has been reported in severe herpes labialis due to HSV-1 (15). …”

Section: Discussionmentioning

confidence: 99%

HLA Class I and II alleles, heterozygosity and HLA-KIR interactions are associated with rates of genital HSV shedding and lesions

et al. 2016

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“…RBLM is estimated to occur after primary HSV-2 meningitis in 20%-30% of cases (3). Previous research has reported an association of low serum IgG subclass 1 (IgG1) and IgG subclass 3 (IgG3) levels with increased frequency of RBLM (2). We report an unusual case of serum IgG subclass 2 immunodeficiency in a patient with 8 lifetime episodes of RBLM.…”

mentioning

confidence: 77%

“…In a study of 21 patients with RBLM, Kallio-Laine et al (2) showed that low serum IgG1 levels were associated with increased frequency of recurrent meningitis episodes. They also reported a trend toward lower serum IgG3 in RBLM patients.…”

Section: Discussionmentioning

confidence: 99%

“…The most common cause is herpes simplex virus-2 (HSV-2), a member of the family Herpesviridae. According to older case series, HSV has accounted for an estimated 0.5%-18% of viral meningitis cases (2). A study conducted by Kallio-Laine et al (1) in Finland among 665 patients treated for lymphocytic meningitis indicated a prevalence of HSV-2-associated meningitis of 2.2 cases/100,000 population.…”

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confidence: 99%

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Recurrent Herpes Simplex Virus 2 Lymphocytic Meningitis in Patient with IgG Subclass 2 Deficiency

Goyal¹,

Ali²

2020

Emerg. Infect. Dis.

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Refractory atypical trigeminal neuralgia associated with reactivated herpesvirus infection: pathogenetic link and efficacy of combination antiviral therapy

Maltsev

Fedirko²

2022

VirusDis.

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HLA-DRB1*01 allele and low plasma immunoglobulin G1 concentration may predispose to herpes-associated recurrent lymphocytic meningitis

Cited by 15 publications

References 24 publications

HLA Class I and II alleles, heterozygosity and HLA-KIR interactions are associated with rates of genital HSV shedding and lesions

HLA Class I and II alleles, heterozygosity and HLA-KIR interactions are associated with rates of genital HSV shedding and lesions

Recurrent Herpes Simplex Virus 2 Lymphocytic Meningitis in Patient with IgG Subclass 2 Deficiency

Refractory atypical trigeminal neuralgia associated with reactivated herpesvirus infection: pathogenetic link and efficacy of combination antiviral therapy

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