HLA-G inhibits the transendothelial migration of human NK cells

Interactions Between Natural Killer Cells, Cortisol and Prolactin in Malaria During Pregnancy

“…59,60 Since NK cells have receptors for nonclassical class I molecules, some have hypothesized that HLA-G protects fetal cells from lysis by maternal NK cells through this mechanism. Using a migration assay, NK cell trafficking through the HLA-G-expressing endothelial cells was reduced.…”

A Specific Interferon (IFN)-stimulated Response Element of the Distal HLA-G Promoter Binds IFN-regulatory Factor 1 and Mediates Enhancement of This Nonclassical Class I Gene by IFN-β

“…Complementary DNAs were prepared from total RNA using oligo(dT) [12][13][14][15][16][17][18] primers and Moloney murine leukemia virus reverse transcriptase (Life Technologies, Inc.). PCR amplification of the cDNA preparation was carried out in a thermal cycler (PerkinElmer Life Sciences, Norwalk, CT).…”

“…HLA-G associates with a wide array of nonamer peptides (7) and binds to the CD8 T-cell coreceptor (8,9). Other immunomodulatory roles, such as its capacity to elicit a T-cell receptor-restricted response in transgenic mice (10), to trigger apoptosis of activated T and NK cells bearing the CD8 molecule (11), to impair NK cell migration (12), and to modulate cytokine (13,14) or the function of B or myelomonocytic cells bearing killing inhibitory receptors, have also been evoked. Tissue-specific patterns of HLA-G expression and their frequent alteration in pathological situations such as pregnancy disorders (15), viral infections (16 -19), tumors (20 -24), or transplantation (25) may modulate the mounting of an efficient immune response and thus provide an additional mechanism to escape immune surveillance.…”

Association between two polymorphisms in the HLA-G gene and angiographic coronary artery disease

“…Of interest, an association between HLA-G polymorphisms and other chronic inflammatory disorders, such as inflammatory bowel disease (33,34), asthma (35,36) and multiple sclerosis (37)(38)(39), has been repeatedly reported. Besides the potential role played by HLA-G in inflammation and immunity (15), there is evidence to suggest that this molecule may also modulate endothelial cell activity (40,41). In this regard, it has been previously demonstrated that purified recombinant soluble HLA-G is capable of downregulating endothelial cell proliferation and migration in vitro (42).…”