HLA Haplotypes in Singapore: A Study of Mothers and Their Cord Blood Units

Tang, Ting; Hou, Lihua; Chen, Minghua; Belle, Ian; Mack, Steven J.; Lancaster, Alex K.; Ho, Grace Y.; Hwang, William Ying Khee; Alsagoff, Fidah; Ng, Jennifer; Hurley, Carolyn Katovich

doi:10.1016/j.humimm.2007.01.005

Cited by 13 publications

(6 citation statements)

References 26 publications

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“…Regarding HLA‐A, ‐B, ‐DR haplotypes, A33‐B58‐DR17, A2‐B46‐DR9, A33‐B44‐DR7, and A11‐B75‐DR12 were commonly found similar to previous studies among Thais (14, 17). As the population of central Thailand is a mixture of original Thai and Southern Chinese, three common haplotypes, A33‐B58‐DR17, A2‐B46‐DR9, and A11‐B75‐DR12, were found similar to Chinese, Taiwanese, and Singaporean populations (18–20). Comparing HLA HFs, observed more than 2% in the TSCDR with Chinese bone marrow donors, the HLA‐A33‐B44‐DR7 HF (2.85%) was higher than that of Chinese bone marrow donors (0.41%), whereas the common HLA‐A30‐B13‐DR7 HF (4.52%) in Chinese bone marrow donors was higher than TSCDR (1.56%) (18).…”

Section: Antigen Frequencies Of Hla‐a ‐B and ‐Dr In The Thai Stem Csupporting

confidence: 84%

HLA-A, -B, -DR haplotype frequencies in the Thai Stem Cell Donor Registry

et al. 2010

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This study aimed to report antigen and haplotype frequencies (HFs) in the Thai Stem Cell Donor Registry (TSCDR). From 16,807 human leukocyte antigen (HLA)-A, -B, and -DR typed donors, 19 HLA-A, 41 HLA-B, and 13 HLA-DR antigens were found. HLA-A43, A80, B78, B82, B83, and DR18 were not observed. A total of 1921 haplotypes were estimated and 245 haplotypes were reliable and their cumulative HF was 75.74%. Similar to previous Thai subpopulation studies, the most common haplotypes were HLA-A33-B58-DR17 (4.54%), A2-B46-DR9 (4.11%), A33-B44-DR7 (2.85%), and A11-B75-DR12 (2.00%). To evaluate the probability in finding matched donors, from April 2002 to August 2008, 793 Thai patients were requested for unrelated stem cell donor searching. The number of patients with HLA-A, -B, -DR split matched donor found were 49%. Only 8% of the patients found matched donor within 1 month. However, high-resolution HLA-A, -B, -DR typing in TSCDR is suggested to accurately estimate HFs and evaluate the probability in finding a matched donor for patients in the future.

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Section: Antigen Frequencies Of Hla‐a ‐B and ‐Dr In The Thai Stem Csupporting

confidence: 84%

HLA-A, -B, -DR haplotype frequencies in the Thai Stem Cell Donor Registry

et al. 2010

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“…Thirty-two of the 34 haplotypes (94%) determined in Singapore Chinese CB units that occurred more than once in the study were observed in our current investigation (Supplementary Table 1). Conversely, 13 of the 21 haplotypes (62%) observed more than 10 times in our study (Table 3) were found in the haplotypes occurring more than once in Singapore Chinese CB units [15]. Although Asian Americans are represented heterogeneously by many ethnic groups in the United States [10,19], 15 of the 20 most common haplotypes determined in Asian Americans [19] were found in this study ( Table 4).…”

Section: Hla Haplotype Frequencies and Ldmentioning

confidence: 44%

“…We compared our predicted haplotypes with the results of the haplotype study on Singapore Chinese CB units [15] and other population studies [10,[13][14][15][16]. Thirty-two of the 34 haplotypes (94%) determined in Singapore Chinese CB units that occurred more than once in the study were observed in our current investigation (Supplementary Table 1).…”

Section: Hla Haplotype Frequencies and Ldmentioning

confidence: 74%

Human leukocyte antigen-A, -B, and -DRB1 haplotypes of cord blood units in the Tzu Chi Taiwan Cord Blood Bank

2008

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“…The two studies’ results are in good agreement with each other. Concerning four‐locus haplotypes, one Singaporean study (Tang et al. , 2007) reported the most common A–Cw–B–DRB1 haplotypes from 536 Chinese Singapore Bone Marrow Program donors were A*02–Cw*01–B*46–DRB1*09 (HF= 5.59%), A*33–Cw*03–B*58–DRB1*03 (HF = 5.11%) and A*11–Cw*08–B*15–DRB1*12 (HF = 4.04%); and the most common A–Cw–B–DRB1 haplotypes from 258 Chinese Singapore Cord Blood Bank registry data were A*3303g–Cw*0302g–B*5801–DRB1*0301 (HF = 3.88%), A*0201g–Cw*0102g–B*4601/2–DRB1*0901 (HF = 3.49%) and A*1101g–Cw*0801g–B*1502g–DRB1*1202 (HF = 3.49%).…”

Section: Discussionmentioning

confidence: 99%

Analysis of high‐resolution HLA‐A, ‐B, ‐Cw, ‐DRB1, and ‐DQB1 alleles and haplotypes in 718 Chinese marrow donors based on donor–recipient confirmatory typings

Hei

Deng

et al. 2009

Int J Immunogenetics

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High-resolution human leucocyte antigen (HLA)-A, -B, -Cw, -DRB1, and -DQB1 alleles and haplotype frequencies were analysed from 718 Chinese healthy donors selected from the Chinese Marrow Donor Program registry based on HLA donor-recipient confirmatory typings. A total of 28 HLA-A, 61 HLA-B, 30 HLA-Cw, 40 HLA-DRB1 and 18 HLA-DQB1 alleles were identified, and HLA-A*1101, A*2402, A*0201, B*4001, Cw*0702, Cw*0102, Cw*0304, DRB1*0901, DRB1*1501, DQB1*0301, DQB1*0303 and DQB1*0601 were found with frequencies higher than 10% in this study population. Multiple-locus haplotype analysis by the maximum-likelihood method revealed 45 A-B, 38 Cw-B, 47 B-DRB1, 29 DRB1-DQB1, 24 A-B-DRB1, 38 A-Cw-B, 23 A-Cw-B-DRB1, 33 Cw-B-DRB1-DQB1 and 22 A-Cw-B-DRB1-DQB1 haplotypes with frequencies >0.5%. The most common two-, three-, four- and five-locus haplotypes in this population were: A*0207-B*4601 (7.34%), Cw*0102-B*4601 (8.71%), B*1302-DRB1*0701 (6.19%), DRB1*0901-DQB1*0303 (14.27%), A*3001-B*1302-DRB1*0701 (5.36%), A*0207-Cw*0102-B*4601 (7.06%), A*3001-Cw*0602-B*1302-DRB1*0701 (5.36%), Cw*0602-B*1302-DRB1*0701-DQB1*0202 (6.12%) and A*3001-Cw*0602-B*1302-DRB1*0701-DQB1*0202 (5.29%). Presentation of the high-resolution alleles and haplotypes data at HLA-A, -B, -Cw, -DRB1 and -DQB1 loci will be useful for HLA matching in transplantation as well as for other medical and anthropological applications in the Chinese population.

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HLA Haplotypes in Singapore: A Study of Mothers and Their Cord Blood Units

Cited by 13 publications

References 26 publications

HLA-A, -B, -DR haplotype frequencies in the Thai Stem Cell Donor Registry

HLA-A, -B, -DR haplotype frequencies in the Thai Stem Cell Donor Registry

Human leukocyte antigen-A, -B, and -DRB1 haplotypes of cord blood units in the Tzu Chi Taiwan Cord Blood Bank

Analysis of high‐resolution HLA‐A, ‐B, ‐Cw, ‐DRB1, and ‐DQB1 alleles and haplotypes in 718 Chinese marrow donors based on donor–recipient confirmatory typings

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