HLA polymorphism in Bulgarians defined by high‐resolution typing methods in comparison with other populations

Ivanova, Milena; Rozemuller, Erik H.; Tyufekchiev, N.; Michailova, A.; Tilanus, M.G.J.; Naumova, E.

doi:10.1034/j.1399-0039.2002.600605.x

Cited by 41 publications

(44 citation statements)

References 16 publications

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“…2). Their frequencies represented more than 60% of those observed for the given locus and correspond to the most frequent alleles found in (Ivanova et al 2001;Ivanova et al 2002). Such allele distribution is characteristic for South European populations (Bodmer et al 1997;Terasaki et al 1997;Geer et al 1998).…”

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confidence: 94%

Bulgarian Bone Marrow Donors Registry—past and future directions

et al. 2007

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Recently Bulgarian Bone Marrow Donors Registry (BBMDR) has been established and since August 2005 it has been a member of Bone Marrow Donors Worldwide. Currently the number of healthy donors included in the BBMDR is relatively low. All donors included in the BBMDR are typed for HLA-A, -B, -DRB loci. Phylogenetic analysis based on HLA allele frequencies shows that Bulgarians were characterized with closest genetic similarity to Macedonians, Greeks, Romanians, Cretans and Sardinians in comparison to the other European and Mediterranean populations. On the contrary the second largest ethnic minority-the Roma were the closest to the other Roma populations and North Indians. These differences were due to the predominance of alleles and haplotypes that are specific for the Asian and the other Roma populations. These specific genetic profiles in the Bulgarian ethnic minorities justify the need of an adequate representation of minorities in BBMDR. Future directions for BBMDR development are discussed, including an increase of the total number of donors and these for ethnic minorities, as well the enhancement of the level of resolution of the HLA typing for the donors in the registry.

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confidence: 94%

Bulgarian Bone Marrow Donors Registry—past and future directions

et al. 2007

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“…Immunogenetic studies based on HLA allele and haplotype distribution showed significant heterogeneity of the Bulgarian population (Ivanova et al 2002). That could be explained by the ethnic Fig.…”

Section: Introductionmentioning

confidence: 99%

Cord blood stem cell transplantation. Why it is necessary to establish a Bulgarian cord blood bank?

et al. 2007

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The allogenic transplantation of hemopoietic stem cell from bone marrow and peripheral blood is limited due to the necessity to identify HLA matched donor within the family or in bone marrow donor registries. Although, more than 10 million donors are available worldwide, completely HLA matched donors could be found only for 75% of the patients. It is well known that transplantations of hematopoietic stem cell from cord blood are characterized with a lower risk of GvHD and therefore do not require so strict criteria for HLA matching, and less time for search of matched donor is needed. The necessity to establish a National cord blood bank in Bulgaria is emphasized further by the heterogeneity of HLA allele and haplotype distribution in the Bulgarian population. That could be explained by the ethnic diversity of the population. As a result some alleles are more frequent in Bulgarians compared to other populations. The organization, accreditation, and development of a strategy for a National cord blood bank will be discussed.

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“…Indeed, genetic distance and principal component analyses have demonstrated that the allele and haplotype distribution of class I and class II loci are racially and geographically restricted. This has prompted the use of HLA class I and class II haplotypes and genotypes in population genetic analyses and evolution studies [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%