HLA Polymorphism in Israel*: 1. Jews of Polish Extraction

Gazit, Ephraim; Brautbar, Chaim; Efter, T.; Cohen, Rachel E.; Yehoshua, H.; Zamir, R.

doi:10.1111/j.1399-0039.1978.tb01247.x

Cited by 6 publications

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“…Isolation, intermarriage, proselytism, and genetic drift contributed to the genetic variability presently observed in the Jewish ethnic groups. However, in spite of substantial external genetic effects, the Ashkenazi Jews were found, in many studies, to be genetically related to the other Jewish ethnic groups (37–41).…”

Section: Discussionmentioning

confidence: 99%

Common ancestral origin of pemphigus vulgaris in Jews and Spaniards: a study using microsatellite markers

Loewenthal

Slomov

et al. 2004

Tissue Antigens

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Pemphigus is a group of autoimmune blistering diseases of the skin and mucous membranes. The association of pemphigus with human leukocyte antigen (HLA) is widely accepted. It was described in many ethnic groups and in most countries of the world. Studies showed that the associated HLA haplotype in Jewish pemphigus vulgaris (PV) patients is HLA-B38, DRB1*0402, and DQB1*0302; or HLA-B35, DRB1*0402, and DQB1*0302. Similar associations with class II genes were found in Spanish non-Jewish PV patients. As Jews lived in Spain for hundreds of years and many converted to Christianity, the presence of the same HLA haplotype in the Jewish and Spanish PV suggests that they may share the same founder. Microsatellite markers which span the entire major histocompatibility complex (MHC) locus were used as genetic probes. They were utilized to dissect the MHC region in the search for possible common haplotypes, besides HLA, which may provide an answer to this question. It was found that in both cohorts, in addition to HLA class II genes, there are probably genes in the class I region which are associated with PV. Alleles belonging to the associated markers were used to construct haplotypes and to estimate genetic distances. The distance between the two PV cohorts is relatively short, but the distance between the Jewish patients and the Jewish controls is greater compared to the distance between Spanish patients and Spanish controls. In both PV populations, the same microsatellite haplotypes in addition to a common class II haplotype were found, suggesting that both patient populations originated from the same genetic stock and, therefore, share the same ancestral disease gene.

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Section: Discussionmentioning

confidence: 99%

Common ancestral origin of pemphigus vulgaris in Jews and Spaniards: a study using microsatellite markers

Loewenthal

Slomov

et al. 2004

Tissue Antigens

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The relationship between HLA antigens and Bermuda grass hayfever

et al. 1978

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Associations between atopic diseases and lymphocyte antigens seem to be possible, but not certain (for a review see McMichael and McDevitt 1977). Several studies (Levine et al. 1972, Marsh et al. 1973, Yoo et al. 1976, Bruce et al. 1976, Scholtz et al. 1976, Seignalet et al. 1976, Marsh and Bias 1977 have shown a certain association between atopy and different HLA antigens or haplotypes, within the same family, but without demonstrating a definite association with one specific antigen or haplotype. Rachelefsky and coworkers (1976) found a strong association between atopic asthma and B lymphocyte group 2, which was not paralleled by an association with the HLA complex. Since hayfever is the classical, representative atopic disease, we present here the HLA typing of 141 patients suffering from Bermuda grass hayfever. These patients comprise two groups: 86 of them were studied during the 1975 season; 65 during the 1976 season; and 10 during both seasons. The diagnosis of hayfever was based on a positive correlation between: (a) family history (several cases of proven atopy in three consecutive generations); (b) clinical picture (seasonal rhinitis, conjunctivitis, and asthma during the Bermuda grass blooming season only); and (c) positive skin tests to whole Bermuda grass extract, obtained from the Hollister-Stier Laboratory. The controls were pooled from data on a recently typed healthy Jewish population (Brautbar et al. 1977, Gazit et al. 1978a, b, c, Zamir et al. 1978) so as to match the stratification of the patients into individuals of Ashkenazi (Russia, Poland, and Roumania) and Sephardic (Marocco and Iraq) origin, in a total of 597 controls for 65 patients.For HLA typing the standard N.I.H. technique was employed (Brand et aL 1970) and the lymphocytes were typed for 9 and 16 antigens at locus A and B, respectively, with 120 alloantisera obtained from the N.I.H. serum bank and from local preparations. The results in both groups (1975 and 1976) show an association with allele B27, at a significance of 1%, and this suggests more than a spurious correlation.The data were subjected to a relative risk analysis. The Haldane (1955) relative risk evaluation uses the formula:

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HLA Polymorphism in Israel: 2. Israeli Jews originating from Russia

et al. 1978

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HLA typing of 123 Israel Jews of Russian origin showed a high frequency for HLA--A1, A2, Aw19 and B14, Bw16 and Bw35 of the A and B loci, respectively. The most frequently occuring haplotypes were (A1, B17), (Aw25, B18), (Aw26, Bw16), (Aw19, B13), (Aw23, B5) and (Aw25, Bw35). This study reveals a striking resemblance in the distribution of frequencies of HLA alleles and haplotypes between Russian Jews and two other East European Jewish communities (presented in this issue) of Polish and Rumanian origin.

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HLA Polymorphism in Israel*: 1. Jews of Polish Extraction

Cited by 6 publications

References 1 publication

Common ancestral origin of pemphigus vulgaris in Jews and Spaniards: a study using microsatellite markers

Common ancestral origin of pemphigus vulgaris in Jews and Spaniards: a study using microsatellite markers

The relationship between HLA antigens and Bermuda grass hayfever

HLA Polymorphism in Israel: 2. Israeli Jews originating from Russia

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